精神保健研究所 精神疾患病態研究部。私たちは「脳とこころの科学」の先駆的研究活動を展開しています。

研究成果

学術論文

2020年

  1. Shiino T, Miura K, Fujimoto M, Kudo N, Yamamori H, Yasuda Y,Ikeda M, Hashimoto R. Comparison of eye movements in schizophrenia and autism spectrum disorder. Neuropsychopharmacol Rep, 40(1):92-95, 2020.3 DOI:10.1002/npr2.12085
  2. Morita K, Miura K, Kasai K, Hashimoto R. Eye movement characteristics in schizophrenia: A recent update with clinical implications. Neuropsychopharmacol Rep, 40(1):2-9, 2020.3 DOI:10.1002/npr2.12087
  3. Sønderby IE, Gústafsson Ó, Doan NT, Hibar DP, Martin-Brevet S, Abdellaoui A, Ames D, Amunts K, Andersson M, Armstrong NJ, Bernard M, Blackburn N, Blangero J, Boomsma DI, Bralten J, Brattbak HR, Brodaty H, Brouwer RM, Bülow R, Calhoun V, Caspers S, Cavalleri G, Chen CH, Cichon S, Ciufolini S, Corvin A, Crespo-Facorro B, Curran JE, Dale AM, Dalvie S, Dazzan P, de Geus EJC, de Zubicaray GI, de Zwarte SMC, Delanty N, den Braber A, Desrivières S, Donohoe G, Draganski B, Ehrlich S, Espeseth T, Fisher SE, Franke B, Frouin V, Fukunaga M, Gareau T, Glahn DC, Grabe H, Groenewold NA, Haavik J, Håberg A, Hashimoto R, (151名中52番目) Hehir-Kwa JY, Heinz A, Hillegers MHJ, Hoffmann P, Holleran L, Hottenga JJ, Hulshoff HE, Ikeda M, Jahanshad N, Jernigan T, Jockwitz C, Johansson S, Jonsdottir GA, Jönsson EG, Kahn R, Kaufmann T, Kelly S, Kikuchi M, Knowles EEM, Kolskår KK, Kwok JB, Hellard SL, Leu C, Liu J, Lundervold AJ, Lundervold A, Martin NG, Mather K, Mathias SR, McCormack M, McMahon KL, McRae A, Milaneschi Y, Moreau C, Morris D, Mothersill D, Mühleisen TW, Murray R, Nordvik JE, Nyberg L, Olde Loohuis LM, Ophoff R, Paus T, Pausova Z, Penninx B, Peralta JM, Pike B, Prieto C, Pudas S, Quinlan E, Quintana DS, Reinbold CS, Marques TR, Reymond A, Richard G, Rodriguez-Herreros B,Roiz-Santiañez R, Rokicki J, Rucker J, Sachdev P, Sanders AM, Sando SB, Schmaal L, Schofield PR, Schork AJ, Schumann G, Shin J, Shumskaya E, Sisodiya S, Steen VM, Stein DJ, Steinberg S, Strike L, Teumer A, Thalamuthu A, Tordesillas-Gutierrez D, Turner J, Ueland T, Uhlmann A, Ulfarsson MO, van 't Ent D, van der Meer D, van Haren NEM, Vaskinn A, Vassos E, Walters GB, Wang Y, Wen W, Whelan CD, Wittfeld K, Wright M, Yamamori H, Zayats T, Agartz I, Westlye LT, Jacquemont S, Djurovic S, Stefánsson H, Stefánsson K, Thompson P, Andreassen OA; European Consortium, for the ENIGMA-CNV working group. Dose response of the 16p11.2 distal copy number variant on intracranial volume and basal ganglia. Mol Psychiatry. 25(3):584-602, 2020.3 DOI:10.1038/s41380-018-0118-1
  4. Grasby KL, Jahanshad N, Painter JN, Colodro-Conde L, Bralten J, Hibar DP, Lind PA, Pizzagalli F, Ching CRK, McMahon MAB, Shatokhina N, Zsembik LCP, Thomopoulos SI, Zhu AH, Strike LT, Agartz I, Alhusaini S, Almeida MAA, Alnæs D, Amlien IK, Andersson M, Ard T, Armstrong NJ, Ashley-Koch A, Atkins JR, Bernard M, Brouwer RM, Buimer EEL, Bülow R, Bürger C, Cannon DM, Chakravarty M, Chen Q, Cheung JW, Couvy-Duchesne B, Dale AM, Dalvie S, de Araujo TK, de Zubicaray GI, de Zwarte SMC, den Braber A, Doan NT, Dohm K, Ehrlich S, Engelbrecht HR, Erk S, Fan CC, Fedko IO, Foley SF, Ford JM, Fukunaga M, Garrett ME, Ge T, Giddaluru S, Goldman AL, Green MJ, Groenewold NA, Grotegerd D, Gurholt TP, Gutman BA, Hansell NK, Harris MA, Harrison MB, Haswell CC, Hauser M, Herms S, Heslenfeld DJ, Ho NF, Hoehn D, Hoffmann P, Holleran L, Hoogman M, Hottenga JJ, Ikeda M, Janowitz D, Jansen IE, Jia T, Jockwitz C, Kanai R, Karama S, Kasperaviciute D, Kaufmann T, Kelly S, Kikuchi M, Klein M, Knapp M, Knodt AR, Krämer B, Lam M, Lancaster TM, Lee PH, Lett TA, Lewis LB, Lopes-Cendes I, Luciano M, Macciardi F, Marquand AF, Mathias SR, Melzer TR, Milaneschi Y, Mirza-Schreiber N, Moreira JCV, Mühleisen TW, Müller-Myhsok B, Najt P, Nakahara S, Nho K, Olde Loohuis LM, Orfanos DP, Pearson JF, Pitcher TL, Pütz B, Quidé Y, Ragothaman A, Rashid FM, Reay WR, Redlich R, Reinbold CS, Repple J, Richard G, Riedel BC, Risacher SL, Rocha CS, Mota NR, Salminen L, Saremi A, Saykin AJ, Schlag F, Schmaal L, Schofield PR, Secolin R, Shapland CY, Shen L, Shin J, Shumskaya E, Sønderby IE, Sprooten E, Tansey KE, Teumer A, Thalamuthu A, Tordesillas-Gutiérrez D, Turner JA, Uhlmann A, Vallerga CL, van der Meer D, van Donkelaar MMJ, van Eijk L, van Erp TGM, van Haren NEM, van Rooij D, van Tol MJ, Veldink JH, Verhoef E, Walton E, Wang M, Wang Y, Wardlaw JM, Wen W, Westlye LT, Whelan CD, Witt SH, Wittfeld K, Wolf C, Wolfers T, Wu JQ, Yasuda CL, Zaremba D, Zhang Z, Zwiers MP, Artiges E, Assareh AA, Ayesa-Arriola R, Belger A, Brandt CL, Brown GG, Cichon S, Curran JE, Davies GE, Degenhardt F, Dennis MF, Dietsche B, Djurovic S, Doherty CP, Espiritu R, Garijo D, Gil Y, Gowland PA, Green RC, Häusler AN, Heindel W, Ho BC, Hoffmann WU, Holsboer F, Homuth G, Hosten N, Jack CR Jr, Jang M, Jansen A, Kimbrel NA, Kolskår K, Koops S, Krug A, Lim KO, Luykx JJ, Mathalon DH, Mather KA, Mattay VS, Matthews S, Mayoral Van Son J, McEwen SC, Melle I, Morris DW, Mueller BA, Nauck M, Nordvik JE, Nöthen MM, O'Leary DS, Opel N, Martinot MP, Pike GB, Preda A, Quinlan EB, Rasser PE, Ratnakar V, Reppermund S, Steen VM, Tooney PA, Torres FR, Veltman DJ, Voyvodic JT, Whelan R, White T, Yamamori H, Adams HHH, Bis JC, Debette S, Decarli C, Fornage M, Gudnason V, Hofer E, Ikram MA, Launer L, Longstreth WT, Lopez OL, Mazoyer B, Mosley TH, Roshchupkin GV, Satizabal CL, Schmidt R, Seshadri S, Yang Q; Alzheimer’s Disease Neuroimaging Initiative; CHARGE Consortium; EPIGEN Consortium; IMAGEN Consortium; SYS Consortium; Parkinson’s Progression Markers Initiative, Alvim MKM, Ames D, Anderson TJ, Andreassen OA, Arias-Vasquez A, Bastin ME, Baune BT, Beckham JC, Blangero J, Boomsma DI, Brodaty H, Brunner HG, Buckner RL, Buitelaar JK, Bustillo JR, Cahn W, Cairns MJ, Calhoun V, Carr VJ, Caseras X, Caspers S, Cavalleri GL, Cendes F, Corvin A, Crespo-Facorro B, Dalrymple-Alford JC, Dannlowski U, de Geus EJC, Deary IJ, Delanty N, Depondt C, Desrivières S, Donohoe G, Espeseth T, Fernández G, Fisher SE, Flor H, Forstner AJ, Francks C, Franke B, Glahn DC, Gollub RL, Grabe HJ, Gruber O, Håberg AK, Hariri AR, Hartman CA, Hashimoto R〈299番目360 名中), Heinz A, Henskens FA, Hillegers MHJ, Hoekstra PJ, Holmes AJ, Hong LE, Hopkins WD, Hulshoff Pol HE, Jernigan TL, Jönsson EG, Kahn RS, Kennedy MA, Kircher TTJ, Kochunov P, Kwok JBJ, Le Hellard S, Loughland CM, Martin NG, Martinot JL, McDonald C, McMahon KL, Meyer-Lindenberg A, Michie PT, Morey RA, Mowry B, Nyberg L, Oosterlaan J, Ophoff RA, Pantelis C, Paus T, Pausova Z, Penninx BWJH, Polderman TJC, Posthuma D, Rietschel M, Roffman JL, Rowland LM, Sachdev PS, Sämann PG, Schall U, Schumann G, Scott RJ, Sim K, Sisodiya SM, Smoller JW, Sommer IE, St Pourcain B, Stein DJ, Toga AW, Trollor JN, Van der Wee NJA, van 't Ent D, Völzke H, Walter H, Weber B, Weinberger DR, Wright MJ, Zhou J, Stein JL, Thompson PM, Medland SE; Enhancing NeuroImaging Genetics through Meta-Analysis Consortium (ENIGMA)—Genetics working group. The genetic architecture of the human cerebral cortex. Science, 367(6484):1340(eaay6690), 2020.3 DOI:10.1126/science.aay6690
  5. Yasuda Y, Okada N, Nemoto K, Fukunaga M, Yamamori H, Ohi K, Koshiyama D, Kudo N, Shiino T, Morita S, Morita K, Azechi H, Fujimoto M, Miura K, Watanabe Y, Kasai K, Hashimoto R. Brain morphological and functional features in cognitive subgroups of Schizophrenia. Psychiatry Clin Neurosci, 74(3):191-203, 2020.3 DOI:10.1111/pcn.12963
  6. Matsumura K, Seiriki K, Okada S, Nagase M, Ayabe S, Yamada I, Furuse T, Shibuya H, Yasuda Y, Yamamori H, Fujimoto M, Nagayasu K, Yamamoto K, Kitagawa K, Miura H, Gotoda-Nishimura N, Igarashi H, Hayashida M, Baba M, Kondo M, Hasebe S, Ueshima K, Kasai A, Ago Y, Hayata-Takano A, Shintani N, Iguchi T, Sato M, Yamaguchi S, Tamura M, Wakana S, Yoshiki A, Watabe AM, Okano H, Takuma K, Hashimoto R, Hashimoto H, Nakazawa T. Pathogenic POGZ mutation causes impaired cortical development and reversible autism-like phenotypes. Nat. Commun. 11(1):859 2020.2 DOI:10.1038/s41467-020-14697-z
  7. Nemoto K, Shimokawa T, Fukunaga M, Yamashita F, Tamura M, Yamamori H, Yasuda Y, Azechi H, Kudo N, Watanabe Y, Kido M, Takahashi T, Koike S, Okada N, Hirano Y, Onitsuka T, Yamasue H, Suzuki M, Kasai K, Hashimoto R, Arai T. Differentiation of schizophrenia using structural MRI with consideration of scanner differences: A real-world multi-site study. Psychiatry Clin Neurosci, 74(1):56-63, 2020.1 DOI:10.1111/pcn.12934

2019年

  1. Koshiyama D, Fukunaga M, Okada N, Morita K, Nemoto K, Usui K, Yamamori H, Yasuda Y, Fujimoto M, Kudo N, Azechi H, Watanabe Y, Hashimoto N, Narita H, Kusumi I, Ohi K, Shimada T, Kataoka Y, Yamamoto M, Ozaki N, Okada G, Okamoto Y, Harada K, Matsuo K, Yamasue H, Abe O, Hashimoto R, Takahashi T, Hori T, Nakataki M, Onitsuka T, Holleran L, Jahanshad N, van Erp TG, Turner JA, Donohoe G, Thompson PM, Kasai K, Hashimoto R, COCORO. White matter microstructural alterations across four major psychiatric disorders: mega-analysis study in 2937 individuals. Mol Psychiatry, 2019.11 DOI: 10.1038/s41380-019-0553-7
  2. Baba M, Yokoyama K, Seiriki K, Naka Y, Matsumura K, Kondo M, Yamamoto K, Hayashida M, Kasai A, Ago Y, Nagayasu K, Hayata-Takano A, Takahashi A, Yamaguchi S, Mori D, Ozaki N, Yamamoto T, Takuma K, Hashimoto R, Hashimoto H, Nakazawa T. Psychiatric-disorder-related behavioral phenotypes and cortical hyperactivity in a mouse model of 3q29 deletion syndrome. Neuropsychopharmacology, 44(12):2125-2135, 2019.11 DOI:10.1038/s41386-019-0441-5
  3. Matsumura K, Baba M, Nagayasu K, Yamamoto K, Kondo M, Kitagawa K, Takemoto T, Seiriki K, Kasai A, Ago Y, Hayata-Takano A, Shintani N, Kuriu T, Iguchi T, Sato M, Takuma K, Hashimoto R, Hashimoto H. Autism-associated protein kinase D2 regulates embryonic cortical neuron development. Biochem Biophys Res Commun, 519(3):626-632, 2019.11 DOI:10.1016/j.bbrc.2019.09.048
  4. Takaesu Y, Watanabe K, Numata S, Iwata M, Kudo N, Oishi S, Takizawa T, Nemoto K, Yasuda Y, Tagata H, Tsuboi T, Tsujino N, Hashimoto N, Matsui Y, Hori H, Yamamori H, Sugiyama N, Suwa T, Kishimoto T, Hishimoto A, Usami M, Furihata R, Iwamoto K, Fujishiro H, Nakamura T, Mizuno K, Inagaki T, Katsumoto E, Tomita H, Ohi K, Muraoka H, Atake K, Iida H, Nagasawa T, Fujita J, Yamamura S, Onitsuka T, Murata A, Takayanagi Y, Noda H, Matsumura Y, Takezawa K, Iga J, Ichihashi K, Ogasawara K, Yamada H, Inada K, *Hashimoto R. Improvement of psychiatrists’ clinical knowledge of the treatment guidelines for schizophrenia and major depressive disorders using the “Effectiveness of Guidelines for Dissemination and Education in psychiatric treatment (EGUIDE) ” project: a nationwide dissemination, education and evaluation study. Psychiatry Clin Neurosci, 73(10):642-648, 2019.10 DOI:10.1111/pcn.12911
  5. Nakazawa T, Hashimoto R, Takuma K, Hashimoto H. Current Perspective: Modeling of psychiatric disorders using induced pluripotent stem cell-related technologies. J Pharmacol Sci, 140(4):321-324, 2019.8 DOI:10.1016/j.jphs.2019.06.002
  6. Oya K, Sakuma K, Esumi S, Hashimoto Y, Hatano M, Matsuda Y, Matsui Y, Miyake N, Nomura I, Okuya M, Iwata N, Kato M, Hashimoto R, Mishima K, Watanabe N, Kishi T. Efficacy and safety of lithium and lamotrigine for the maintenance treatment of clinically stable patients with bipolar disorder: A systematic review and meta-analysis of double-blind, randomized, placebo-controlled trials with an enrichment design. Neuropsychopharmacol Rep. 39(3):241-246, 2019.9 DOI: 10.1002/npr2.12056
  7. Ohi K, Sumiyoshi C, Fujino H, Yasuda Y, Yamamori H, Fujimoto M, Sumiyoshi T, *Hashimoto R. A 1.5-year longitudinal study of social activity in patients with schizophrenia. Front Psychiatry, section Schizophrenia. 10:567, 2019.8doi.org/10.3389/fpsyt.2019.00567
  8. Morita K, Miura K, Fujimoto M, Yamamori H, Yasuda Y, Kudo N, Azechi H, OkadaN, Koshiyama D, Shiino T, Fukunaga M, Watanabe Y, Ikeda M, Kasai K, Hashimoto R. Eye movement characteristics of schizophrenia and their association with cortical thickness. Psychiatry Clin Neurosci, Psychiatry Clin Neurosci, 73(8): 508-509, 2019.8 DOI: 10.1111/pcn.12865
  9. Morita K, *Miura K, Fujimoto M, Yamamori H, Yasuda Y, Kudo N, Azechi H, Okada N, Koshiyama D, Ikeda M, Kasai K, *Hashimoto R. Eye movement abnormalities and their association with cognitive impairments in schizophrenia. Schizophr Res, 209:255-262, 2019.7 DOI: 10.1016/j.schres.2018.12.051
  10. Ikeda M, Takahashi A, Kamatani Y, Momozawa Y, Saito T, Kondo K, Shimasaki A, Kawase K, Sakusabe T, Iwayama Y, Toyota T, Wakuda T, Kikuchi M, Kanahara N, Yamamori H, Yasuda Y, Watanabe Y, Hoya S, Aleksic B, Kushima I, Arai H, Takaki M, Hattori K, Kunugi H, Okahisa Y, Ohnuma T, Ozaki N, Someya T, Hashimoto R, Yoshikawa T, Kubo M, Iwata N. Genome-Wide Association Study Detected Novel Susceptibility Genes for Schizophrenia and Shared Trans-Populations/Diseases Genetic Effect. Schizophr Bull, 45(4):824-834, 2019.7 DOI: 10.1093/schbul/sby140
  11. van Erp TGM, Walton E, Hibar DP, Schmaal L, Jiang W, Glahn DC, Pearlson GD, Yao N, Fukunaga M, Hashimoto R 〈10番目109名中), Okada N, Yamamori H, Clark VP, Mueller BA, de Zwarte SMC, Ophoff RA, van Haren NEM, Andreassen OA, Gurholt TP, Gruber O, Kraemer B, Richter A, Calhoun VD, Crespo-Facorro B, Roiz-Santianez R, Tordesillas-Gutierrez D, Loughland C, Catts S, Fullerton JM, Green MJ, Henskens F, Jablensky A, Mowry BJ, Pantelis C, Quide Y, Schall U, Scott RJ, Cairns MJ, Seal M, Tooney PA, Rasser PE, Cooper G, Shannon Weickert C, Weickert TW, Hong E, Kochunov P, Gur RE, Gur RC, Ford JM, Macciardi F, Mathalon DH, Potkin SG, Preda A, Fan F, Ehrlich S, King MD, De Haan L, Veltman DJ, Assogna F, Banaj N, de Rossi P, Iorio M, Piras F, Spalletta G, Pomarol-Clotet E, Kelly S, Ciufolini S, Radua J, Murray R, Marques TR, Simmons A, Borgwardt S, Schonborn-Harrisberger F, Riecher-Rossler A, Smieskova R, Alpert KI, Bertolino A, Bonvino A, Di Giorgio A, Neilson E, Mayer AR, Yun JY, Cannon DM, Lebedeva I, Tomyshev AS, Akhadov T, Kaleda V, Fatouros-Bergman H, Flyckt L; Karolinska Schizophrenia Project, Rosa PGP, Serpa MH, Zanetti MV, Hoschl C, Skoch A, Spaniel F, Tomecek D, McIntosh AM, Whalley HC, Knochel C, Oertel-Knochel V, Howells FM, Stein DJ, Temmingh HS, Uhlmann A, Lopez-Jaramillo C, Dima D, Faskowitz JI, Gutman BA, Jahanshad N, Thompson PM, Turner JA. Reply to: New Meta- and Mega-analyses of Magnetic Resonance Imaging Findings in Schizophrenia: Do They Really Increase Our Knowledge About the Nature of the Disease Process? Biol Psychiatry, 85(7):e35-e39. 2019.4 DOI: 10.1016/j.biopsych.2018.10.003

2018年

  1. Miki K, Nakae A, Shi K, Yasuda Y, Yamamori H, Fujimoto M, Ikeda M, Shibata M, Yukioka M, Hashimoto R. Frequency of mental disorders among chronic pain patients with or without fibromyalgia in Japan. Neuropsychopharmacol Rep, 38(4):167-174, 2018.12 DOI: 10.1002/npr2.12025
  2. Morita K, Miura K, Fujimoto M, Shishido E, Shiino T, Takahashi J, Yamamori H, Yasuda Y, Kudo N, Hirano Y, Koshiyama D, Okada N, Ikeda M, Onitsuka T, Ozaki N, Kasai K, Hashimoto R. Abnormalities of eye movement are associated with work hours in schizophrenia. Schizophr Res, 202:420-422, 2018.12 DOI: 10.1016/j.schres.2018.06.064
  3. Koshiyama D, Fukunaga M, Okada N, Morita K, Nemoto K, Yamashita F, Yamamori H, Yasuda Y, Fujimoto M, Kelly S, Jahanshad N, Kudo N, Azechi H, Watanabe Y, Donohoe G, Thompson PM, Kasai K, *Hashimoto R. Role of frontal white matter and corpus callosum on social function in schizophrenia. Schizophr Res, 202:180-187, 2018.12 DOI: 10.1016/j.schres.2018.07.009
  4. Sumiyoshi C, Fujino H, Yamamori H, Kudo N, Azechi H, Fujimoto M, Yasuda Y, Ohi K, Sumiyoshi T, Hashimoto R. Predicting work outcome in patients with schizophrenia: Influence of IQ decline. Schizophr Res, 201:172-179, 2018.11 DOI: 10.1016/j.schres.2018.05.042
  5. van Erp TGM, Walton E, Hibar DP, Schmaal L, Jiang W, Glahn DC, Pearlson GD, Yao N, Fukunaga M, Hashimoto R,(178名中10番目) Okada N, Yamamori H, Bustillo JR, Clark VP, Agartz I, Mueller BA, Cahn W, de Zwarte SMC, Hulshoff Pol HE, Kahn RS, Ophoff RA, van Haren NEM, Andreassen OA, Dale AM, Doan NT, Gurholt TP, Hartberg CB, Haukvik UK, Jorgensen KN, Lagerberg TV, Melle I, Westlye LT, Gruber O, Kraemer B, Richter A, Zilles D, Calhoun VD, Crespo-Facorro B, Roiz-Santianez R, Tordesillas-Gutierrez D, Loughland C, Carr VJ, Catts S, Cropley VL, Fullerton JM, Green MJ, Henskens FA, Jablensky A, Lenroot RK, Mowry BJ, Michie PT, Pantelis C, Quide Y, Schall U, Scott RJ, Cairns MJ, Seal M, Tooney PA, Rasser PE, Cooper G, Shannon Weickert C, Weickert TW, Morris DW, Hong E, Kochunov P, Beard LM, Gur RE, Gur RC, Satterthwaite TD, Wolf DH, Belger A, Brown GG, Ford JM, Macciardi F, Mathalon DH, O'Leary DS, Potkin SG, Preda A, Voyvodic J, Lim KO, McEwen S, Yang F, Tan Y, Tan S, Wang Z, Fan F, Chen J, Xiang H, Tang S, Guo H, Wan P, Wei D, Bockholt HJ, Ehrlich S, Wolthusen RPF, King MD, Shoemaker JM, Sponheim SR, De Haan L, Koenders L, Machielsen MW, van Amelsvoort T, Veltman DJ, Assogna F, Banaj N, de Rossi P, Iorio M, Piras F, Spalletta G, McKenna PJ, Pomarol-Clotet E, Salvador R, Corvin A, Donohoe G, Kelly S, Whelan CD, Dickie EW, Rotenberg D, Voineskos AN, Ciufolini S, Radua J, Dazzan P, Murray R, Reis Marques T, Simmons A, Borgwardt S, Egloff L, Harrisberger F, Riecher-Rossler A, Smieskova R, Alpert KI, Wang L, Jonsson EG, Koops S, Sommer IEC, Bertolino A, Bonvino A, Di Giorgio A, Neilson E, Mayer AR, Stephen JM, Kwon JS, Yun JY, Cannon DM, McDonald C, Lebedeva I, Tomyshev AS, Akhadov T, Kaleda V, Fatouros-Bergman H, Flyckt L; Karolinska Schizophrenia Project, Busatto GF, Rosa PGP, Serpa MH, Zanetti MV, Hoschl C, Skoch A, Spaniel F, Tomecek D, Hagenaars SP, McIntosh AM, Whalley HC, Lawrie SM, Knochel C, Oertel-Knochel V, Stablein M, Howells FM, Stein DJ, Temmingh HS, Uhlmann A, Lopez-Jaramillo C, Dima D, McMahon A, Faskowitz JI, Gutman BA, Jahanshad N, Thompson PM, Turner JA. Cortical Brain Abnormalities in 4474 Individuals With Schizophrenia and 5098 Control Subjects via the Enhancing Neuro Imaging Genetics Through Meta Analysis (ENIGMA) Consortium. Biol Psychiatry, 84(9):644-654, 2018.11 DOI: 10.1016/j.biopsych.2018.04.023
  6. Ohi K, Sumiyoshi C, Fujino H, Yasuda Y, Yamamori H, Fujimoto M, Shiino T, Sumiyoshi T, Hashimoto R. Genetic Overlap between General Cognitive Function and Schizophrenia: A Review of Cognitive GWASs. Int J Mol Sci, 19(12):3822, 2018.11 DOI: 10.3390/ijms19123822
  7. Numata S, Umehara H, Ohmori T, Hashimoto R. Clozapine Pharmacogenetic Studies in Schizophrenia: Efficacy and Agranulocytosis. Front Pharmacol, 9:1049, 2018.9 DOI: 10.3389/fphar.2018.01049
  8. Kushima I, Aleksic B, Nakatochi M, Shimamura T, Okada T, Uno Y, Morikawa M, Ishizuka K, Shiino T, Kimura H, Arioka Y, Yoshimi A, Takasaki Y, Yu Y, Nakamura Y, Yamamoto M, Iidaka T, Iritani S, Inada T, Ogawa N, Shishido E, Torii Y, Kawano N, Omura Y, Yoshikawa T, Uchiyama T, Yamamoto T, Ikeda M, Hashimoto R,(80名中29番目) Yamamori H, Yasuda Y, Someya T, Watanabe Y, Egawa J, Nunokawa A, Itokawa M, Arai M, Miyashita M, Kobori A, Suzuki M, Takahashi T, Usami M, Kodaira M, Watanabe K, Sasaki T, Kuwabara H, Tochigi M, Nishimura F, Yamasue H, Eriguchi Y, Benner S, Kojima M, Yassin W, Munesue T, Yokoyama S, Kimura R, Funabiki Y, Kosaka H, Ishitobi M, Ohmori T, Numata S, Yoshikawa T, Toyota T, Yamakawa K, Suzuki T, Inoue Y, Nakaoka K, Goto YI, Inagaki M, Hashimoto N, Kusumi I, Son S, Murai T, Ikegame T, Okada N, Kasai K, Kunimoto S, Mori D, Iwata N, Ozaki N. Comparative Analyses of Copy-Number Variation in Autism Spectrum Disorder and Schizophrenia Reveal Etiological Overlap and Biological Insights. Cell Rep, 24(11):2838-2856, 2018.9 DOI: 10.1016/j.celrep.2018.08.022
  9. Zhang Y, Hishimoto A, Otsuka I, Watanabe Y, Numata S, Yamamori H, Boku S, Horai T, Someya T, Ohmori T, Hashimoto R, Sora I. Longer telomeres in elderly schizophrenia are associated with long-term hospitalization in the Japanese population. J Psychiatr Res, 103:161-166, 2018.8 DOI: 10.1016/j.jpsychires.2018.05.014
  10. Kikuchi M, Miura K, Morita K, Yamamori H, Fujimoto M, Ikeda M, Yasuda Y, Nakaya A, *Hashimoto R. Genome-wide Association Analysis of Eye Movement Dysfunction in Schizophrenia. Sci Rep, 8(1):12347, 2018.8 DOI: 10.1038/s41598-018-30646-9
  11. Kudo N, Yamamori H, Ishima T, Nemoto K, Yasuda Y, Fujimoto M, Azechi H, Niitsu T, Numata S, Ikeda M, Iyo M, Ohmori T, Fukunaga M, Watanabe Y, Hashimoto K, Hashimoto R. Plasma Levels of Soluble Tumor Necrosis Factor Receptor 2 (sTNFR2) Are Associated with Hippocampal Volume and Cognitive Performance in Patients with Schizophrenia. Int J Neuropsychopharmacol, 21(7):631-639, 2018.7 DOI: 10.1093/ijnp/pyy013
  12. Hibar DP, Cheung JW, Medland SE, Mufford MS, Jahanshad N, Dalvie S, Ramesar R, Stewart E, van den Heuvel OA, Pauls DL, Knowles JA, Stein DJ, Thompson PM; Enhancing Neuro Imaging Genetics through Meta Analysis (ENIGMA) Consortium and International Obsessive Compulsive Disorder Foundation Genetics Collaborative (IOCDF-GC). Significant concordance of genetic variation that increases both the risk for obsessive-compulsive disorder and the volumes of the nucleus accumbens and putamen. Br J Psychiatry, 213(1):430-436, 2018.7 DOI: 10.1192/bjp.2018.62
  13. Ursini G, Punzi G, Chen Q, Marenco S, Robinson JF, Porcelli A, Hamilton EG, Mitjans M, Maddalena G, Begemann M, Seidel J, Yanamori H, Jaffe AE, Berman KF, Egan MF, Straub RE, Colantuoni C, Blasi G, Hashimoto R, Rujescu D, Ehrenreich H, Bertolino A, Weinberger DR. Convergence of placenta biology and genetic risk for schizophrenia. Nat Med, 24(6):792-801, 2018.6 DOI: 10.1038/s41591-018-0021-y
  14. Reinbold CS, Forstner AJ, Hecker J, Fullerton JM, Hoffmann P, Hou L, Heilbronner U, Degenhardt F, Adli M, Akiyama K, Akula N, Ardau R, Arias B, Backlund L, Benabarre A, Bengesser S, Bhattacharjee AK, Biernacka JM, Birner A, Marie-Claire C, Cervantes P, Chen GB, Chen HC, Chillotti C, Clark SR, Colom F, Cousins DA, Cruceanu C, Czerski PM, Dayer A, Etain B, Falkai P, Frisen L, Gard S, Garnham JS, Goes FS, Grof P, Gruber O, Hashimoto R,(121名中39番目) Hauser J, Herms S, Jamain S, Jimenez E, Kahn JP, Kassem L, Kittel-Schneider S, Kliwicki S, Konig B, Kusumi I, Lackner N, Laje G, Landen M, Lavebratt C, Leboyer M, Leckband SG, Lopez Jaramillo CA, MacQueen G, Manchia M, Martinsson L, Mattheisen M, McCarthy MJ, McElroy SL, Mitjans M, Mondimore FM, Monteleone P, Nievergelt CM, Osby U, Ozaki N, Perlis RH, Pfennig A, Reich-Erkelenz D, Rouleau GA, Schofield PR, Schubert KO, Schweizer BW, Seemuller F, Severino G, Shekhtman T, Shilling PD, Shimoda K, Simhandl C, Slaney CM, Smoller JW, Squassina A, Stamm TJ, Stopkova P, Tighe SK, Tortorella A, Turecki G, Volkert J, Witt SH, Wright AJ, Young LT, Zandi PP, Potash JB, DePaulo JR, Bauer M, Reininghaus E, Novak T, Aubry JM, Maj M, Baune BT, Mitchell PB, Vieta E, Frye MA, Rybakowski JK, Kuo PH, Kato T, Grigoroiu-Serbanescu M, Reif A, Del Zompo M, Bellivier F, Schalling M, Wray NR, Kelsoe JR, Alda M, McMahon FJ, Schulze TG, Rietschel M, Nothen MM, Cichon S. Analysis of the Influence of microRNAs in Lithium Response in Bipolar Disorder. Front Psychiatry, 9:207, 2018.5 DOI: 10.3389/fpsyt.2018.00207
  15. Kelly S, Jahanshad N, Zalesky A, Kochunov P, Agartz I, Alloza C, Andreassen OA, Arango C, Banaj N, Bouix S, Bousman CA, Brouwer RM, Bruggemann J, Bustillo J, Cahn W, Calhoun V, Cannon D, Carr V, Catts S, Chen J, Chen JX, Chen X, Chiapponi C, Cho KK, Ciullo V, Corvin AS, Crespo-Facorro B, Cropley V, De Rossi P, Diaz-Caneja CM, Dickie EW, Ehrlich S, Fan FM, Faskowitz J, Fatouros-Bergman H, Flyckt L, Ford JM, Fouche JP, Fukunaga M, Gill M, Glahn DC, Gollub R, Goudzwaard ED, Guo H, Gur RE, Gur RC, Gurholt TP, Hashimoto R, Hatton SN, Henskens FA, Hibar DP, Hickie IB, Hong LE, Horacek J, Howells FM, Hulshoff Pol HE, Hyde CL, Isaev D, Jablensky A, Jansen PR, Janssen J, Jonsson EG, Jung LA, Kahn RS, Kikinis Z, Liu K, Klauser P, Knochel C, Kubicki M, Lagopoulos J, Langen C, Lawrie S, Lenroot RK, Lim KO, Lopez-Jaramillo C, Lyall A, Magnotta V, Mandl RCW, Mathalon DH, McCarley RW, McCarthy-Jones S, McDonald C, McEwen S, McIntosh A, Melicher T, Mesholam-Gately RI, Michie PT, Mowry B, Mueller BA, Newell DT, O'Donnell P, Oertel-Knochel V, Oestreich L, Paciga SA, Pantelis C, Pasternak O, Pearlson G, Pellicano GR, Pereira A, Pineda Zapata J, Piras F, Potkin SG, Preda A, Rasser PE, Roalf DR, Roiz R, Roos A, Rotenberg D, Satterthwaite TD, Savadjiev P, Schall U, Scott RJ, Seal ML, Seidman LJ, Shannon Weickert C, Whelan CD, Shenton ME, Kwon JS, Spalletta G, Spaniel F, Sprooten E, Stablein M, Stein DJ, Sundram S, Tan Y, Tan S, Tang S, Temmingh HS, Westlye LT, Tonnesen S, Tordesillas-Gutierrez D, Doan NT, Vaidya J, van Haren NEM, Vargas CD, Vecchio D, Velakoulis D, Voineskos A, Voyvodic JQ, Wang Z, Wan P, Wei D, Weickert TW, Whalley H, White T, Whitford TJ, Wojcik JD, Xiang H, Xie Z, Yamamori H, Yang F, Yao N, Zhang G, Zhao J, van Erp TGM, Turner J, Thompson PM, Donohoe G. Widespread white matter microstructural differences in schizophrenia across 4,322 individuals: results from the ENIGMA Schizophrenia DTI Working Group. Mol Psychiatry, 23(5):1261-1269, 2018.5 DOI: 10.1038/mp.2017.170
  16. Tomioka Y, Numata S, Kinoshita M, Umehara H, Watanabe S, Nakataki M, Iwayama Y, Toyota T, Ikeda M, Yamamori H, Shimodera S, Tajima A, Hashimoto R, Iwata N, Yoshikawa T, Ohmori T. Decreased serum pyridoxal levels in schizophrenia: meta-analysis and Mendelian randomization analysis. J Psychiatry Neurosci, 43(2):170053,2018.5 DOI:10.1503/jpn.170053
  17. Hashimoto R. Blood biomarkers for neuropsychiatric diseases. Psychiatry Clin Neurosci, 2018.3;72(3):139, 2018.3 DOI: 10.1111/pcn.12624
  18. Sumiyoshi C, Fujino H, Sumiyoshi T, Yasuda Y, Yamamori H, Fujimoto M, Hashimoto R. Semantic Memory Organization in Japanese Patients with Schizophrenia Examined with Category Fluency. Frontiers in Psychiatry, section Psychopathology, 9:87, 2018.3 DOI: 10.3389/fpsyt.2018.00087
  19. Ikeda M, Takahashi A, Kamatani Y, Okahisa Y, Kunugi H, Mori N, Sasaki T, Ohmori T, Okamoto Y, Kawasaki H, Shimodera S, Kato T, Yoneda H, Yoshimura R, Iyo M, Matsuda K, Akiyama M, Ashikawa K, Kashiwase K, Tokunaga K, Kondo K, Saito T, Shimasaki A, Kawase K, Kitajima T, Matsuo K, Itokawa M, Someya T, Inada T, Hashimoto R, Inoue T, Akiyama K, Tanji H, Arai H, Kanba S, Ozaki N, Kusumi I, Yoshikawa T, Kubo M, Iwata N, COSMO team. A genome-wide association study identifies two novel susceptibility loci and trans population polygenicity associated with bipolar disorder. Mol Psychiatry, 23(3):639-647, 2018.3 DOI: 10.1038/mp.2016.259
  20. International Consortium on Lithium Genetics (ConLi+Gen), Amare AT, Schubert KO, Hou L, Clark SR, Papiol S, Heilbronner U, Degenhardt F, Tekola-Ayele F, Hsu YH, Shekhtman T, Adli M, Akula N, Akiyama K, Ardau R, Arias B, Aubry JM, Backlund L, Bhattacharjee AK, Bellivier F, Benabarre A, Bengesser S, Biernacka JM, Birner A, Brichant-Petitjean C, Cervantes P, Chen HC, Chillotti C, Cichon S, Cruceanu C, Czerski PM, Dalkner N, Dayer A, Del Zompo M, DePaulo JR, Etain B, Falkai P, Forstner AJ, Frisen L, Frye MA, Fullerton JM, Gard S, Garnham JS, Goes FS, Grigoroiu-Serbanescu M, Grof P, Hashimoto R, Hauser J, Herms S, Hoffmann P, Hofmann A, Jamain S, Jimenez E, Kahn JP, Kassem L, Kuo PH, Kato T, Kelsoe J, Kittel-Schneider S, Kliwicki S, Konig B, Kusumi I, Laje G, Landen M, Lavebratt C, Leboyer M, Leckband SG, Tortorella A, Manchia M, Martinsson L, McCarthy MJ, McElroy S, Colom F, Mitjans M, Mondimore FM, Monteleone P, Nievergelt CM, Nothen MM, Novak T, O'Donovan C, Ozaki N, Osby U, Pfennig A, Potash JB, Reif A, Reininghaus E, Rouleau GA, Rybakowski JK, Schalling M, Schofield PR, Schweizer BW, Severino G, Shilling PD, Shimoda K, Simhandl C, Slaney CM, Squassina A, Stamm T, Stopkova P, Maj M, Turecki G, Vieta E, Volkert J, Witt S, Wright A, Zandi PP, Mitchell PB, Bauer M, Alda M, Rietschel M, McMahon FJ, Schulze TG, Baune BT. Association of Polygenic Score for Schizophrenia and HLA Antigen and Inflammation Genes With Response to Lithium in Bipolar Affective Disorder: A Genome-Wide Association Study. JAMA Psychiatry, 1;75(1):65-74, 2018.1 DOI: 10.1001/jamapsychiatry.2017.3433
  21. Koshiyama D, Fukunaga M, Okada N, Yamashita F, Yamamori H, Yasuda Y, Fujimoto M, Ohi K, Fujino H, Watanabe Y, Kasai K, Hashimoto R. Role of subcortical structures on cognitive and social function in schizophrenia. Sci Rep, 19;8(1):1183, 2018.1 DOI: 10.1038/s41598-017-18950-2
  22. Takata A, Miyake N, Tsurusaki Y, Fukai R, Miyatake S, Koshimizu E, Kushima I, Okada T, Morikawa M, Uno Y, Ishizuka K, Nakamura K, Tsujii M, Yoshikawa T, Toyota T, Okamoto N, Hiraki Y, Hashimoto R, Yasuda Y, Saitoh S, Ohashi K, Sakai Y, Ohga S, Hara T, Kato M, Nakamura K, Ito A, Seiwa C, Shirahata E, Osaka H, Matsumoto A, Takeshita S, Tohyama J, Saikusa T, Matsuishi T, Nakamura T, Tsuboi T, Kato T, Suzuki T, Saitsu H, Nakashima M, Mizuguchi T, Tanaka F, Mori N, Ozaki N, Matsumoto N. Integrative analyses of de novo mutations provide deeper biological insights in autism spectrum disorder. Cell Rep, 16;22(3):734-747, 2018.1 DOI: 10.1016/j.celrep.2017.12.074
  23. Koshiyama D, Fukunaga M, Okada N,Yamashita F, Yamamori H, Yasuda Y, Fujimoto M, Ohi K, Fujino H, Watanabe Y, Kasai K, Hashimoto R. Subcortical association with memory performance in schizophrenia: a structural magnetic resonance imaging study. Transl Psychiatry. 8(1):20, 2018.1 DOI: 10.1038/s41398-017-0069-3
  24. Walton E, Hibar DP, van Erp TGM, Potkin SG, Roiz-Santianez R, Crespo-Facorro B, Suarez-Pinilla P, van Haren NEM, de Zwarte SMC, Kahn RS, Cahn W, Doan NT, Jorgensen KN, Gurholt TP, Agartz I, Andreassen OA, Westlye LT, Melle I, Berg AO, Morch-Johnsen L, Farden A, Flyckt L, Fatouros-Bergman H, Jonsson EG, Hashimoto R, Yamamori H, Fukunaga M, Jahanshad N, De Rossi P, Piras F, Banaj N, Spalletta G, Gur RE, Gur RC, Wolf DH, Satterthwaite TD, Beard LM, Sommer IE, Koops S, Gruber O, Richter A, Kramer B, Kelly S, Donohoe G, McDonald C, Cannon DM, Corvin A, Gill M, Di Giorgio A, Bertolino A, Lawrie S, Nickson T, Whalley HC, Neilson E, Calhoun VD, Thompson PM, Turner JA, Ehrlich S, Karolinska Schizophrenia Project consortium (KaSP). Prefrontal cortical thinning links to negative symptoms in schizophrenia via the ENIGMA consortium. Psychol Med, 48(1):82-94, 2018.1 DOI: 10.1017/S0033291717001283

2017年

  1. Ohi K, Sumiyoshi C, Fujino H, Yasuda Y, Yamamori H, Fujimoto M, Sumiyoshi T, *Hashimoto R. A Brief Assessment of Intelligence Decline in Schizophrenia As Represented by the Difference between Current and Premorbid Intellectual Quotient. Front Psychiatry, 8:293. 2017.12 DOI: 10.3389/fpsyt.2017.00293
  2. Hashimoto N, Ito Y, Okada N, Yamamori H, Yasuda Y, Fujimoto M, Kudo N, Takemura A, Son S, Narita H, Yamamoto M, Tha KK, Katsuki A, Ohi K, Yamashita F, Koike S, Takahashi T, Nemoto K, Fukunaga M, Onitsuka T, Watanabe Y, Yamasue H, Suzuki M, Kasai K, Kusumi I, Hashimoto R, for COCORO. The effect of duration of illness and antipsychotics on subcortical volumes in schizophrenia: Analysis of 778 subjects. NeuroImage Clin, 17;563-569, 2017.11 DOI: 10.1016/j.nicl.2017.11.004
  3. Guadalupe T, Mathias SR, vanErp TG, Whelan CD, Zwiers MP, Abe Y, Abramovic L, Agartz I, Andreassen OA, Arias-Vasquez A, Aribisala BS, Armstrong NJ, Arolt V, Artiges E, Ayesa-Arriola R, Baboyan VG, Banaschewski T, Barker G, Bastin ME, Baune BT, Blangero J, Bokde AL, Boedhoe PS, Bose A, Brem S, Brodaty H, Bromberg U, Brooks S, Buchel C, Buitelaar J, Calhoun VD, Cannon DM, Cattrell A, Cheng Y, Conrod PJ, Conzelmann A, Corvin A, Crespo-Facorro B, Crivello F, Dannlowski U, de Zubicaray GI, de Zwarte SM, Deary IJ, Desrivieres S, Doan NT, Donohoe G, Dorum ES, Ehrlich S, Espeseth T, Fernandez G, Flor H, Fouche JP, Frouin V, Fukunaga M, Gallinat J, Garavan H, Gill M, Suarez AG, Gowland P, Grabe HJ, Grotegerd D, Gruber O, Hagenaars S, Hashimoto R, Hauser TU, Heinz A, Hibar DP, Hoekstra PJ, Hoogman M, Howells FM, Hu H, Hulshoff Pol HE, Huyser C, Ittermann B, Jahanshad N, Jonsson EG, Jurk S, Kahn RS, Kelly S, Kraemer B, Kugel H, Kwon JS, Lemaitre H, Lesch KP, Lochner C, Luciano M, Marquand AF, Martin NG, Martinez-Zalacain I, Martinot JL, Mataix-Cols D, Mather K, McDonald C, McMahon KL, Medland SE, Menchon JM, Morris DW, Mothersill O, Maniega SM, Mwangi B, Nakamae T, Nakao T, Narayanaswaamy JC, Nees F, Nordvik JE, Onnink AM, Opel N, Ophoff R, Paillere Martinot ML, Papadopoulos Orfanos D, Pauli P, Paus T, Poustka L, Reddy JY, Renteria ME, Roiz-Santianez R, Roos A, Royle NA, Sachdev P, Sanchez-Juan P, Schmaal L, Schumann G, Shumskaya E, Smolka MN, Soares JC, Soriano-Mas C, Stein DJ, Strike LT, Toro R, Turner JA, Tzourio-Mazoyer N, Uhlmann A, Hernandez MV, van den Heuvel OA, van der Meer D, van Haren NE, Veltman DJ, Venkatasubramanian G, Vetter NC, Vuletic D, Walitza S, Walter H, Walton E, Wang Z, Wardlaw J, Wen W, Westlye LT, Whelan R, Wittfeld K, Wolfers T, Wright MJ, Xu J, Xu X, Yun JY, Zhao J, Franke B, Thompson PM, Glahn DC, Mazoyer B, Fisher SE, Francks C. Human subcortical brain asymmetries in 15,847 people worldwide reveal effects of age and sex. Brain Imaging and Behaviour, 11(5):1497-1514, 2017.10 DOI:10.1007/s11682-016-9629-z
  4. Ohgidani M, Kato TA, Hosoi M, Tsuda M, Hayakawa K, Hayaki C, Iwaki R, Sagata N, Hashimoto R, Inoue K, Sudo N, Kanba S. Fibromyalgia and microglial TNF-α: Translational research using human blood induced microglia-like cells. Sci Rep, 7(1):11882, 2017.9 DOI: 10.1038/s41598-017-11506-4
  5. Saito T, Ikeda M, Hashimoto R, Clozapine Pharmacogenomics Consortium of Japan (CPC-J), Iwata N. Transethnic replication study to assess the association between clozapine-induced agranulocytosis/granulocytopenia and genes at 12p12.2 in a Japanese population. Biol Psychiatry, 82(1):e9-e10, 2017.7 DOI: 10.1016/j.biopsych.2016.12.009
  6. Seiriki K, Kasai A, Hashimoto T, Schulze W, Niu M, Yamaguchi S, Nakazawa T, Inoue K, Uezono S, Takada M, Naka Y, Igarashi H, Tanuma M, Waschek JA, Ago Y, Tanaka KF, Hayata-Takano A, Nagayasu K, Shintani N, Hashimoto R, Kunii Y, Hino M, Matsumoto J, Yabe H, Nagai T, Fujita K, Matsuda T, Takuma K, Baba A, Hashimoto H. High-speed and scalable whole-brain imaging in rodents and primates. Neuron, 94:1085?1100, 2017.6 DOI:10.1016/j.neuron.2017.05.017
  7. Fujino H, Sumiyoshi C, Yasuda Y, Yamamori H, Fujimoto M, Fukunaga M, Miura K, Takebayashi Y, Okada N, Isomura S, Kawano N, Toyomaki A, Kuga H, Isobe M, Oya K, Okahisa Y, Takaki M, Hashimoto N, Kato M, Onitsuka T, Ueno T, Ohnuma T, Kasai K, Ozaki N, Sumiyoshi T, Imura O, *Hashimoto R. Estimated cognitive decline in patients with schizophrenia: a multi-center study. Psychiatry Clin Neurosci, 71(5):294-300, 2017.5 DOI: 10.1111/pcn.12474
  8. Walton E, Hibar DP, van Erp TGM, Potkin SG, Roiz-Santianez R,Crespo-Facorro B, Suarez-Pinilla P, Van Haren NEM,de Zwarte SMC, Kahn RS, Cahn W, Doan NT, Jorgensen KN,Gurholt TP, Agartz I, Andreassen OA, Westlye LT, Melle I, Berg AO, Morch-Johnsen L, Farden A, Flyckt L, Fatouros-Bergman H, Karolinska Schizophrenia Project Consortium (KaSP), Jonsson EG, Hashimoto R, Yamamori H, Fukunaga M, Preda A, De Rossi P, Piras F, Banaj N, Piras F, Ciullo V, Spalletta G, Gur RE, Gur RC, Wolf DH, Satterthwaite TD, Beard LM, Sommer IE, Koops S, Gruber O, Richter A, Kramer B, Kelly S, Donohoe G, McDonald C, Cannon DM, Corvin A, Gill M, Di Giorgio A, Bertolino A, Lawrie S, Nickson T, Whalley HC, Neilson E, Calhoun VD, Thompson PM, Turner JA, Ehrlich S. Positive symptoms associate with cortical thinning in the superior temporal gyrus via the ENIGMA-Schizophrenia consortium. Acta Psychiatr Scand, 135(5):439-447, 2017.5 DOI: 10.1111/acps.12718
  9. Yamaki N, Hishimoto A, Otsuka I, Sasada T, Boku S, Saito T, Yasuda Y, Yamamori H, Ikeda M, Ikeda M, Sora I, Iwata N, *Hashimoto R. Optimizing Outcomes in Clozapine Rechallenge Following Neutropenia Using Human Leukocyte Antigen Typing: A Case Report. Psychiatry Clin Neurosci, 71(4):289-290, 2017.4 DOI: 10.1111/pcn.12505
  10. Kinoshita M, Numata S, Tajima A, Yamamori H, Yasuda Y, Fujimoto M, Watanabe S, Umehara H, Shimodera S, Nakazawa T, Kikuchi M, Nakaya A, Hashimoto H, Imoto I, Hashimoto R, Ohmori T. Effect of clozapine on DNA methylation in peripheral leukocytes frompatients with treatment-resistant schizophrenia. Int J Mol Sci, 18(3):632, 2017.3 DOI:10.3390/ijms18030632
  11. Nakazawa T, Kikuchi M, Ishikawa M, Yamamori H, Nagayasu K, Matsumoto T, Fujimoto M, Yasuda Y, Fujiwara M, Okada S, Matsumura K, Kasai A, Hayata-Takano A, Shintani N, Numata S, Takuma K, Akamatsu W, Okano H, Nakaya A, Hashimoto H, *Hashimoto R. Differential gene expression profiles in neurons generated from lymphoblastoid B-cell line-derived iPS cells from monozygotic twin cases with treatment-resistant schizophrenia and discordant responses to clozapine. Schizophr Res, 181:75-82, 2017.3 DOI:10.1016/j.schres.2016.10.012
  12. Ikawa D, Makinodan M, Iwata K, Ohgidani M, Kato T, Yamashita Y, Yamamuro K, Kimoto S, Toritsuka M, Yamauchi T, Fukami S, Yoshino H, Okumura K, Tanaka T, Wanaka A, Owada Y, Tsujii M, Sugiyama T, Tsuchiya K, Mori N, Hashimoto R, Matsuzaki H, Kanba S, Kishimoto T. Microglia-derived neuregulin expression in psychiatric disorders. Brain Behav Immun, 61:375-385, 2017.3 DOI: 10.1016/j.bbi.2017.01.003
  13. Sakamoto Y, Kioka H, Hashimoto R, Takeda S, Ohtani T, Yamaguchi O, Wasa M, Nakatani S, Sakata Y. Cardiogenic shock caused by left mid-ventricular obstruction in a patient with anorexia nervosa; A novel cardiac manifestation of refeeding syndrome. Nutrition, 35:148-150, 2017.3 DOI: 10.1016/j.nut.2016.12.017
  14. Kushima I, Aleksic B, Nakatochi M, Shimamura T, Shiino T, Yoshimi A, Kimura H, Takasaki Y, Wang C, Xing J, Ishizuka K, Oya-Ito T, Nakamura Y, Arioka Y, Maeda T, Yamamoto M, Yoshida M, Noma H, Hamada S, Morikawa M, Uno Y, Okada T, Iidaka T, Iritani S, Yamamoto T, Miyashita M, Kobori A, Arai M, Itokawa M, Cheng MC, Chuang YA, Chen CH, Suzuki M, Takahashi T, Hashimoto R, Yamamori H, Yasuda Y, Watanabe Y, Nunokawa A, Someya T, Ikeda M, Toyota T, Yoshikawa T, Numata S, Ohmori T, Kunimoto S, Mori D, Iwata N, Ozaki N. High-resolution copy number variation analysis of schizophrenia in Japan. Mol Psychiatry, 22(3):430-440, 2017.3 DOI: 10.1038/mp.2016.88
  15. Morita K, Miura K, Fujimoto M, Yamamori H, Yasuda Y, Iwase M, Kasai K, *Hashimoto R. Eye movement as a biomarker of schizophrenia:Using an integrated eye movement score. Psychiatry Clin Neurosci, 71(2):104-114, 2017.2 DOI:10.1111/pcn.12460
  16. Hibar DP, Adams HH, Jahanshad N, Chauhan G, Stein JL, Hofer E, Renteria ME, Bis JC, Arias-Vasquez A, Ikram MK, Desrivieres S, Vernooij MW, Abramovic L, Alhusaini S, Amin N, Andersson M, Arfanakis K, Aribisala BS, Armstrong NJ, Athanasiu L, Axelsson T, Beecham AH, Beiser A, Bernard M, Blanton SH, Bohlken MM, Boks MP, Bralten J, Brickman AM, Carmichael O, Chakravarty MM, Chen Q, Ching CR, Chouraki V, Cuellar-Partida G, Crivello F, Den Braber A, Doan NT, Ehrlich S, Giddaluru S, Goldman AL, Gottesman RF, Grimm O, Griswold ME, Guadalupe T, Gutman BA, Hass J, Haukvik UK, Hoehn D, Holmes AJ, Hoogman M, Janowitz D, Jia T, Jorgensen KN, Karbalai N, Kasperaviciute D, Kim S, Klein M, Kraemer B, Lee PH, Liewald DC, Lopez LM, Luciano M, Macare C, Marquand AF, Matarin M, Mather KA, Mattheisen M, McKay DR, Milaneschi Y, Munoz Maniega S, Nho K, Nugent AC, Nyquist P, Loohuis LM, Oosterlaan J, Papmeyer M, Pirpamer L, Putz B, Ramasamy A, Richards JS, Risacher SL, Roiz-Santianez R, Rommelse N, Ropele S, Rose EJ, Royle NA, Rundek T, Samann PG, Saremi A, Satizabal CL, Schmaal L, Schork AJ, Shen L, Shin J, Shumskaya E, Smith AV, Sprooten E, Strike LT, Teumer A, Tordesillas-Gutierrez D, Toro R, Trabzuni D, Trompet S, Vaidya D, Van der Grond J, Van der Lee SJ, Van der Meer D, Van Donkelaar MM, Van Eijk KR, Van Erp TG, Van Rooij D, Walton E, Westlye LT, Whelan CD, Windham BG, Winkler AM, Wittfeld K, Woldehawariat G, Wolf C, Wolfers T, Yanek LR, Yang J, Zijdenbos A, Zwiers MP, Agartz I, Almasy L, Ames D, Amouyel P, Andreassen OA, Arepalli S, Assareh AA, Barral S, Bastin ME, Becker DM, Becker JT, Bennett DA, Blangero J, van Bokhoven H, Boomsma DI, Brodaty H, Brouwer RM, Brunner HG, Buckner RL, Buitelaar JK, Bulayeva KB, Cahn W, Calhoun VD, Cannon DM, Cavalleri GL, Cheng CY, Cichon S, Cookson MR, Corvin A, Crespo-Facorro B, Curran JE, Czisch M, Dale AM, Davies GE, De Craen AJ, De Geus EJ, De Jager PL, De Zubicaray GI, Deary IJ, Debette S, DeCarli C, Delanty N, Depondt C, DeStefano A, Dillman A, Djurovic S, Donohoe G, Drevets WC, Duggirala R, Dyer TD, Enzinger C, Erk S, Espeseth T, Fedko IO, Fernandez G, Ferrucci L, Fisher SE, Fleischman DA, Ford I, Fornage M, Foroud TM, Fox PT, Francks C, Fukunaga M, Gibbs JR, Glahn DC, Gollub RL, Goring HH, Green RC, Gruber O, Gudnason V, Guelfi S, Haberg AK, Hansell NK, Hardy J, Hartman CA, Hashimoto R, Hegenscheid K, Heinz A, Le Hellard S, Hernandez DG, Heslenfeld DJ, Ho BC, Hoekstra PJ, Hoffmann W, Hofman A, Holsboer F, Homuth G, Hosten N, Hottenga JJ, Huentelman M, Pol HE, Ikeda M, Jack CR Jr, Jenkinson M, Johnson R, Jonsson EG, Jukema JW, Kahn RS, Kanai R, Kloszewska I, Knopman DS, Kochunov P, Kwok JB, Lawrie SM, Lemaitre H, Liu X, Longo DL, Lopez OL, Lovestone S, Martinez O, Martinot JL, Mattay VS, McDonald C, McIntosh AM, McMahon FJ, McMahon KL, Mecocci P, Melle I, Meyer-Lindenberg A, Mohnke S, Montgomery GW, Morris DW, Mosley TH, Muhleisen TW, Muller-Myhsok B, Nalls MA, Nauck M, Nichols TE, Niessen WJ, Nothen MM, Nyberg L, Ohi K, Olvera RL, Ophoff RA, Pandolfo M, Paus T, Pausova Z, Penninx BW, Pike GB, Potkin SG, Psaty BM, Reppermund S, Rietschel M, Roffman JL, Romanczuk-Seiferth N, Rotter JI, Ryten M, Sacco RL, Sachdev PS, Saykin AJ, Schmidt R, Schmidt H, Schofield PR, Sigursson S, Simmons A, Singleton A, Sisodiya SM, Smith C, Smoller JW, Soininen H, Steen VM, Stott DJ, Sussmann JE, Thalamuthu A, Toga AW, Traynor BJ, Troncoso J, Tsolaki M, Tzourio C, Uitterlinden AG, Hernandez MC, Van der Brug M, van der Lugt A, van der Wee NJ, Van Haren NE, van 't Ent D, Van Tol MJ, Vardarajan BN, Vellas B, Veltman DJ, Volzke H, Walter H, Wardlaw JM, Wassink TH, Weale ME, Weinberger DR, Weiner MW, Wen W, Westman E, White T, Wong TY, Wright CB, Zielke RH, Zonderman AB, Martin NG, Van Duijn CM, Wright MJ, Longstreth WT, Schumann G, Grabe HJ, Franke B, Launer LJ, Medland SE, Seshadri S, Thompson PM, Ikram MA. Novel genetic loci associated with hippocampal volume. Nat Commun, 18;8:13624, 2017.1 DOI: 10.1038/ncomms13624
  17. Thompson P, Andreassen O, Arias-Vasquez A, Bearden C, Boedhoe P, Brouwer R, Buckner R, Buitelaar J, Bulaeva K, Cannon D, Cohen R, Conrod P, Dale A, Deary I, Dennis E, de Reus M, Desrivieres S, Dima D, Donohoe G, Fisher Simon, Fouche JP, Francks C, Frangou S, Franke B, Ganjgahi H, Garavan H, Glahn D, Grabe H, Guadalupe T, Gutman B, Hashimoto R, Hibar D, Holland D, Hoogman M, HulshoffPol H, Hosten N, Jahanshad N, Kelly S, Kochunov P, Kremen W, Lee P, Mackey S, Martin N, Mazoyer B, McDonald C, Medland S, Morey R, Nichols T, Paus T, Pausova Z, Schmaal L, Schumann G, Shen L, Sisodiya S, Smit D, Smoller J, Stein D, Stein J, Toro R, Turner J, van den Heuvel M, van den Heuvel O, van Erp T, van Rooij D, Veltman D, Walter H, Wang Y, Wardlaw J, Whelan C, Wright M, Ye J, for the ENIGMA Consortium. ENIGMA and the individual : Predicting factors that affect the brain in 35 countries worldwide. NeuroImage, 145(Pt B):389-408, 2017.1 DOI: 10.1016/j.neuroimage.2015.11.057
  18. Isomura S, Hashimoto R, Nakamura M, Yamashita F, Jimbo S, Hirano Y, Yamamori H, Fujimoto M, Yasuda Y, Mears R, Onitsuka T. Altered sulcogyral patterns of orbitofrontal cortex in a large cohort of patients with schizophrenia. nature partner journal Schizophrenia, 3(1):3:1-4, 2017.1 DOI:10.1038/s41537-016-0008-y

2016年

  1. Setoyama D, Kato T, Hashimoto R, Kunugi H, Hattori K, Hayakawa K, Sato-Kasai M, Shimokawa N, Kaneko S, Yoshida S, Goto Y, Yasuda Y, Yamamori H, Ohgidani M, Sagata N, Miura D, Kang D, Kanba S. Plasma metabolites predict severity of depression and suicidal ideation in psychiatric patients-A multicenter pilot analysis. PLoS One, 11(12):e0165267, 2016.12 DOI: 10.1371/journal.pone.0165267
  2. Adams H, Hibar D, Chouraki V,Stein J, Nyquist P, Renteria M, Trompet S, Arias-Vasquez A, Seshadri S, Desrivieres S, Beecham A, Jahanshad N, Wittfeld K, van der Lee S, Abramovic L, Alhusaini S, Amin N, Andersson M, Arfanakis K, Aribisala B, Armstrong N, Athanasiu L, Axelsson T, Beiser A, Bernard M, Bis J, Blanken L, Blanton S, Bohlken M, Boks M, Bralten J, Brickman A, Carmichael O, Chakravarty M, Chauhan G, Chen Q, Ching C, Cuellar-Partida G, den Braber A, Doan NT, Ehrlich S, Filippi I, Ge T, Giddaluru S, Goldman A, Gottesman R, Greven C, Grimm O, Griswold M, Guadalupe T, Hass J, Haukvik U, Hilal S, Hofer E, Hoehn D, Holmes A, Hoogman M, Janowitz D, Jia T, Karbalai N, Kasperaviciute D, Kim S, Klein M, Kramer B, Lee P, Liao J, Liewald D, Lopez L, Luciano M, Macare M, Marquand A, Matarin M, Mather K, Mattheisen M, Mazoyer B, McKay D, McWhirter R, Milaneschi Y, Muetzel R, Maniega SM, Nho K, Nugent A, Loohuis LO, Oosterlaan J, Papmeyer M, Pappa I, Pirpamer L, Pudas S, Putz B, Rajan K, Ramasamy A, Richards J, Risacher S, Roiz-Santianez R, Rommelse N, Rose E, Royle N, Rundek T, Samann P, Satizabal C, Schmaal L, Schork A, Shen L, Shin J, Shumskaya E, Smith A, Sprooten E, Strike L, Teumer A, Thomson R, Tordesillas-Gutierrez D, Toro R, Trabzuni D, Vaidya D, Van der Grond J, Van der Meer D, van Donkelaar M, Van Eijk K, van Erp T, Van Rooij D, Walton E, Westlye L, Whelan C, Windham B, Winkler A, Woldehawariat G, Wolf C, Wolfers T, Xu B, Yanek L, Yang J, Zijdenbos A, Zwiers M, Agartz I, Aggarwal N, Almasy L, Ames D, Amouyel P, Andreassen O, Arepalli S, Assareh A, Barral S, Bastin M, Becker J, Becker D, Bennett D, Blangero J, Bokhoven H, Boomsma D, Brodaty H, Brouwer R, Brunner H, Buckner R, Buitelaar J, Bulayeva K, Cahn W, Calhoun V, Cannon D, Cavalleri G, Chen C, Cheng C, Cichon S, Cookson M, Corvin A, Crespo-Facorro B, Curran J, Czisch M, Dale A, Davies G, de Geus E, De Jager P, De Zubicaray G, Delanty N, Depondt C, DeStefano A, Dillman A, Djurovic S, Donohoe G, Drevets W, Duggirala R, Dyer T, Erk S, Espeseth T, Evans D, Fedko I, Fernandez G, Ferrucci L, Fisher S, Fleischman D, Ford I, Foroud T, Fox P, Francks C, Fukunaga M, Gibbs J, Glahn D, Gollub R, Gorin H, Grabe H, Green R, Gruber O, Guelfi M, Hansell N, Hardy J, Hartman C, Hashimoto R, Hegenscheid K, Heinz A, Hellard S, Hernandez D, Heslenfeld D, Ho BC, Hoekstra P, Hoffmann W, Hofman A, Holsboer F, Homuth G, Hosten N, Hottenga J, Hulshoff Pol H, Ikeda M, Ikram MK, Jack C, Jenkinson M, Johnson R, Jonsson E, Jukema JW, Kahn R, Kanai R, Kloszewska I, Knopman D, Kochunov P, Kwok J, Launer L, Lawrie S, Lemaitre H, Liu X, Longo D, Longstreth Jr WT, Lopez O, Lovestone S, Martinez O, Martinot JL, Mattay V, McDonald C, Mcintosh A, McMahon F, McMahon K, Mecocci P, Melle I, Meyer-Lindenberg A, Mohnke S, Montgomery G, Morris D, Mosley T, Muhleisen T, Muller-Myhsok B, Nalls M, Nauck M, Nichols T, Niessen W, Nothen M, Nyberg L, Ohi K, Olvera R, Ophoff R, Pandolfo M, Paus T, Pausova Z, Penninx B, Pike GB, Potkin S, Psaty B, Reppermund S, Rietschel M, Roffman J, RomanczukSeiferth N, Rotter J, Ryten M, Sacco R, Sachdev P, Saykin A, Schmidt R, Schofield P, Sigursson S, Simmons A, Singleton A, Sisodiya S, Smith C, Smoller J, Soininen H, Srikanth V, Steen V, Stott D, Sussmann J, Thalamuthu A, Tiemeier H, Toga A, Traynor B, Troncoso J, Turner J, Tzorio C, Uitterlinden A, Valdes Hernandez M, Van der Brug M, van der Lugt A, van der Wee N, van Duijn C, van Haren N, van't Ent D, Van Tol MJ, Vardarajan B, Veltman D, Vernooij M, Volzke H, Walter H, Wardlaw J, Wassink T, Weale M, Weinberger D,Michael Weiner M, Wen W, Westman E, White T, Wong T, Wright C, Zielke R, Zonderman A, Deary I, DeCarli C, Schmidt H, Martin N, De Craen A, Wright M, Gudnason V, Schumann G, Fornage M, Franke B,Debette S, Medland S, Ikram A, Thompson P. Novel genetic loci underlying human intracranial volume identified through genome-wide association. Nat Neurosci, 19(12):1569-1582, 2016.12 DOI: 10.1038/nn.4398
  3. Onaka Y, Shintani N, Nakazawa T, Knoh T, Ago Y, Matsuda T, Hashimoto R, Ohi K, Hirai H, Nagata KY, Nakamura M, Hayata-Takano A, Nagayasu K, Takuma K, Ogawa A, Baba A, Hashimoto H. Prostaglandin D2 signaling mediated by the CRTH2 receptor is involved in MK-801-induced cognitive dysfunction. Behav Brain Res, 314:77-86, 2016.11 DOI: 10.1016/j.bbr.2016.07.050
  4. Sumiyoshi C, Fujino H, Sumiyoshi T, Yasuda Y, Yamamori H, Ohi K, Fujimoto M, Takeda M, Hashimoto R. Usefulness of the Wechsler Intelligence Scale short form for assessing functional outcomes in patients with schizophrenia. Psychiatry Res, 245:371-378, 2016.11 DOI: 10.1016/j.psychres.2016.08.018
  5. Fujimoto M, *Hashimoto R, Yamamori H, Yasuda Y, Ohi K, Iwatani H, Isaka Y, Takeda M. Clozapine improved the syndrome of inappropriate antidiuretic hormone secretion (SIADH) in a patient with treatment-resistant schizophrenia, Psychiatry Clin Neurosci, 70:469, 2016.10 DOI: 10.1111/pcn.12435
  6. Miyashita M, Watanabe T, Ichikawa T, Toriumi K, Horiuchi Y, Kobori A, Kushima I, Hashimoto R, Fukumoto M, Koike S, Ujike H, Arinami T, Tatebayashi Y, Kasai K, Takeda M, Ozaki N, Okazaki Y, Yoshikawa T, Amano N, Washizuka S, Yamamoto H, Miyata T, Itokawa M, Yamamoto Y, Arai M. The regulation of soluble receptor for AGEs contributes to carbonyl stress in schizophrenia. Biochem Biophys Res Commun, 479(3):447-452, 2016.10 DOI: 10.1016/j.bbrc.2016.09.074
  7. Fujimori K, Tezuka T, Ishiura H, Mitsui J, Doi K, Yoshimura J, Tada H, Matsumoto T, Isoda M, Hashimoto R, Nattori N, Takahashi T, Morishita S, Tsuji S, Akamatsu W, Okano H. Modeling neurological diseases with induced pluripotent cells reprogrammed from immortalized lymphoblastoid cell lines. Mol Brain, 9(1):88, 2016.10 DOI:10.1186/s13041-016-0267-6
  8. Saito T, Ikeda M, Mushiroda T, Ozeki T, Kondo K, Shimasaki A, Kawase K, Hashimoto S, Yamamori H, Yasuda Y, Fujimoto M, Ohi K, Takeda M, Kamatani Y, Numata S, Ohmori T, Ueno S, Makinodan M, Nishihata Y, Kubota M, Kimura T, Kanahara N, Hashimoto N, Fujita K, Nemoto K, Fukao T, Suwa T, Noda T, Yada Y, Takaki M, Kida N, Otsuru T, Nurakami M, Takahashi A, Kubo M, *Hashimoto R, Iwata N. Pharmacogenomic study of clozapine-induced agranulocytosis/granulocytopenia in a Japanese population. Biol Psychiatry, 80:636-642, 2016.10 DOI: 10.1016/j.biopsych.2015.12.006
  9. Okada N, Fukunaga M, Yamashita F, Koshiyama D, Yamamori H, Ohi K, Yasuda Y, Fujimoto M, Watanabe Y, Yahata N, Nemoto K, Hibar D, van Erp T, Fujino H, Isobe M, Isomura S, Natsubori T, Narita H, Hashimoto N, Miyata J, Koike S, Takahashi T, Yamasue H, Matsuo K, Onitsuka T, Iidaka T, Kawasaki Y, Yoshimura R, Watanabe Y, Suzuki M, Turner J, Takeda M, Thompson P, Ozaki N, Kasai K, *Hashimoto R, COCORO. Abnormal asymmetries in subcortical brain volume in schizophrenia. Mol Psychiatry, 21:1460-1466, 2016.10 DOI: 10.1038/mp.2015.209
  10. Ohi K, Kikuchi M, Ikeda M, Yamamori H, Yasuda Y, Fujimoto M, Fujino H, Miura K, Fukunaga M, Nakaya A, Iwata N, *Hashimoto R. Polygenetic Components for Schizophrenia, Bipolar Disorder and Rheumatoid Arthritis Predict Risk of Schizophrenia. Schizophr Res, 175:226-229, 2016.8 DOI: 10.1016/j.schres.2016.04.009
  11. Prosselkov P, Hashimoto R, Polygalov D, Ohi K, Zhang Qi, McHugh T, Takeda M, Itohara S. Cognitive enophenotypes of modern and extinct hominins associated with NTNG gene paralogs. Biomedical Genetics and Genomics, 1(1): 5-13, 2016.4 DOI: 10.15761/BGG.1000103
  12. Matsumura K, Nakazawa T, Nagayasu K, Gotoda-Nishimura N, Kasai A, Hayata-Takano A, Shintani N, Yamamori H, Yasuda Y, Hashimoto R, Hashimoto H. De novo POGZ mutations in sporadic autism disrupt the DNA-binding activity of POGZ. J Mol Psychiatry, 4:1, 2016.4 DOI: 10.1186/s40303-016-0016-x
  13. van Erp T, Hibar D, Rasmussen J, Glahn D, Pearlson G, Andreassen O, Agartz I, Westlye L, Haukvik UK, Dale A, Melle I, Hartberg C, Gruber O, Kramer B, Zilles D, Donohoe G, Kelly S, McDonald C, Morris D, Cannon DM, Corvin A, Machielsen M, Koenders L, de Haan L, Veltman D, Satterthwaite T, Wolf D, Gur RC, Gur RE, Potkin S, Mathalon D, Mueller B, Preda A, Macciardi F, Ehrlich S, Walton E, Hass J, Calhoun V, Bockholt H, Sponheim S, Shoemaker J, van Haren N, Hulshoff Pol H, Ophoff R, Kahn RS, Roiz-Santianez R, Crespo-Facorro B, Wang L, Alpert K, Jonsson E, Dimitrova R, Bois C, Whalley H, McIntosh A, Lawrie S, Hashimoto R, Thompson P, Turner J, for the ENIGMA Schizophrenia Working Group, Subcortical Brain Volume Abnormalities in 2,028 Individuals with Schizophrenia and 2,540 Healthy Controls via the ENIGMA Consortium. Mol Psychiatry, 21(4):547-553, 2016.4 DOI: 10.1038/mp.2015.63
  14. Higashiyama R, Ohnuma T, Takebayashi Y, Hanzawa R, Shibata N, Yamamori H, Yasuda Y, Kushima I, Aleksic B, Kondo K, Ikeda M, Hashimoto R, Iwata N, Ozaki N, Arai H. Association of copy number polymorphisms at the promoter and translated region of COMT with Japanese patients with schizophrenia. Am J Med Genet B Neuropsychiatr Genet, 171(3):447-457, 2016.4 DOI: 10.1002/ajmg.b.32426
  15. Franke B, Stein JL, Ripke S, Anttila V, Hibar DP, van Hulzen KJE, Arias-Vasquez A, Smoller JW, Nichols TE, Neale MC, McIntosh AM, Lee P, McMahon FJ, Meyer-Lindenberg A, Mattheisen M, Andreassen OA, Gruber O, Sachdev PS, Roiz-Santianez R, Saykin AJ, Ehrlich S, Mather KA, Turner JA, Schwarz E, Thalamuthu A, Shugart YY, Ho YY, Martin NG, Wright MJ; Schizophrenia Working Group of the Psychiatric Genomics Consortium; ENIGMA Consortium, O'Donovan MC, Thompson PM, Neale BM, Medland SE, Sullivan PF.Genetic influences on schizophrenia and subcortical brain volumes: large-scale proof of concept. Nat Neurosci, 19(3):420-431, 2016.3 DOI: 10.1038/nn.4228
  16. Hou L, Heilbronner U, Degenhardt F, Adli M, Akiyama K, Akula N, Ardau R, Arias B, Backlund L, Banzato C, Benabarre A, Bengesser S, Bhattacharjee A.K., Biernacka J.M., Birner A, Brichant-Petitjean C, Bui E.T., Cervantes P, Chen G, Chen H, Chillotti C, Cichon S, Clark S.R., Colom F, Cousins D, Cruceanu C, Czerski P.M., Dantas C.R., Dayer A, Etain B, Falkai P, Forstner A.J., Frisen L, Fullerton J.M., Gard S, Garnham J.S., Goes F.S., Grof P, Gruber O, Hashimoto R, Hauser J, Herms S, Hoffmann P, Hofmann A, Jamain S, Jimenez E, Kahn J, Kassem L, Kittel-Schneider S, Kliwicki S, Konig B.B., Kusumi I, Lackner N, Laje G, Landen M, Lavebratt C, Leboyer M, Leckband S.G., Jaramillo C.L., MacQueen G, Manchia M, Martinsson L, Mattheisen M, McCarthy M.J., McElroy S, Mitjans M, Francis M. Mondimo F.M., Monteleone P, Nievergelt C.M., Nothen M.M., Osby U, Ozaki N, Perlis R.H., Pfennig A, Reich-Erkelenz D, Rouleau G.A., Schofield P.R., Schubert K.O., Schweizer B.W., Seemuller F, Severino G, Shekhtman T, Shilling P.D., Shimoda K, Simhandl C, Slaney C.M., Smoller J.W., Squassina A, Stamm T, Stopkova P, Tighe S.K., Tortorella A, Turecki G, Volkert J, Witt S, Wright A, Young L.T., Zandi P.P., Potash J.B., DePaulo J.R., Bauer M, Reininghaus E, Novak T, Aubry J.M., Maj M., Baune B.T., Mitchell P.B., Vieta E, Frye M.A., Rybakowski J.K., Kuo P, Kato T, Grigoroiu-Serbanescu M, Reif A, Zompo M.D., Bellivier F, Schalling M, Wray N.R., Kelsoe J, Alda M, Rietschel M, McMahon F.J., Schulze T.G. Genetic variants associated with response to lithium treatment in bipolar disorder: a genome-wide association study. Lancet, 12;387(10023):1085-93, 2016.3 DOI:/10.1016/S0140-6736(16)00143-4
  17. *Hashimoto R, Nakazawa T, Tsurusaki Y, Yasuda Y, Nagayasu K, Matsumura K, Kawashima H, Yamamori H, Fujimoto M, Ohi K, Umeda-Yano S, Fukunaga M, Fujino H, Kasai A, Hayata-Takano A, Shintani N, Takeda M, Matsumoto N, Hashimoto H. Whole-exome sequencing and neurite outgrowth analysis in autism spectrum disorder. J Hum Genet, 61(3):199-206 , 2016.3 DOI: 10.1038/jhg.2015.141
  18. Yasuda Y, Hashimoto R, Nakae A, Kang H, Ohi K, Yamamori H, Fujimoto M, Hagihira S, Takeda M. Sensory cognitive abnormalities of pain in autism spectrum disorder: a case control study. Ann Gen Psychiatry,15:8, 2016.3 DOI:10.1186/s12991-016-0095-1
  19. Fujino H, Sumiyoshi C, Sumiyoshi T, Ysuda Y, Yamamori H, Ohi K, Fujimoto M, *Hashimoto R, Takeda M, Imura O. Predicting employment status and subjective quality of life in patients with schizophrenia. Schizophrenia Research: Cognition, 3:20-25, 2016. 3 DOI:10.1016/j.scog.2015.10.005
  20. Kamada Y, Hashimoto R, Yamamori H, Yasuda Y, Takehara T, Fujita Y, Hashimoto K, Miyoshi E. Impact of plasma transaminase levels on the peripheral blood glutamate levels and memory functions in healthy subjects. BBA Clin, 5:101-107, 2016.2 DOI:10.1016/j.bbacli.2016.02.004
  21. *Nakazawa T, *Hashimoto R, Sakoori K, Sugaya Y, Tanimura A, Hashimotodani Y, Ohi K, Yamamori H, Yasuda Y, Umeda-Yano S, Kiyama Y, Konno K, Inoue T, Yokoyama K, Inoue T, Numata S, Ohnuma T, Iwata N, Ozaki N, Hashimoto H, Watanabe M, Manabe T, Yamamoto T, Takeda M, *Kano M. Emerging Roles of ARHGAP33 in Intracellular Trafficking of TrkB and Pathophysiology of Neuropsychiatric Disorders. Nat Commun, 7:10594, 2016.2 DOI: 10.1038/ncomms10594
  22. Gould T.D., Hashimoto R, Schulze T.G. Going longitudinal in biological psychiatric research: all things considered. Neurosci Res, 102(2016):1-3, 2016.1 DOI:10.1016/j.neures.2015.12.012
  23. Kato TA, Hashimoto R, Hayakawa K, Kubo H, Watabe M, Teo AR, Kanba S. Multidimensional anatomy of 'modern type depression' in Japan: A proposal for a different diagnostic approach to depression beyond the DSM-5. Psychiatry Clin Neurosci, 70(1):7-23, 2016.1 DOI: 10.1111/pcn.12360
  24. Yamamori H, Ishima T, Yasuda Y, Fujimoto M, Kudo N, Ohi K, Hashimoto K, Takeda M, Hashimoto R. Assessment of a multi-assay biological diagnostic test for mood disorders in a Japanesepopulation. Neurosci Lett, 612:167-171, 2015.12 DOI: 10.1016/j.neulet.2015.12.019

2015年

  1. Nishizawa D, Kasai S, Hasegawa J, Sato N, Yamada H, Tanioka F, Nagashima M, Katoh R, Satoh Y, Tagami M, Ujike H, Ozaki N, Inada T, Iwata N, Sora I, Iyo M, Yamada M, Kondo N, Won MJ, Naruse N, Uehara-Aoyama K, Itokawa M, Ohi K, Hashimoto R, Tanisawa K, Arai T, Mori S, Sawabe M, Naka-Mieno M, Yamada Y, Yamada M, Sato N, Muramatsu M, Tanaka M, Irukayama-Tomobe Y, Saito Y, Sakurai T, Hayashida M, Sugimura H, Ikeda K. Associations between the orexin (hypocretin) receptor 2 gene polymorphism Val308Ile and nicotine dependence in genome-wide and subsequent association studies. Molecular Brain, 20;8(1):50, 2015.8 DOI: 10.1186/s13041-015-0142-x
  2. Ohi K, *Hashimoto R, Ikeda M, Yamamori H, Yasuda Y, Fujimoto M, Umeda-Yano S, Fukunaga M, Fujino H, Watanabe Y, Iwase M, Kazui H, Iwata N, Weinberger DR, Takeda M. Glutamate Networks Implicate Cognitive Impairments in Schizophrenia: Genome-Wide Association Studies of 52 Cognitive Phenotypes. Schizophrenia Bulletin, 41(4):909-18, 2015.7 DOI: 10.1093/schbul/sbu171
  3. Shirai Y, Fujita Y, Hashimoto R, Ohi K, Yamamori H, Yasuda Y, Ishima T, Suganuma H, Ushida Y, Takeda M, Hashimoto K. Dietary intake of sulforaphane-rich broccoli sprout extracts during juvenile and adolescence can prevent phencyclidine-induced cognitive deficits at adulthood. PLoS One, 24;10(6):e0127244, 2015.6 DOI: 10.1371/journal.pone.0127244
  4. Inoshita M, Numata S, Tajima A, Kinoshita M, Umehara H, Yamamori H, Hashimoto R, Imoto I, Ohmori T. Sex differences of leukocytes DNA methylation adjusted for estimated cellularproportions. Biology of Sex Differences, 25;6:11, 2015.6 DOI: 10.1186/s13293-015-0029-7
  5. Shibasaki Y, Hayata-Takano A, Hazama K, Nakazawa T, Shintani N, Kasai A, Nagayasu K, Hashimoto R, Tanida M, Katayama T, Matsuzaki S, Yamada K, Taniike M, Onaka Y, Ago Y, Wschek J, Koves K, Reglodi D, Tamas A, Matsuda T, Baba A, Hashimoto H. Atomoxetine reverses locomotor hyperactivity, impaired novel object recognition, and prepulse inhibition impairment in mice lacking pituitary adenylate cyclase-activating polypeptide (PACAP). Neuroscience, 297:95-104, 2015.6 DOI: 10.1016/j.neuroscience.2015.03.062
  6. Higashi S, Katagi K, Shintani N, Ikeda K, Suimoto Y, Tsuchiya S, Inoue N Tanaka S, Koumoto M, Kasai A, Nakazawa T, Hayata-Takano A, Hamagami K, Tomimoto S, Yoshida T, Ohkubo T, Nagayasu K, Ago Y, Onaka Y, Hashimoto R, Ichikawa A, Baba A, Hashimto H. p13 overexpression in pancreatic β-cells ameliorates type 2 diabetes in high-fat-fed mice. Biochemical and Biophysical Research Communications, 461:612-617, 2015.6 DOI: 10.1016/j.bbrc.2015.04.074
  7. Onaka Y, Shintani N, Nakazawa T, Haba R, Ago Y, Wang H, Kanoh T, Hayata-Takano A, Hirai H, Nagata K, Nakamura M, Hashimoto R, Matsuda T, Waschek J.A., Kasai A, Nagayasu K, Baba A, Hashimoto H. CRTH2, a prostaglandin D2 receptor, mediates depression-related behavior in mice. Behavioural Brain Research, 284:131-137, 2015.5 DOI:10.1016/j.bbr.2015.02.013
  8. Ohi K, Ursini G, Li M, Shin J.H.,Ye T, Chen Q, Tao R, Kleinman JE., Hyde TM., Hashimoto R, Weinberger DR. DEGS2 polymorphism associated with cognition in schizophrenia is associated with gene expression in brain. Translational Psychiatry, 14;5:e550, 2015.4 DOI: 10.1038/tp.2015.45
  9. Hibar DP, Stein JL, Renteria ME, Arias-Vasquez A, Desrivieres S, Jahanshad N, Toro R, Wittfeld K, Abramovic L, Andersson M, Aribisala B, Armstrong NJ, Bernard M, Bohlken M, Boks MP, Bralten J, Brown AA, Chakravarty M, Chen Q, Ching C, Cuellar-Partida G, Den Braber A, Giddaluru S, Goldman AL, Grimm O, Guadalupe T,Hass J, Woldehawariat G, Holmes AJ, Hoogman M, Janowitz D, Jia T, Kim S,Klein M, Kraemer B, Lee PH, Loohuis L.O., Luciano M, Macare C, Mather KA, Mattheisen M, Milaneschi Y, Nho K, Papmeyer M, Ramasamy A, Risacher SL, Roiz-Santianez R, Rose EJ, Salami A, Samann P, Schmaal L, Schork AJ, Shin J, Strike LT, Teumer A, Van Donkelaar MJ, Van Eijk K, Walters RK, Westlye LT, Whelan CD, Winkler AM, Zwiers MP, Alhusaini S, Athanasiu L, Ehrlich S, Hakobjan MH, Hartberg CB, Haukvik U, Heister A.H, Hohn D, Kasperaviciute D, Liewald D C.M, Lopez LM, Makkinje R, Matarin M, Naber M, McKay DR, Needham M, Nugent AC, Putz B, Royle NA, Shen L, Sprooten E, Trabzuni D, Van der Marel S, Van Hulzen K, Walton E, Wolf C, Almasy L, Ames D, Arepalli, Assareh A, Bastin M, Brodaty H, Bulayeva K, Carless M, Cichon S, Corvin A, Curran J, Czisch M, De Zubicaray G, Dillman A, Duggirala R, Dyer T, Erk S, Fedko IF, Ferrucci L, Foroud TM, Fox PP, Fukunaga M, Gibbs R, Goring H, Green R, Guelfi M, Hansell N, Hartman CA, Hegenscheid K, Heinz A, Hernandez DF, Hesenfeld DJ, Hoekstra PJ, Holsboer F, Homuth G, Hottenga JJ, Ikeda M, Jack Jr CR, Jenkinson M, Johnson R, Kanai R, Keil M, Kent Jr JW, Kochunov P, Kwok JB, Lawrie SM, Liu X, Longo D, McMahon K, Meisenzahl E, Melle I, Mohnke S, Montgomery G, Mostert J, Muhleisen T, Nalls M, Nichols TE, Nilsson LG, Nothen M, Ohi K, Olvera R, Perez-Iglesias R, Pike G.B., Potkin S, Reinvang I, Reppermund S, Rietschel M, Romanczuk-Seiferth N, Rosen G, Rujescu D, Schnell K, Schofield P, Smith C, Steen V, Sussmann J, Thalamuthu A, Toga A, Traynor B, Troncoso J, Turner J, Hernandez MC, Van 't Ent D, Van der Brug M, Van der Wee N, Van Tol M.J, Veltman D, Wassink T, Westman E, Zielke H, Zonderman A, Ashbrook D, Hager R, Lu L, McMahon F, Morris D, Williams R, Brunner H, Buckner R, Buitelaar J, Cahn W, Calhoun VD, Cavalleri G, Crespo-Facorro B, Dale A, Davies G, Delanty N, Depondt C, Djurovic S, Drevets W, Espeseth T, Gollub R, Ho BC, Hoffmann W, Hosten N, Kahn R, Le Hellard S.L., Meyer-Lindenberg A, Muller-Myhsok B, Nauck M, Nyberg L, Pandolfo M, Penninx B, Roffman J, Sisodiya S, Smoller J, Van Bokhoven H, Van Haren N, Volzke H, Walter H, Weiner M, Wen W, White T, Agartz I, Andreassen O, Blangero J, Boomsma D, Brouwer R, Cannon D, Cookson M, De Geus E, Deary I, Donohoe G, Fernandez G, Fisher S, Francks C, Glahn D, Grabe H, Gruber O, Hardy J, Hashimoto R, Hulshoff Pol H, Jonsson E, Kloszewska I, Lovestone S, Mattay V, Mecocci P, McDonald C, McIntosh A, Ophoff R, Pausova Z, Paus T, Ryten M, Sachdev P, Saykin A, Simmons A, Singleton A, Soininen H, Wardlaw J, Weale M, Weinberger DR, Adams H, Launer L, Seiler S, Schmidt R, Chauhan G, Satizabal C, Becker J, Yanek L, Van der Lee S, Ebling M, Fischl B, Longstreth W, Greve D, Schmidt H, Nyquist P, Vinke L, Van Duijn C, Luting X, Mazoyer B, Bis J, Gudnason V, Seshadri S, Ikram M, the ADNI, the CHARGE, the EPIGEN, the IMAGEN, the SYS, Martin N, Wright M, Schumann M, Franke B, Thompson P, Medland S.E.Common genetic variants influence human subcortical brain structures. Nature, 9;520(7546):224-9, 2015.4 DOI: 10.1038/nature14101
  10. Hashimoto R, Ohi K, Yamamori H, Yasuda Y, Fujimoto M, Umeda-Yano S, Watanabe Y, Fukunaga M, Takeda M. Imaging genetics and psychiatric disorders. Curr Mol Med, 15(2):168-75, 2015.4 DOI: 10.2174/1566524015666150303104159
  11. Uno K, Nishizawa D, Seo S, Takayama K, Matsumura S, Sakai N, Ohi K, Nabeshima T, Hashimoto R, Ozaki N, Hasegawa J, Sato N, Tanioka F, Sugimura H, Fukuda K, Higuchi S, Ujike H, Inada T, Iwata N, Sora I, Iyo M, Kondo N, Won MJ, Naruse N, Uehara-Aoyama K, Itokawa M, Yamada M, Ikeda K, Miyamoto Y, Nitta A. The Piccolo Intronic Single Nucleotide Polymorphism rs13438494 Regulates Dopamine and Serotonin Uptake and Shows Associations with Dependence-like Behavior in Genomic Association Study. Curr Mol Med, 15(3):265-74, 2015.3 DOI: 10.2174/1566524015666150330145722
  12. Matuura Y, Fujino H, Hashimoto R, Yasuda Y, Yamamori H, Ohi K, Takeda T, Imura O. Standing postural instability in patients with schizophrenia: Relationships with psychiatric symptoms, anxiety, and the use of neuroleptic medications. Gait & Posture, 41:847-851, 2015.3 DOI: 10.1016/j.gaitpost.2015.03.006
  13. Ogata K, Shintani N, Hayata-Takano A, Kamo T, Higashi S, Seiriki K, Momosaki H, Vaudry D, Vaudry H, Galas L, Kasai A, Nagayasu K, Nakazawa T, Hashimoto R, Ago Y, Matsuda T, Baba A, Hashimoto H. PACAP enhances axon and neurite outgrowth in cultured hippocampal neurons to a comparable extent as BDNF. PloS One, 25;10(3):e0120526, 2015.3 DOI: 10.1371/journal.pone.0120526
  14. Matsuno H, Ohi K, *Hashimoto R, Yamamori H, Yasuda Y, Fujimoto M, Yano-Umeda S, Saneyoshi T, Takeda M, Hayashi Y. A naturally occurring null variant of the NMDA type glutamate receptor NR3B subunit is a risk factor of schizophrenia. PLoS One, 13;10(3):e0116319, 2015.3 DOI: 10.1371/journal.pone.0116319
  15. Schulze W, Hayata-Takano A, Kamo T, Nakazawa T, Nagayasu K, Kasai A, Seiriki K, Shintani N, Ago Y, Farfan C, Hashimoto R, Baba A, Hashimoto H. Simultaneous neuron- and astrocyte-specific fluorescent marking. Biochemical and Biophysical Research Communications, 459:81-86, 2015.3 DOI: 10.1016/j.bbrc.2015.02.073
  16. Yamasaki A, Kasai A, Toi A, Kurita M, Kimoto S, Hayata-Takano A, Nakazawa T, Nagayasu K, Shintani N, Hashimoto R, Ito A, Meltzer HY, Ago Y, Waschek JA, Onaka Y, matsuda T, Baba A, Hashimoto H. Identification of the role of BMP and TGF-β signaling in the trajectory of serotonergic differentiation in a rapid assay in mouse embryonic stem cells in vitro. Journal of Neurochemistry, 132(4):418-28, 2015.2 DOI: 10.1111/jnc.12999
  17. Ikeda M, Yoshimura R, Hashimoto R, Kondo K, Saito T, Shimasaki A, Ohi K, Tochigi M, Kawamura Y, Nishida N, Miyagawa T, Sasaki T, Tokunaga K, Kasai K, Takeda M, Nakamura J, Ozaki N, Iwata N. Genetic overlap between antipsychotic response and susceptibility to schizophrenia. Journal of Clinical Psychopharmacology, 35(1):85-8, 2015.2 DOI: 10.1097/JCP.0000000000000268

2014年

  1. Miura K, *Hashimoto R, Fujimoto M, Yamamori H, Yasuda Y, Ohi K, Umeda-Yano S, Fukunaga M, Iwase M, Takeda M. An integrated eye movement score as a neurophysiological marker of schizophrenia. Schizophrenia Research, 160(1-3):228-9, 2014.12 DOI: 10.1016/j.schres.2014.10.023
  2. Li M, Ohi K, Chen C, He Q, Lu JW, Chen C. Luo XJ, Dong Q, Hashimoto R, Su B. Failure of replicating the association between hippocampal volume and 3 single-nucleotide polymorphisms identified from theEuropean genome-wide association study in Asian populations. Neurobiology of Aging, 35(12):2883e.1-2, 2014.12, DOI: 10.1016/j.neurobiolaging.2014.07.015
  3. Kinoshita M, Numata S, Tajima A, Ohi K, Hashimoto R, Shimodera S, Imoto I, Takeda M, Ohmori T. Aberrant DNA methylation of blood in schizophrenia by adjusting for estimated cellular proportions. NeuroMolecular Medicine, 16:697-703, 2014. 12 DOI: 10.1007/s12017-014-8319-5
  4. Shintani N, Onaka Y, *Hashimoto R, Takamura H, Nagata T, Umeda-Yano S, Mouri A, Mamiya T, Haba R, Matsuzaki S, Katayama T, Yamamori H, Nakazawa T, Nagayasu K, Ago Y, Yagasaki Y, Nabeshima T, Takeda M, Hashimoto H. Behavioral characterization of mice overexpressing human dysbindin-1. Molecular Brain, 9;7(1):74, 2014.10 DOI:10.1186/s13041-014-0074-x
  5. *Hashimoto R, Ikeda M, Yamashita F, Ohi K, Yamamori H, Yasuda Y, Fujimoto M, Fukunaga M, Nemoto K, Takahashi T, Ochigi M, Onitsuka T, Yamasue H, Matsuo K, Iidaka T, Iwata N, Suzuki M, Takeda M, Kasai K, Ozaki N. Common variants at 1p36 are associated with superior frontal gyrus volume. Translational Psychiatry, 4:e472, 2014. 10 DOI:10.1038/tp.2014.110
  6. Miki K, Hashimoto R, Shi K, Yukioka M, Opioid therapy for knee osteoarthritis and postoperative persistent pain after knee arthroplasty. Rheumatology, 53(10):1723-4. 2014.10 DOI:10.1093/rheumatology/keu309
  7. Yamamori H, *Hashimoto R, Fujita Y, Numata S, Yasuda Y, Fujimoto M, Ohi K, Umeda-Yano S, Ito A, Ohmori T, Hashimoto K, Takeda M. Changes in plasma D-serine, L-serine, and glycine levels in treatment-resistant schizophrenia before and after clozapine treatment. Neurosci Lett, 582:93-8, 2014.10 DOI: 10.1016/j.neulet.2014.08.052
  8. Nishi A, Numata S, Tajima A, Kinoshita M, Kikuchi K, Shimodera S, Tomotake M, Ohi K, Hashimoto R, Imoto I, Takeda M, Ohmori T. Meta-analyses of blood homocysteine levels for gender and genetic association studies of the MTHFR C677T polymorphism in schizophrenia, Schizophrenia Bulletin, 40(5):1154-63, 2014.9 DOI: 10.1093/schbul/sbt154
  9. Ohi K, *Hashimoto R, Ikeda M, Yamashita F, Fukunaga M, Nemoto K, Ohnishi T, Yamamori H, Yasuda Y, Fujimoto M, Umeda-Yano S, Watanabe Y, Iwata N, Weinberger DR, Takeda M. Genetic risk variants of schizophrenia associated with left superior temporal gyrus volume. Cortex, 58C:23-26, 2014.9 DOI: 10.1016/j.cortex.2014.05.011
  10. Yasuda Y, *Hashimoto R, Fukai R, Okamoto N, Hirai Y, Yamamori H, Fujimoto M, Ohi K, Taniike M, Mohri I, Nakashima M, Tsurusaki Y, Saitsu H, Matsumoto N, Miyake N, Takeda M. Duplication of the NPHP1 gene in patients with autism spectrum disorder and normal intellectual ability: a case series. Annals of General Psychiatry, 13:22. 2014.8 DOI: 10.1186/s12991-014-0022-2
  11. Watanabe Y, Tanaka H, Tsukabe A, Kunitomi Y, Nishizawa M, Hashimoto R, Yamamori H, Fujimoto M, Fukunaga M, Tomiyama N. Neuromelanin magnetic resonance imaging reveals increased dopaminergic neuron activity in the substantia nigra of patients with schizophrenia. PLos One, 11:9(8):e104619, 2014.8 DOI: 10.1371/journal.pone.0104619
  12. Iwata R, Ohi K, Kobayashi Y, Masuda A, Masuda A, Iwama M, Yasuda Y, Yamamori H, Tanaka M, Hashimoto R, Itohara S, Iwasato T. RacGAP α2-chimaerin function in development adjusts cognitive ability in adulthood. Cell Report, 8(5):1257-64, 2014.8 DOI: 10.1016/j.celrep.2014.07.047
  13. Fujino H, Sumiyoshi C, Sumiyoshi T, Yasuda Y, Yamamori H, Ohi K, Fujimoto M, Umeda-Yano S, Higuchi A, Hibi Y, Matsuura Y, *Hashimoto R, Takeda M, Imura O. Performance on the Wechsler Adult Intelligence Scale-III in Japanese patients with schizophrenia. Psychiatry and Clinical Neurosciences, 68(7):534-541, 2014.7 DOI: 10.1111/pcn.12165
  14. Yasuda Y, *Hashimoto R, Ohi K, Yamamori H, Fujimoto M, Umeda-Yano S, Fujino H, Takeda M. Cognitive inflexibility in Japanese adolescents and adults with autism spectrum disorders. Workd J Psychiatr, 22;4(2):42-48, 2014.6 DOI: 10.5498/wjp.v4.i2.42
  15. Nishizawa D, Ohi K, *Hashimoto R, Yamamori H, Yasuda Y, Fujimoto M, Umeda-Yano S, Takeda M, Ikeda K. Association between genetic polymorphism rs2952768, close to the METTL21A and CREB1 genes, and intellectual ability in healthy subjects. Journal of Addiction Research & Therapy, 5(2):1000178, 2014.6 DOI: 10.4172/2155-6105.1000178
  16. Horiguchi M, Ohi K, *Hashimoto R, Hao Q, Yasuda Y, Yamamori H, Fujimoto M, Umeda-Yano S, Takeda M, Ichinose H. A functional polymorphism (C-824T) of the tyrosine hydroxylase gene affects intelligence quotient in schizophrenia. Psychiatry and Clinical Neurosciences, 68(6):456-62, 2014.6 DOI: 10.1111/pcn.12157
  17. Dickinson D, Straub RE, Trampush JW, Gao Y, Feng N, Xie B, Shin JH, Lim HK, Ursini G, Bigos KL, Kolachana B, Hashimoto R, Takeda M, Baum GL, Rujescu D, Callicott JH, Hyde TM, Berman KF, Kleinman JE, Weinberger DR. Differential Effects of Common Variants in SCN2A on General Cognitive Ability, Brain Physiology, and messenger RNA Expression in Schizophrenia Cases and Control Individuals. JAMA Psychiatry. 1;71(6):647-56, 2014.6 DOI: 10.1001/jamapsychiatry.2014.157
  18. Ohgidani M, Kato T.A., Setoyama D, Sagata N, Hashimoto R, Shigenobu K, Yoshida T, Hayakawa K, Shimokawa N, Miura D, Utsumi H, Kanba S. Direct induction of ramified microglia-like cells from human monocytes: Dynamic microglial dysfunction in Nasu-Hakola disease. Scientific Reports 14;4:4957, 2014.5 DOI: 10.1038/srep04957
  19. Umeda-Yano S, *Hashimoto R, Yamamori H, Wickertd CS, Yasuda Y, Ohi K, Fujimoto M, Ito A, Takeda M. Expression analysis of the genes identified in GWAS of the postmortem brain tissues from patients with schizophrenia. Neurosci Lett, 568:12-16, 2014.3 DOI: 10.1016/j.neulet.2014.03.031
  20. Yasuda Y, *Hashimoto R, Ohi K, Yamamori H, Fujimoto M, Umeda-Yano S, Fujino H, Horiguchi M, Takeda M, Ichinose H. A functional polymorphism of the GTP cyclohydrolase I gene predicts attention performance. Neurosci Lett, 566:46-49, 2014.3 DOI: 10.1016/j.neulet.2014.02.019
  21. Fukumoto M, *Hashimoto R, Ohi K, Yasuda Y, Yamamori H, Umeda-Yano S, Iwase M, Kazui H, Takeda M. Relation between remission status and attention in patients withn schizophrenia. Psychiatry and Clinical Neurosciences, 68(3):234-41, 2014.3 DOI: 10.1111/pcn.12119
  22. Toriumi K, Kondo M, Nagai T, Hashimoto R, Ohi K, Song Z, Tanaka J, Mouri A, Koseki T, Yamamori H, Furukawa-Hibi Y, Mamiya T, Fukushima T, Takeda M, Nitta A, Yamada K, Nabeshima T. Deletion of SHATI/NAT8L increases dopamine D1 receptor on the cell surface in the nucleus accumbens, accelerating methamphetamine dependence. Int J Neuropsychopharmacol, 17:443-453, 2014.3 DOI: 10.1017/S1461145713001302
  23. Morihara T, Hayashi N, Yokokoji M, Akatsu H, Silvermama M, Kimura N, Satoa M, Saito Y, Suzuki T, Yanagida K, Kodama T, Tanaka T, Okochi M, Tagami , Kazui H, Kudo T, Hashimoto R, Itoh N, Nishitomi K, Kabata-Yamagichi Y, Tsunoda T, Takamura H, Katayama T, Kimura R, Kamino K, Hashizume Y, Takeda M. Transcriptome analysis of distinct mouse strains reveals kinesin light chain-1 splicing as an amyloid beta accumulation modifier. Proc. Natl. Acad. Sci., 18;111(7):2638-43, 2014.2 DOI: 10.1073/pnas.1307345111
  24. Haba R, Shintani N, Onaka Y, Kanoh T, Wang H, Takenaga R, Hayata A, Hirai H, Nagata K, Nakamura M, Kasai A, Hashimoto R, Nagayasu K, Nakazawa T, Hashimoto H, Baba A. Central CRTH2, a second prostaglandin D2 receptor, mediates emotional impairment in the lipopolysaccharide and tumor-induced sickness behavior model. The Journal of Neuroscience, 12;34(7):2514-23, 2014.2 DOI: 10.1523/JNEUROSCI.1407-13.2014
  25. Hazama K, Hayata-Takano A, Uetsuki K, Kasai A, Encho N, Shintani N, Nagayasu K, Hashimoto R, Reglodi D, Miyakawa T, Nakazawa T, Baba A, Hashimoto H. Increased behavioral and neuronal responses to a hallucinogenic drug in PACAP heterozygous mutant mice. PLoS One, 20;9(2):e89153, 2014.2 DOI: 10.1371/journal.pone.0089153
  26. Miyashita M, Arai M, Yuzawa H, Ichikawa T, Nohara I, Arai M, Obata N, Toriumi K, Kobori A, Niizato K, Ooshima K, Kushima I, Hashimoto R, Fukumoto M, Koike S, Toyota T, Ujike H, Arinami T, Kasai K, Takeda M, Ozaki N, Okazaki Y, Yoshikawa T, Amano N, Miyata T, Itokawa M. Replication of enhanced carbonyl stress in a subpopulation of schizophrenia. Psychiatry and Clinical Neurosciences, 68(1):83-4, 2014.1 DOI: 10.1111/pcn.12081
  27. Nakai K, Nakae A, Hashimoto R, Mashimo T, Hosokawa K. Antinociceptive effects of mirtazapine, pregabalin, and gabapentin after chronic constriction injury of the infraorbital nerve in rats. J Oral Facial Pain Headache. 2014 Winter;28(1):61-7.2014.1 DOI: 10.11607/jop.1105

2013年

  1. Watanabe Y, Iijima Y, Egawa J, Nunokawa A, Kaneko N, Arinami T, Ujike H, Inada T, Iwata N, Kunugi H, Itokawa M, Sasaki T, Ozaki N, Hashimoto R, Shibuya M, Igeta H, Someya T. Replication in a Japanese population that a MIR30E gene variation is associated with schizophrenia. Schizophr Res, 150(2-3):596-7, 2013.11 DOI: 10.1016/j.schres.2013.08.028
  2. Yamamori H, *Hashimoto R, Ishima T, Kishi F, Yasuda Y, Ohi K, Fujimoto M, Umeda-Yano S, Ito A, Hashimoto K, Takeda M. Plasma levels of mature brain-derived neurotrophic factor (BDNF) and matrix metalloproteinase-9 (MMP-9) in treatment-resistant schizophrenia treated with clozapine. Neurosci Lett, 556(2013):37-41, 2013.11 DOI: 10.1016/j.neulet.2013.09.059
  3. Ohi K, *Hashimoto R, Yasuda Y, Fukumoto M, Yamamori H, Umeda-Yano S, Fujimoto M, Iwase M, Kazui H, Takeda M. Influence of the NRGN gene on intellectual ability in schizophrenia. Journal of Human Genetics, 58(10):700-5, 2013.10 DOI: 10.1038/jhg.2013.82
  4. Kanazawa T, Ikeda M, Glatt S.J, Tsutsumi A, Kikuyama H, Kawamura Y, Nishida N, Miyagawa T, Hashimoto R, Takeda M, Sasaki T, Tokunaga K, Koh J, Iwata N, Yoneda H. Genome-Wide Association Study of Atypical Psychosis. Am J Med Genet B Neuropsychiatry Genet, 162(7):679-86, 2013.10 DOI: 10.1002/ajmg.b.32164
  5. Ohi K, *Hashimoto R, Yamamori H, Yasuda Y, Fujimoto M, Umeda-Yano S, Fukunaga M, Watanabe Y, Iwase M, Kazui H, Takeda M. The impact of the genome-wide supported variant in the cyclin M2 gene on gray matter morphology in schizophrenia. Behavioral and Brain Functions, 9(1):40, 2013.10 DOI: 10.1186/1744-9081-9-40
  6. Seo S, Takayama K, Uno K, Ohi K, Hashimoto R, Nishizawa D, Ikeda K, Miyamoto y, Ozaki N, Nabeshima T, Nitta A. Functional analysis of deep intronic SNP rs13438494 in intron 24 of PCLO gene. PLoS One, 8(10): e76960, 2013.10 DOI: 10.1371/journal.pone.0076960
  7. Ohi K, *Hashimoto R, Yamamori H, Yasuda Y, Fujimoto M, Nakatani N, Kamino K, Takeda M. How to diagnose the 22q11.2 deletion syndrome in patients with schizophrenia: a case report. Annals of General Psychiatry, 12(1):29, 2013.9 DOI: 10.1186/1744-859X-12-29
  8. Ikeda M, Okahisa Y, Aleksic B, Won M, Kondo N, Naruse N, Aoyama-Uehara K, Sora I, Iyo M, Hashimoto R, Kawamura Y, Ninishida N, Miiyagawa T, Takeda M, Sasaki T, Tokunaga K, Ozaki N, Ujike H, Iwata N. Evidence for shared genetic risk between methamphetamine-induced psychosis and schizophrenia. Neuropsychopharmacology, 38(10):1864-70, 2013.9 DOI: 10.1038/npp.2013.94
  9. Kitaichi Y, *Hashimoto R, Inoue T, Abekawa T, Kakuta A, Hattori S, Koyama T. Abnormalities in extracellular glycine and glutamate levels in the striatum of sandy mice. Acta Neuropsychiatrica, 4:215-20, 2013. 8 DOI: 10.1111/acn.12018
  10. Furukawa M, Tochigi M, Otowa T, Arinami T, Inada T, Ujike H, Watanabe Y, Iwata N , Itokawa M, Kunugi H, Hashimoto R, Ozaki N, Kakiuchi C, Kasai K, Sasaki T, An association analysis of the cardiomyopathy-associated 5(CMYA5) gene with schizophrenia in a Japanese population. Psychiatr Genet, 23(4):179-180, 2013.8 DOI: 10.1097/YPG.0b013e328360c8be
  11. *Hashimoto R, Ikeda M, Ohi K, Yasuda Y, Yamamori H, Fukumoto M, Umeda-Yano S, Dickinson D, Aleksic B, Iwase M, Kazui H, Ozaki N, Weinberger DR, Iwata N, Takeda M. Genome-wide association study of cognitive decline in schizophrenia. Am J Psychiatry, 170(6):683-684, 2013.6 DOI: 10.1176/appi.ajp.2013.12091228
  12. Manchia M, Adli M, Akula N, Ardau R, Aubry J.M., Backlund L, Banzato C, Baune B, Bellivier F, Bengeser S, Biernacka J, Brichant-Petitjean C, Bui E, Calkin C, Cheng A, Chillotti C, Cichon S, Clark S, Czerski P, Dantas C, Zompo M, DePaulo J, Detera-Wadleigh S, Etain B, Falkai P, Frisen L, Frye M, Fullerton J, Gard S, Garnham J, Goes F, Grof P, Gruber O, Hashimoto R, Hauser J, Heilbronner U, Hobann R, Hou L, Jamain S, Kahn J, Kassem L, Kato T, Kelsoe J, Kittel-Schneider S, Kliwicki S, Kuo P, Kusumi I, Laje G, Lavebratt C, Leboyer M, Leckband S, Jaaramillo C, Maj M, Malafosse A, Martinsson L, Masui T, Mitchell P, Mondimore F, Monteleone P, Nallet A, Neuner M, Novak T, O'Donovan C, Osby U, Ozaki N, Perlis R, Pfennig A, Potash J, Reich-Erkelenz D, Reif A, Reininghaus E, Richardson S, Rouleau G, Rybakowski J, Schalling M, Schofield P, Schubert O, Schweizer B, Seemuller F, Grigoroiu-Serbanescu M, Severino G, Seymour L, Slaney C, Smoller J, Squassina A, Stamm T, Steele J, Stopkova P, Tighe S, Tortorella A, Turecki G, Wray N, Wright A, Zandi P, Zilles D, Bauer M, Rietschel M, McMahon F, Schulze T, Alda M. Assessment of Response to Lithium maintenance Treatment in Bipolar Disorder: A Consortium on Lithium Genetics (ConLiGen) Report, PLoS One, 8(6): e65636, 2013.6 DOI: 10.1371/journal.pone.0065636
  13. Aleksic B., Kushima I, Hashimoto R, Ohi K, Ikeda M, Yoshimi A, Nakamura Y, Ito Y, Okochi T, Fukuo Y, Yasuda Y, Fukumoto M, Yamamori H, Ujike H, Suzuki M, Inada T, Takeda M, Kaibuchi K, Iwata N, Ozaki N. Analysis of the VAV3 as candidate gene for schizophrenia: evidences from voxel based morphometry and mutation screening. Schizophrenia Bulletin. 39(3):720-8, 2013.5 DOI: 10.1093/schbul/sbs038
  14. Umeda-Yano S, *Hashimoto R, Yamamori H, Okada T, Yasuda Y, Ohi K, Fukumoto M, Ito A, Takeda M. The regulation of gene expression involved in TGF-β signaling by ZNF804A, a risk gene for schizophrenia. Schizophr Res, 146(1-3):273-8, 2013.5 DOI: 10.1093/schbul/sbs038
  15. Ohi K, *Hashimoto R, Yasuda Y, Fukumoto M, Nemoto K, Ohnishi T, Yamamori H, Takahashi H, Iike N, Kamino K, Yoshida T, Azechi M, Ikezawa K, Tanimukai H, Tagami S, Morihara T, Okochi M, Tanaka T, Kudo T, Iwase M, Kazui H, Takeda M. The AKT1 gene is associated with attention and brain morphology in schizophrenia. World J Biol Psychiatry. 14(2):100-13, 2013.3 DOI: 10.3109/15622975.2011.591826
  16. *Hashimoto R, Ohi K, Yasuda Y, Fukumoto M, Yamamori H, Kamino K, Morihara T, Iwase M, Kazui H, Takeda M. The KCNH2 gene is associated with neurocognition and the risk of schizophrenia. World J Biol Psychiatry. 14(2):114-20, 2013.3 DOI: 10.3109/15622975.2011.604350

2012年

  1. Ota M, Sato N, Ishikawa M, Hori H, Sasayama D, Hattori K, Teraishi T, Obu S, Nakata Y, Nemoto K, Moriguchi Y, Hashimoto R, Kunugi H. Discrimination of schizophrenic females from healthy women using multiple structural brain measures obtained with voxel-based morphometry. Psychiatry and Clinical Neurosciences, 66(7):611-7, 2012.12 DOI: 10.1111/j.1440-1819.2012.02397.x
  2. Kinoshita M, Numata S, Tajima A, Ohi K, Hashimoto R, Shimodera S, Imoto I, Itakura M, Takeda M, Ohmori T. Meta-analysis of association studies between DISC1 missense variants and schizophrenia in Japanese population. Schizophr Res, 141(2-3):271-3, 2012.11 DOI: 10.1016/j.schres.2012.07.020
  3. Okada T, *Hashimoto R, Yamamori H, Umeda-Yano S, Yasuda Y, Ohi K, Fukumoto M, Ikemoto K, KUnii Y, Tomita H, Ito A, Takeda M. Expression analysis of a novel mRNA variant of the schizophrenia risk gene ZNF804A. Schizophr Res, 141(2-3):277-8, 2012.11 DOI: 10.1016/j.schres.2012.08.015
  4. Kitazawa M, Ohnuma T, Takebayashi Y, Shibata N, Baba H, Ohi K, Yasuda Y, Nakamura Y, Aleksic B, Yoshimi A, Okochi T, Ikeda M, Naitoh H, Hashimoto R, Iwata N, Ozaki N, Takeda M, Arai H. No Associations Found between the Genes Situated at 6p22.1, HIST1H2BJ, PRSS16 and PGBD1 in Japanese Patients Diagnosed With Schizophrenia. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, 159B(4): 456-64, 2012.6 DOI: 10.1002/ajmg.b.32049
  5. Ohi K, *Hashimoto R, Yasuda Y, Fukumoto M, Yamamori H, Iwase M, Kazui H, Takeda M. Personality traits and schizophrenia: evidence from a case-control study and meta-analysis. Psychiatry Research, 198(1):7-11, 2012.6 DOI: 10.1016/j.psychres.2011.12.018
  6. Ohi K, *Hashimoto R, Yasuda Y, Fukumoto M, Yamamori H, Umeda-Yano S, Okada T, Kamino K, Morihara T, Iwase M, Kazui H, Numata S, Ikeda M, Ohmura T, Iwata N, Ueno S, Ozaki N, Ohmori T, Arai H, Takeda M. Functional genetic variation at the NRGN gene and schizophrenia: evidence from a gene-based case-control study and gene expression analysis. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, 159B(4):405-13, 2012.6 DOI: 10.1002/ajmg.b.32043
  7. Wallwork RS, Fortgang R, Hashimoto R, Weinberger DR, Dickinson D. Searching for a consensus five-factor model of the Positive and Negative Syndrome Scale for schizophrenia. Schizophr Res, 137(1-3):246-50, 2012.5 DOI: 10.1016/j.schres.2012.01.031
  8. Watanabe Y, Egawa J, Iijima Y, Nunokawa A, Kaneko N, Shibuya M, Arinami T, Ujike H, Inada T, Iwata N, Tochigi M, Kunugi H, Itokawa Ma, Ozaki N, Hashimoto R, Someya T. A two-stage case-control association study between the tryptophan hydroxylase 2(TPH2) gene and schizophrenia in a Japanese population. Schizophrenia Research, 137:264-266, 2012.5 DOI: 10.1016/j.schres.2012.01.034
  9. Koide T, Banno M, Aleksic B, Yamashita S, Kikuchi T, Kohmura K, Adachi Y, Kawano N, Kushima I, Nakamura Y, Okada T, Ikeda M, Ohi K, Yasuda Y, Hashimoto R, Inada T, Ujiike H, Iidaka T, Suzuki M, Takeda M, Iwata N, Ozaki N. Common Variants in MAGI2 Gene Are Associated with Increased Risk for Cognitive Impairment in Schizophrenic Patients. PLos One, 7(5):e36836, 2012.5 DOI: 10.1371/journal.pone.0036836
  10. Kushima I, Nakamura Y, Aleksic B, Ikeda M, Ito Y, Shiino T, Okochi T, Fukuo Y, Ujike H, Suzuki M, Inada T, Hashimoto R, Takeda M, Kaibuchi K, Iwata N, Ozaki N. Resequencing and Association Analysis of the KALRN and EPHB1 Genes And Their Contribution to Schizophrenia Susceptibility. Schizophr Bull, 38(3):552-560, 2012.5 DOI: 10.1093/schbul/sbq118
  11. Ohi K, *Hashimoto R, Nakazawa T, Okada T, Yasuda Y, Yamamori H, Fukumoto M, Umeda-Yano S, Iwase M, Kazui H, Yamamoto T, Kano M, Takeda M. The p250GAP Gene is Associated with Risk for Schizophrenia and Schizotypal Personality Traits. PLoS One, 7(4):e35696, 2012.4 DOI: 10.1371/journal.pone.0035696
  12. Yamamori H, *Hashimoto R, Ohi K, Yasuda Y, Fukumoto M, Kasahara E, Sekiyama A, Umeda-Yano S, Okada T, Iwase M, Kazui H, Ito A, Takeda M. A promoter variant in the Chitinase 3-Like 1 gene is associated with serum YKL-40 level and personality trait. Neurosci Lett, 513(3):204-208, 2012.4 DOI: 10.1016/j.neulet.2012.02.039
  13. Takahashi H, Iwase M, Yasuda Y, Ohi Y, Fukumoto M, Iike N, Yamamori H, Nakahachi T, Ikezawa K, Azechi M, Canuet L, Ishii R, Kazui H, Hashimoto R, Takeda M. Relationship of Prepulse Inhibition to Temperament and Character in Healthy Japanese subjects. Neuroscience Research 72(2):187-193, 2012.2 DOI: 10.1016/j.neures.2011.10.009
  14. Ohi K, *Hashimoto R, Yasuda Y, Nemoto K, Ohnishi T, Fukumoto M, Yamamori H, Umeda-Yano S. Okada T, Iwase M, Kazui H, Takeda M. Impact of the Genome Wide Supported NRGN Gene on Anterior Cingulate Morphology in Schizophrenia. PLoS One, 7(1):e29780, 2012.1 DOI: 10.1371/journal.pone.0029780

2011年

  1. Ota M, Fujii T, Nemoto K, Tatsumi M, Moriguchi Y, Hashimoto R, Sato N, Iwata N, Kunugi H. A polymorphism of the ABCA1 gene confers susceptibility to schizophrenia and related brain changes. Prog Neuropsychopharmacol Biol Psychiatry. 35(8):1877-1883, 2011.12 DOI: 10.1016/j.pnpbp.2011.07.012
  2. Takahashi H, Hashimoto R, Iwase M, Ishii R, Kamino Y, Takeda M. Prepulse inhibition of startle response: recent advances in human studies of psychiatric disease. Clinical Psychopharmacology and Neuroscience. 9(3):102-110, 2011.12 DOI: 10.9758/cpn.2011.9.3.102
  3. Ikezawa K, Ishii R, Iwase M, Kurimoto R, Canuet L, Takahashi H, Nakahachi T, Azechi M, Ohi K, Fukumoto M, Yasuda Y, Iike N, Takaya M, Yamamori H, Kazui H, Hashimoto R, Yoshimine T, Takeda M. Decreased alpha event-related synchronization in the left posterior temporal cortex in schizophrenia: A magnetoencephalography-beamformer study. Neurosci Res. 71(3):235-43, 2011.11 DOI: 10.1016/j.neures.2011.07.1819
  4. *Hashimoto R, Ohi K, Yasuda Y, Fukumoto M, Yamamori H, Takahashi H, Iwase M, Okochi T, Kazui H, Saitoh O, Tatsumi M, Iwata N, Ozaki N, Kamijima K, Kunugi H, Takeda M. Variants of the RELA gene are associated with schizophrenia and their startle responses. Neuropsychopharmacology, 36(9):1921-1931, 2011.8 DOI: 10.1038/npp.2011.78
  5. Yamamori H, *Hashimoto R, Verrall L, Yasuda Y, Ohi K, Fukumoto M, Umeda-Yano S, Ito A, Takeda M. Dysbindin-1 and NRG-1 gene expression in immortalized lymphocytes from patients with schizophrenia, J Hum Genet, 56(7):478-83, 2011.7 DOI: 10.1038/jhg.2011.40
  6. Ohi K, *Hashimoto R, Yasuda Y, Fukumoto M, Yamamori H, Umeda-Yano S, Kamino K, Ikezawa K, Azechi M, Iwase M, Kazui H, Kasai K, Takeda M. The SIGMAR1 gene is associated with a risk of schizophrenia and activation of the prefrontal cortex. Prog Neuropsychopharmacol Biol Psychiatry, 35:1309-1315, 2011.7 DOI: 10.1016/j.pnpbp.2011.04.008
  7. *Hashimoto R, Ohi K, Yasuda Y, Fukumoto M, Yamamori H, Kamino K, Morihara T, Iwase M, Kazui H, Numata S, Ikeda M, Ueno S, Ohmori T, Iwata N, Ozaki N, Takeda M. No association between the PCM1 gene and schizophrenia: a multi-center case-control study and a meta-analysis. Schizophrenia Res, 129:80-84, 2011.6 DOI: 10.1016/j.schres.2011.03.024
  8. Yasuda Y, *Hashimoto R, Yamamori H, Ohi K, Fukumoto M, Umeda-Yano S, Mohri I, Ito A, Taniike M, Takeda M. Gene expression analysis in lymphoblasts derived from patients with autism spectrum disorder. Molecular Autism, 2(1):9, 2011.5 DOI: 10.1186/2040-2392-2-9
  9. Yasuda Y, *Hashimoto R, Ohi K , Fukumoto M, Umeda-Yano S, Yamamori H, Okochi T, Iwase M, Kazui H, Iwata N, Takeda M. Impact on schizotypal personality trait of a genome-wide supported psychosis variant of the ZNF804A gene. Neurosci let, 495:216-220, 2011.5 DOI: 10.1016/j.neulet.2011.03.069
  10. Hashimoto H, Shintani N, Tanida M, Hayata A, Hashimoto R, Baba A. PACAP is Implicated in the Stress Axes, Curr Pharm Des, review, 17(10):985-9, 2011.4 DOI: 10.2174/138161211795589382
  11. Kobayashi K, Umeda-Yano S, Yamamori H, Takeda M, Suzuki H, Hashimoto R. Correlated Alterations in Serotonergic and Dopaminergic Modulations at the Hippocampal Mossy Fiber Synapse in Mice Lacking Dysbindin. PLoS One, 23;6(3):e18113, 2011.3 DOI: 10.1371/journal.pone.0018113
  12. Ikeda M, Aleksic B, Kinoshita Y, Okochi T, Kawashima K, Kushima I, Ito Y, Nakamura Y, Kishi T, Okumura T, Fukuo Y, Williams HJ, Hamshere ML, Ivanov D, Inada T, Suzuki M, Hashimoto R, Ujike H, Takeda M, Craddock N, Kaibuchi K, Owen MJ, Ozaki N, O'Donovan MC, Iwata N. Genome-Wide Association Study of Schizophrenia in a Japanese Population. Biol Psychiatry, 69(5):472-478, 2011.3. DOI: 10.1016/j.biopsych.2010.07.010
  13. Cacabelos R, Hashimoto R, Takeda M. Pharmacogenomics of antipsychotics efficacy for schizophrenia. Psychiatry Clin Neurosci. 65(1):3-19, 2011.2 DOI: 10.1111/j.1440-1819.2010.02168.x
  14. Kazui H, Yoshida T, Takaya M, Sugiyama H, Yamamoto D, Kito Y, Wada T, Nomura K, Yasuda Y, Yamamori H, Ohi K, Fukumoto M, Iike N, Iwase M, Morihara T, Tagami S, Shimosegawa E, Hatazawa J, Ikeda Y, Uchida E, Tanaka T, Kudo T, Hashimoto R, Takeda M. Different Characteristics of Cognitive Impairment in Elderly Schizophrenia and Alzheimer’s Disease in the Mild Cognitive Impairment Stage. Dement Geriatr Cogn Disord. 2011:1:20-30, 2011.1 DOI: 10.1159/000323561
  15. Nihonmatsu-Kikuchi N, Hashimoto R, Hattori S, Matsuzaki S, Shinozaki T, Miura H, Ohota S, Tohyama M, Takeda M, Tatebayashi Y. Reduced rate of neural differentiation in the dentate gyrus of adult dysbindin null (sandy) mouse. PLoS One, 18;6(1):e15886, 2011.1 DOI: 10.1371/journal.pone.0015886

2010年

  1. *Hashimoto R, Ohi K, Yasuda Y, Fukumoto M, Iwase M, Iike N, Azechi M, Ikezawa K, Takaya M, Takahashi H, Yamamori H, Okochi T, Tanimukai H, Tagami S, Morihara T, Okochi M, Tanaka T, Kudo T, Kazui H, Iwata N, Takeda M. The Impact of a Genome-Wide Supported Psychosis Variant in the ZNF804A Gene on Memory Function in Schizophrenia. Am J Med Genet B Neuropsychiatry Genet, 153B(8):1459-1464, 2010.12 DOI: 10.1002/ajmg.b.31123
  2. Takeda M, Martinez R, Kudo T, Tanaka T, Okochi M, Tagami S, Morihara T, Hashimoto R, Cacabelos R. Apolipoprotein E and central nervous system disorders: reviews of clinical findings. Psychiatry Clin Neurosci. 64(6):592-607, 2010.12 DOI: 10.1111/j.1440-1819.2010.02148.x
  3. Delawary M, Tezuka T, Kiyama Y, Yokoyama K, Inoue T, Hattori S, Hashimoto R, Umemori H, Manabe T, Yamamoto T, Nakazawa T. NMDAR2B tyrosine phosphorylation regulates anxiety-like behavior and CRF expression in the amygdala. Mol Brain.3(1):37, 2010.11. DOI: 10.1186/1756-6606-3-37
  4. Hayashi N, Kazui H, Kamino K, Tokunaga H, Takaya M, Yokokoji M, Kimura R, Kito Y, Wada T, Nomura K, Sugiyama H, Yamamoto D, Yoshida T, Currais A, Soriano S, Hamasaki T, Yamamoto M, Yasuda Y, Hashimoto R, Tanimukai H, Tagami S, Okochi M, Tanaka T, Kudo T, Morihara T, Takeda M. KIBRA genetic polymorphism influences episodic memory in Alzheimer's disease, but does not show association with disease in a Japanese cohort. Dement Geriatr Cogn Disord. 30(4):302-308, 2010.10. DOI: 10.1159/000320482
  5. Yasuda Y, *Hashimoto R, Ohi K, Fukumoto M, Takamura H, Iike N, Kiribayashi M, Yoshida T, Hayashi N, Takahashi H, Yamamori H, Morihara T, Tagami S, Okochi M, Tanaka T, Kudo T, Kamino K, Ishii R, Iwase M, Kazui H, Takeda M. Association study of KIBRA gene with memory performance in a Japanese population. World J Biol Psychiatry, 11(7):852-857.2010.10 DOI: 10.3109/15622971003797258
  6. Numata S, Nakataki M, Iga J, Tanahashi T, Nakadoi Y, Ohi K, Hashimoto R, Takeda M, Itakura M, Ueno S, Ohmori T. Association study between the pericentrin (PCNT) gene and schizophrenia. Neuromolecular Med, 12(3):243-247. 2010.9 DOI: 10.1007/s12017-009-8106-x
  7. Takahashi H, Iwase M, Canuet L, Yasuda Y, Ohi K, Fukumoto M, Iike N, Nakahachi T, Ikezawa K, Azechi M, Kurimoto R, Ishii R, Yoshida T, Kazui H, Hashimoto R, Takeda M. Relationship between prepulse inhibition of acoustic startle response and schizotypy in healthy Japanese subjects. Psychophysiology, 47(5):831-837. 2010.9 DOI: 10.1111/j.1469-8986.2010.01000.x
  8. Mori K, Okochi M, Tagami S, Nakayama T, Yanagida K, Kodama T, Tatsumi S, Fujii K, Tanimukai H, Hashimoto R, Morihara T, Tanaka T, Kudo T, Funamoto S, Ihara Y, Takeda M. The production ratios of AICDε51 and Aβ42 by intramembrane proteolysis of βAPP do not always change in parallel. Psychogeriatrics, 10(3):117-123, 2010.9 DOI: 10.1111/j.1479-8301.2010.00330.x
  9. Takebayashi M, Hashimoto R, Hisaoka K, Tsuchioka M, Kunugi H. Plasma levels of vascular endothelial growth factor (VEGF) and fibroblast growth factor 2 (FGF-2) in patients with major depressive disorders. J Neural Transm. 117(9):1119-1122. 2010.9 DOI: 10.1007/s00702-010-0452-1
  10. Koide T, Aleksic B, Ito Y, Usui H, Yoshimi A, Inada T, Suzuki M, Hashimoto R, Takeda M, Iwata N, Ozaki N. A two-stage case-control association study of the dihydropyrimidinase-like 2 gene (DPYSL2) with schizophrenia in Japanese subjects. J Hum Genet. 55(7):469-472. 2010.7 DOI: 10.1038/jhg.2010.38
  11. Takeda M, Hashimoto R, Kudo T, Okochi M, Tagami S, Morihara T, Sadick G, Tanaka T. Laughter and humor as complementary and alternative medicines to dementia patients. BMC Complement Altern Med, 10(1):28, 2010.6 DOI: 10.1186/1472-6882-10-28
  12. Schulze T, Alda M, Adli M, Akula N, Ardau R, Chillotti C, Cichon S, Czerski P, Zompo M, SDetera-Wadleigh S, Grof P, Gruber O, Hashimoto R, Hauser J, Hoban R, Iwata N, Kassem L, Kato T, Kittel-Schneider S, Kliwicki S, Kelsoe J, Kusumi I, Laje G, Leckband S, Manchia M, MacQueen G, Masui T, Ozaki N, Perlis R, Pfennig A, Piccardi P, Richardson S, Rouleau G, Reif A, Rybakowski J, Sasse J, Schumacher J, Severino G, Smoller J, Squassina A, Turecki G, Young T, Yoshikawa T, Bauer M, McMahon F. The International Consortium on Lithium Genetics (ConLiGen): An Initiative by the NIMH and IGSLI to Study the Genetic Basis of Response to Lithium Treatment, Neuropsychobiology, 62(1):72-78, 2010.6 DOI: 10.1159/000314708
  13. Munesue T, Yokoyama S, Nakamura K, Anitha A, Yamada K, Hayashi K, Asaka T, Liu HX, Jin D, Koizumi K, Islam MS, Huang JJ, Ma WJ, Kim UH, Kim SJ, Park K, Kim D, Kikuchi M, Ono Y, Nakatani H, Suda S, Miyachi T, Hirai H, Salmina A, Pichugina YA, Soumarokov AA, Takei N, Mori N, Tsujii M, Sugiyama T, Yagi K, Yamagishi M, Sasaki T, Yamasue H, Kato N, Hashimoto R, Taniike M, Hayashi Y, Hamada J, Suzuki S, Ooi A, Noda M, Kamiyama Y, Kido MA, Lopatina O, Hashii M, Amina S, Malavasi F, Huang EJ, Zhang J, Shimizu N, Yoshikawa T, Matsushima A, Minabe Y, Higashida H. Two genetic variants of CD38 in subjects with autism spectrum disorder and controls. Neurosci Res, 67:181-191, 2010.6 DOI: 10.1016/j.neures.2010.03.004
  14. Amagane H, Watanabe Y, Kaneko N, Nunokawa A, Muratake T, Ishiguro H, Arinami T, Ujike H, Inada T, Iwata N, Kunugi H, Sasaki T, Hashimoto R, Itokawa M, Ozaki N, Someya T. Failure to find an association between myosin heavy chain 9, non-muscle (MYH9) and schizophrenia: a three-stage case-control association study. Schizophr Res, 118(1-3):106-112, 2010.5 DOI: 10.1016/j.schres.2010.01.023
  15. Ohnuma T, Shibata N, Baba H, Ohi K, Yasuda Y, Nakamura Y, Okochi T, Naitoh H, Hashimoto R, Iwata N, Ozaki N, Takeda M, Arai H. No association between DAO and schizophrenia in a Japanese patient population: A multicenter replication study. Schizophr Res, 118(1-3):300-302, 2010.5 DOI: 10.1016/j.schres.2010.01.028
  16. Fukuda S, Hashimoto R, Ohi K, Yamaguti K, Nakatomi Y, Yasuda Y, Kamino K, Takeda M, Tajima S, Kuratsune H, Nishizawa Y, Watanabe Y. A functional polymorphism in the disrupted-in schizophrenia 1 gene is associated with chronic fatigue syndrome. Life Sci, 86(19-20):722-725, 2010.5 DOI: 10.1016/j.lfs.2010.03.007
  17. Aleksic B, Kushima I, Ito Y, Nakamura Y, Ujike H, Suzuki M, Inada T, Hashimoto R, Takeda M, Iwata N, Ozaki N. Genetic association study of KREMEN1 and DKK1 and schizophrenia in a Japanese population. Schizophr Res, 118(1-3):113-117, 2010.5 DOI: 10.1016/j.schres.2010.01.014
  18. Azechi M, Iwase M, Ikezawa K, Takahashi H, Canuet L, Kurimoto R, Nakahachi T, Ishii R, Fukumoto M, Ohi K, Yasuda Y, Kazui H, Hashimoto R, Takeda M. Discriminant analysis in schizophrenia and healthy subjects using prefrontal activation during frontal lobe tasks: A near-infrared spectroscopy. Schizophr Res, 117(1):52-60, 2010.3 DOI: 10.1016/j.schres.2009.10.003
  19. *Hashimoto R, Noguchi H, Hori H, Nakabayashi T, Suzuki T, Iwata N, Ozaki N, Kosuga A, Tatsumi M, Kamijima K, Harada S, Takeda M, Saitoh O, Kunugi H. A genetic variation in the dysbindin gene (DTNBP1) is associated with memory performance in healthy controls. World J Biol Psychiatry 11:431-438. 2010.3 DOI: 10.1080/15622970902736503
  20. Ikeda M, Tomita Y, Mouri A, Koga M, Okochi T, Yoshimura R, Yamanouchi Y, Kinoshita Y, Hashimoto R, Williams H, Takeda M, Nakamura J, Nabeshima T, Owen M, O'Donovan M, Honda H, Arinami T, Ozaki N, Iwata N. Identification of novel candidate genes for treatment response to risperidone and susceptibility for schizophrenia: integrated analysis among pharmacogenomics, mouse expression and genetic case-control association approaches. Biol Psychiatry, 67(3):263-269, 2010.2 DOI: 10.1016/j.biopsych.2009.08.030
  21. Ohi K, *Hashimoto R, Yasuda Y, Yoshida T, Takahashi H, Iike N, Iwase M, Kamino K, Ishii R, Kazui H, Fukumoto M, Takamura H, Yamamori H, Azechi M, Ikezawa K, Tanimukai H, Tagami S, Morihara T, Okochi M, Yamada K, Numata S, Ikeda M, Tanaka T, Kudo T, Ueno S, Yoshikawa T, Ohmori T, Iwata N, Ozaki N, Takeda M. The Chitinase 3-Like 1 gene and schizophrenia: evidence from a multi-center case-control study and meta-analysis. Schizophr Res, 116:126-132, 2010.2 DOI: 10.1016/j.schres.2009.12.002
  22. *Hashimoto R, Hashimoto H, Shintani N, Ohi K, Hori H, Saitoh O, Kosuga A, Tatsumi M, Iwata N, Ozaki N, Kamijima K, Baba A, Takeda M, Kunugi H. Possible association between the pituitary adenylate cyclase-activating polypeptide (PACAP) gene and major depressive disorder. Neurosci Lett, 468(3):300-302, 2010.1 DOI: 10.1016/j.neulet.2009.11.019
  23. Canuet L, Ishii R, Iwase M, Ikezawa K, Kurimoto R, Takahashi H, Currais A, Azechi M, Nakahachi T, Hashimoto R, Takeda M. Working memory abnormalities in chronic interictal epileptic psychosis and schizophrenia revealed by magnetoencephalography. Epilepsy Behav. 17(1):109-119, 2010.1 DOI: 10.1016/j.yebeh.2009.11.002
  24. Okuda H, Kuwahara R, Matsuzaki S, Miyata S, Kumamoto N, Hattori T, Shimizu S, Yamada K, Kawamoto K, Hashimoto R, Takeda M, Katayama T, Tohyama M. Dysbindin regulates the transcriptional level of myristoylated alanine-rich protein kinase C substrate via the interaction with NF-YB in mice brain. PLoS One, 5(1):e8773, 2010.1 DOI: 10.1371/journal.pone.0008773
  25. Nunokawa A, Watanabe Y, Kaneko N, Sugai T, Yazaki S, Arinami T, Ujike H, Inada T, Iwata N, Kunugi H, Sasaki T, Itokawa M, Ozaki N, Hashimoto R, Someya T. The dopamine D3 receptor (DRD3) gene and risk of schizophrenia: case-control studies and an updated meta-analysis. Schizophr Res, 116(1):61-67, 2010.1 DOI: 10.1016/j.schres.2009.10.016

2009年

  1. Moriwaki M, Kishi T, Takahashi H, Hashimoto R, Kawashima K, Okochi T, Furukawa O, Fujita K, Takeda M, Iwata N. Prepulse inhibition of the startle response with chronic schizophrenia: A replication study. Neurosci Res, 65(3):259-262, 2009.11 DOI: 10.1016/j.neures.2009.07.009
  2. *Hashimoto R, Ohi K, Okada T, Yasuda Y, Yamamori H, Hori H, Hikita T, Taya S, Saitoh O, Kosuga A, Tatsumi M, Kamijima K, Kaibuchi K, Takeda M, Kunugi H. Association analysis between schizophrenia and the AP-3 complex genes. Neurosci Res, 65(1):113-115, 2009.9 DOI: 10.1016/j.neures.2009.05.008
  3. Hikita T, Taya S, Fujino Y, Taneichi-Kuroda S, Ohta K, Tsuboi D, Shinoda T, Kuroda K, Funahashi Y, Uraguchi-Asaki J, Hashimoto R, Kaibuchi K. Proteomic analysis reveals novel binding partners of dysbindin, a schizophrenia-related protein. J Neurochem, 110(5):1567-1574, 2009.9 DOI: 10.1016/j.neures.2009.05.008
  4. Ohi K, *Hashimoto R, Yasuda Y, Yamamori H, Hori H, Saitoh O, Tatsumi M, Takeda M, Iwata N, Ozaki N, Kamijima K, Kunugi H. No association between the Bcl2-interacting killer (BIK) gene and schizophrenia. Neurosci Lett, 463(1):60-63, 2009.9 DOI: 10.1016/j.neulet.2009.07.063
  5. *Hashimoto R, Noguchi H, Hori H, Ohi K, Yasuda Y, Takeda M, Kunugi H. Association between the dysbindin gene (DTNBP1) and cognitive functions in Japanese subjects. Psychiatry Clin Neurosci 63(4):550-556, 2009.8 DOI: 10.1111/j.1440-1819.2009.01985.x
  6. Hashimoto H, Hashimoto R, Shintani N, Tanaka K, Yamamoto A, Hatanaka M, Guo X, Morita Y, Tanida M, Nagai K, Takeda M, Baba A. Depression-like behavior in the forced swimming test in PACAP-deficient mice: amelioration by the atypical antipsychotic risperidone. J Neurochem, 110(2):595-602, 2009.7 DOI: 10.1111/j.1471-4159.2009.06168.x
  7. Yanagida K, Okochi M, Tagami S, Nakayama T, Kodama T, Nishitomi K, Jiang J, Mori K, Tatsumi S, Arai T, Ikeuchi T, Kasuga K, Tokuda T, Kondo M, Ikeda K, Deguchi K, Kazui H, Tanaka T, Morihara T, Hashimoto R, Kudo T, Steiner H, Haass C, Tsuchiya K, kiyama H, Kuwano R, Takeda M. The 28-amino acid form of an APLP1-derived Aβ-like peptide is a surrogate marker for Aβ42 production in the central nervous system. EMBO Mol Med, 1:223-235, 2009.7 DOI: 10.1002/emmm.200900026
  8. Kubota K, Inoue K, Hashimoto R, Kumamoto N, Kosuga A, Tatsumi M, Kamijima K, Kunugi H, Iwata N, Ozaki N, Takeda M, Tohyama M. Tumor necrosis factor receptor-associated protein 1 regulates cell adhesion and synaptic morphology via modulation of N-cadherin expression. J Neurochem, 110(2):496-508, 2009.7 DOI: 10.1111/j.1471-4159.2009.06099.x
  9. Ohi K, *Hashimoto R, Yasuda Y, Yoshida T, Takahashi H, Iike N, Fukumoto M, Takamura H, Iwase M, Kamino K, Ishii R, Kazui H, Sekiyama R, Kitamura Y, Azechi M, Ikezawa K, Kurimoto R, Kamagata E, Tanimukai H, Tagami S, Morihara T, Ogasawara M, Okochi M, Tokunaga H, Numata S, Ikeda M, Ohnuma T, Ueno S, Fukunaga T, Tanaka T, Kudo T, Arai H, Ohmori T, Iwata N, Ozaki N, Takeda M. Association study of the G72 gene with schizophrenia in a Japanese population: a multicenter study. Schizophr Res, 109(1-3), 80-85, 2009.4 DOI: 10.1016/j.schres.2009.01.019
  10. Ohi K, *Hashimoto R, Yasuda Y, Kiribayashi M, Iike N, Yoshida T, Azechi M, Ikezawa K, Takahashi H, Morihara T, Ishi R, Tagami S, Iwase M, Okochi M, Kamino K, Kazui H, Tanaka T, Kudo T, Takeda M. TATA Box-Binding Protein gene is associated with risk for schizophrenia, age at onset and prefrontal function. Genes Brain Behav, 8(4):473-480, 2009.6 DOI: 10.1111/j.1601-183X.2009.00497.x
  11. Ikezawa K, Iwase M, Ishii R, Azechi M, Canuet L, Ohi K, Yasuda Y, Iike N, Kurimoto R, Takahashi H, Nakahachi T, Sekiyama R, Yoshida T, Kazui H, Hashimoto R, Takeda M. Impaired regional hemodynamic response in schizophrenia during multiple prefrontal activation tasks: a two-channel near-infrared spectroscopy study. Schizophr Res 108(1-3):93-103, 2009.3 DOI: 10.1016/j.schres.2008.12.010
  12. Kubota K, Kumamoto N, Matsuzaki S, Hashimoto R, Hattori T, Okuda H, Takamura H, Takeda M, Katayama T, Tohyama M. Dysbindin engages in c-Jun N-terminal kinase activity and cytoskeletal organization. Biochem Biophys Res Commun, 379(2), 191-195, 2009.2 DOI: 10.1016/j.bbrc.2008.12.017
  13. *Hashimoto R, Hirata Y, Asada T, Yamashita F, Nemoto K, Mori T, Moriguchi Y, Kunugi H, Arima K, Ohnishi T. Effect of the BDNF and the ApoE polymorphisms on disease progression in preclinical Alzheimer's disease. Genes Brain Behav, 8(1), 43-52, 2009.2 DOI: 10.1111/j.1601-183X.2008.00440.x
  14. *Hashimoto R, Mori T, Nemoto K, Moriguchi Y, Noguchi H, Nakabayashi T, Hori H, Harada S, Kunugi H, Saitoh O, Ohnishi T. Abnormal microstructures of the basal ganglia in schizophrenia revealed by diffusion tensor imaging. World J Biol Psychiatry, 10(1): 65-69, 2009.1 DOI: 10.1080/15622970701762536

2008年

  1. Takahashi H, Iwase M, Ishii R, Ohi K, Fukumoto M, Azechi M, Ikezawa K, Kurimoto R, Canuet L, Nakahachi T, Iike N, Tagami S, Morihara T, Okochi M, Tanaka T, Kudo T, Yoshida T, Yasuda Y, Hashimoto R, Takeda M. Impaired prepulse inhibition and habituation of acoustic startle response in Japanese patients with schizophrenia. Neurosci Res, 62(3), 187-194, 2008.11 DOI: 10.1016/j.neures.2008.08.006
  2. Ohi K, *Hashimoto R, Sugai F, Yasuda Y, Tagami S, Takamura H, Morihara T, Okochi M, Tanaka T, Kudo T, Sakoda S, Takeda M. Difficulty identifying spinocerebellar ataxia 17 from preceding psychiatric symptoms. Psychiatry Clin Neurosci, 62(5), 625, 2008. 10 DOI: 10.1111/j.1440-1819.2008.01860.x
  3. Takao K, Toyama K, Nakanishi K, Hattori S, Takamura H, Takeda M, Miyakawa T, Hashimoto R. Impaired long-term memory retention and working memory in sdy mutant mice with a deletion in Dtnbp1, a susceptibility gene for schizophrenia. Mol Brain, 1(1):11, 2008.10 DOI: 10.1186/1756-6606-1-11
  4. Kawashima K, Kishi T, Ikeda M, Kitajima T, Yamanouchi Y, Kinoshita Y, Takahashi N, Saito S, Ohi K, Yasuda Y, Hashimoto R, Takeda M, Inada T, Ozaki N, Iwata N. No Association between Tagging SNPs of SNARE Complex Genes (STX1A, VAMP2 and SNAP25) and Schizophrenia in a Japanese Population. Am J Med Genet. 147B(7):1327-1331, 2008.10 DOI: 10.1002/ajmg.b.30781
  5. Mizuguchi T, Hashimoto R, Itokawa M, Sano A, Shimokawa O, Yoshimura Y, Harada N, Miyake N, Nishimura A, Saitsu H, Sosonkina N, Niikawa N, Kunugi H, Matsumoto N. Microarray comparative genomic hybridization analysis of 59 patients with schizophrenia. J Hum Genet, 53(10):914-919, 2008.8 DOI: 10.1007/s10038-008-0327-6
  6. Hattori S, Murotani T, Matsuzaki S, Ishizuka T, Kumamoto N, Takeda M, Tohyama M, Yamatodani A, Kunugi H, *Hashimoto R. Behavioral abnormalities and dopamine reductions in sdy mutant mice with a deletion in Dtnbp1, a susceptibility gene for schizophrenia. Biochem Biophys Res Commun, 373(2):298-302, 2008.8 DOI: 10.1016/j.bbrc.2008.06.016
  7. *Hashimoto R, Moriguchi Y, Yamashita F, Mori T, Nemoto K, Okada T, Hori H, Noguchi H, Kunugi H, Ohnishi T. Dose Dependent Effect of the Val66Met Polymorphism of the Brain-Derived Neurotrophic Factor Gene on Memory-Related Hippocampal Activity. Neuroscience Res, 61(4):360-367, 2008.8 DOI: 10.1016/j.neures.2008.04.003
  8. Hori H, Noguchi H, Hashimoto R, Nakabayashi T, Saitoh O, Murray RM, Okabe S, Kunugi H. Personality in schizophrenia assessed with the Temperament and Character Inventory (TCI), Psychiatry Res, 160(2):175-183, 2008.8 DOI: 10.1016/j.psychres.2007.05.015
  9. Midorikawa A, Hashimoto R, Noguchi H, Saitoh O, Kunugi H, Nakamura K. Impairment of motor dexterity in schizophrenia assessed by a novel finger-movement test, Psychiatry Res, 159:281-289, 2008.6 DOI: 10.1016/j.psychres.2007.04.004
  10. Numata S, Shu-ichi Ueno S, Iga J, Yamauchi K, Hongwei S, Hashimoto R, Takeda M, Kunugi H, Itakura M, Ohmori T. TGFBR2 Gene expression and genetic association with schizophrenia. J Psychiatr Res, 42(6):425-432, 2008.5 DOI: 10.1016/j.jpsychires.2007.04.002
  11. Ikeda M, Takahashi N, Saito S, Aleksic B, Watanabe Y, Nunokawa A, Yamanouchi Y, Kitajima T, Kinoshita Y, Kishi T, Kawashima K, Hashimoto R, Ujike H, Inada T, Someya T, Takeda M, Ozaki N, Iwata N. Failure to replicate the association between NRG1 and schizophrenia using Japanese large-sample. Schizophr Res, 101:1-8, 2008.4 DOI: 10.1016/j.schres.2008.01.010
  12. Hori H, Noguchi H, Hashimoto R, Saitoh O, Okabe S, Kunugi H. IQ decline and memory impairment in Japanese patients with chronic schizophrenia, Psychiatry Res, 158:251-255, 2008.3 DOI: 10.1016/j.psychres.2007.11.002
  13. Numata S, Ueno S, Iga J, Nakataki M, Tanahashi T, Itakura M, Sano A, Ohi K, Hashimoto R, Takeda M, Ohmori T. No association between the NDE1 gene and schizophrenia in the Japanese Population. Schizophr Res, 99(1-3):367-369, 2008.2 DOI: 10.1016/j.schres.2007.10.032
  14. Masui T, *Hashimoto R, Kusumi I, Suzuki K, Tanaka T, Nakagawa S, Suzuki T, Iwata N, Ozaki N, Kato T, Takeda M, Kunugi H, Koyama T. A possible association between missense polymorphism of the Breakpoint Cluster Region gene and lithium prophylaxis in bipolar disorder, Prog Neuropsychopharmacol Biol Psychiatry, 32:204-208, 2008.1 DOI: 10.1016/j.pnpbp.2007.08.010
  15. Aidaralieva NJ, Kamino K, Kimura R, Yamamoto M, Morihara T, Kazui H, Hashimoto R, Tanaka T, Kudo T, Kida T, Okuda JI, Uema T, Yamagata H, Miki T, Akatsu H, Kosaka K, Takeda M. Dynamin 2 gene is a novel susceptibility gene for late-onset Alzheimer disease in non-APOE-epsilon4 carriers. J Hum Genet, 53(4):296-302, 2008.1 DOI: 10.1007/s10038-008-0251-9
  16. Tagami S, Okochi M, Yanagida K, Ikuta A, Fukumori A, Matsumoto N, Ishizuka-Katsura Y, Nakayama T, Itoh N, Jiang J, Nishitomi K, Kamino K, Morihara T, Hashimoto R, Tanaka T, Kudo T, Chiba S, Takeda M. Regulation of notch signaling by dynamic changes in the precision of s3 cleavage of notch-1, Mol Cell Biol, 28(1):165-176, 2008.1 DOI: 10.1128/MCB.00863-07

2007年

  1. *Hashimoto R, Hashimoto H, Shintani N, Chiba S, Hattori S, Okada T, Nakajima M, Tanaka K, Kawagishi N, Nemoto K, Mori T, Ohnishi T, Noguchi H, Hori H, Suzuki T, Iwata N, Ozaki N, Nakabayashi T, Saitoh O, Kosuga A, Tatsumi M, Kamijima K, Weinberger DR, Kunugi H, Baba A. Pituitary adenylate cyclase-activating polypeptide is associated with schizophrenia, Mol Psychiatry, 12:1026-1032, 2007.11 DOI:10.1038/sj.mp.4001982
  2. *Hashimoto R, Noguchi H, Hori H, Ohi K, Yasuda Y, Takeda M, Kunugi H. A possible association between the Val158Met polymorphism of the catechol-O-methyl transferase gene and the personality trait of harm avoidance in Japanese healthy subjects, Neurosci lett, 428(1):17-20, 2007.11 DOI: 10.1016/j.neulet.2007.09.036
  3. Kunugi H, Tanaka M, Hori H, Hashimoto R, Saitoh O, Hironaka N. Prepulse inhibition of acoustic startle in Japanese patients with chronic schizophrenia, Neuroscience Res, 59(1):23-28, 2007.9 DOI: 10.1016/j.neures.2007.05.006
  4. Hashimoto R, Tankou S, Takeda M, Sawa A. Postsynaptic density: A key convergent site for schizophrenia susceptibility factors and possible target for drug development. Drugs Today (Barc). 43(9):645-654, 2007.9 DOI: 10.1358/dot.2007.43.9.1088821
  5. Murotani T, Ishizuka T, Hattori S, Hashimoto R, Matsuzaki S, Yamatodani A. High dopamine turnover in the brains of Sandy mice. Neurosci Lett. 421(1):47-51, 2007.6 DOI: 10.1016/j.neulet.2007.05.019
  6. Hattori S, *Hashimoto R, Miyakawa T, Yamanaka H, Maeno H, Wada K, Kunugi H. Enriched environments influence depression-related behavior in adult mice and the survival of newborn cells in their hippocampi, Behavioural Brain Res, 180(1):69-76, 2007.6 DOI: 10.1016/j.bbr.2007.02.036
  7. Mori T, Ohnishi T, Hashimoto R, Nemoto K, Moriguchi Y, Noguchi H, Nakabayashi T, Hori H, Harada S, Saitoh O, Matsuda H, Kunugi H. Progressive changes of white matter integrity in schizophrenia revealed by diffusion tensor imaging, Psychiatry Res: Neuroimaging, 154(2):133-145, 2007.2 DOI: 10.1016/j.pscychresns.2006.09.004
  8. Numata S, Ueno S, Iga J, Yamauchi K, Hongwei S, Hashimoto R, Takeda M, Kunugi H, Itakura M, Ohmori T. Gene expression in the peripheral leukocytes and association analysis of PDLIM5 gene in schizophrenia, Neurosci Lett, 415:28-33, 2007.1 DOI: 10.1016/j.neulet.2007.01.018
  9. Hong K, Sugawara Y, Hasegawa H, Hayasaka I, Hashimoto R, Ito S, Inoue-Murayama M. A new gain-of-function allele in chimpanzee tryptophan hydroxylase 2 and the comparison of its enzyme activity with that in humans and rats, Neurosci Lett, 412:195-200, 2007.2 DOI: 10.1016/j.neulet.2006.11.010
  10. Kimura R, Kamino K, Yamamoto M, Nuripa A, Kida T, Kazui H, Hashimoto R, Tanaka T, Kudo T, Yamagata H, Tabara Y, Miki T, Akatsu H, Kosaka K, Funakoshi E, Nishitomi K, Sakaguchi G, Kato A, Hattori H, Uema T, Takeda M. The DYRK1A gene, encoded in chromosome 21 Down syndrome critical region, bridges between {beta}-amyloid production and tau phosphorylation in Alzheimer disease. Hum Mol Genet, 16:15-23, 2007.1 DOI: 10.1093/hmg/ddl437

2006年

  1. *Hashimoto R, Numakawa T, Ohnishi T, Kumamaru E, Yagasaki Y, Ishimoto T, Mori T, Nemoto K, Adachi N, Izumi A, Chiba S, Noguchi H, Suzuki T, Iwata N, Ozaki N, Taguchi T, Kamiya A, Kosuga A, Tatsumi M, Kamijima K, Weinberger DR, Sawa A, Kunugi H. Impact of the DISC1 Ser704Cys polymorphism on risk for major depression, brain morphology, and ERK signaling. Hum Mol Genet, 15:3024-3033, 2006.10 DOI: 10.1093/hmg/ddl244
  2. Kunugi H, Hashimoto R, Okada T, Hori H, Nakabayashi T, Baba A, Kudo K, Ohmori M, Takahashi S, Tsukue R, Anami K, Hirabayashi N, Kosuga A, Tatsumi M, Kamijima K, Asada T, Harada S, Arima K, Saitoh O. Possible association between nonsynonymous polymorphisms of the anaplastic lymphoma kinase (ALK) gene and schizophrenia in a Japanese population. J Neural Transm, 113:1569-1573, 2006.10 DOI: 10.1007/s00702-006-0436-3
  3. Hori H, Noguchi H, Hashimoto R, Nakabayashi T, Omori M, Takahashi S, Tsukue R, Anami K, Hirabayashi N, Harada S, Saitoh O, Iwase M, Kajimoto O, Takeda M, Okabe S, Kunugi H. Antipsychotic medication and cognitive function in schizophrenia. Schizophr Res, 86:138-146, 2006.9 DOI: 10.1016/j.schres.2006.05.004
  4. Chiba S, *Hashimoto R, Hattori S, Yohda M, Lipska B, Weinberger DR, Kunugi H. Effect of antipsychotic drugs on DISC1 and dysbindin expression in mouse frontal cortex and hippocampus. J Neural Transm, 113:1337-1346, 2006.9 DOI:10.1007/s00702-005-0414-1
  5. Okada T, Hashimoto R, Numakawa T, Iijima Y, Kosuga A, Tatsumi M, Kamijima K, Kato T, Kunugi H. A complex polymorphic region in the brain-derived neurotrophic factor (BDNF) gene confers susceptibility to bipolar disorder and affects transcriptional activity. Mol Psychiatry, 11:695-703, 2006.7 DOI:10.1038/sj.mp.4001822
  6. Nakahachi T, Iwase M, Takahashi H, Honaga E, Sekiyama R, Ukai S, Ishii, R, Ishigami W, Kajimoto O, Yamashita K, Hashimoto R, Shimizu A, Takeda M. Discrepancy of performance among working memory related tasks in autism spectrum disorders was caused by task characteristics apart from working memory which could interfere with task execution. Psychiatry Clin Neurosci, 60:312-318, 2006.6 DOI: 10.1111/j.1440-1819.2006.01507.x
  7. Kumamoto N, Matsuzaki S, Inoue K, Hattori T, Shimizu S, Hashimoto R, Yamatodani A, Katayama T, Tohyama M. Hyperactivation of Midbrain Dopaminergic System in Schizophrenia could be attributed to the Down-regulation of Dysbindin. Biochem Biophys Res Commun, 345:904-909, 2006.6 DOI: 10.1016/j.bbrc.2006.04.163
  8. Tanaka K, Shintani N, Hashimoto H, Kawagishi N, Ago Y, Matsuda T, Hashimoto R, Kunugi H, Yamamoto A, Kawaguchi C, Shimada T, Baba A. Psychostimulant-induced attenuation of hyperactivity and prepulse inhibition deficits in Adcyap1-deficient mice. J Neurosci. 26(19):5091-5097, 2006.5 DOI: 10.1523/JNEUROSCI.4376-05.2006
  9. Law AJ, Lipska BK, Weickert CS, Hyde TM, Straub RE, Hashimoto R, Harrison PJ, Kleinman JE, Weinberger DR. Neuregulin 1 transcripts are differentially expressed in schizophrenia and regulated by 5' SNPs associated with the disease. Proc Natl Acad Sci U S A, 103(17):6747-6752, 2006.4 DOI: 10.1073/pnas.0602002103
  10. Masui T, *Hashimoto R, Kusumi I, Suzuki K, Tanaka T, Nakagawa S, Suzuki T, Iwata N, Ozaki N, Kato T, Kunugi H, Koyama T. Lithium response and Val66Met polymorphism of the BDNF gene in Japanese patients with bipolar disorder. Psychiatr Genet, 16(2):49-50, 2006.4 DOI: 10.1097/01.ypg.0000180680.72922.57
  11. Nemoto K, Ohnishi T, Mori T, Moriguchi Y, Hashimoto R, Asada T, Kunugi H. The Val66Met polymorphism of the BDNF gene affects age-related brain morphology. Neurosci Lett 397(1-2):25-29, 2006.4 DOI: 10.1016/j.neulet.2005.11.067
  12. Ohnishi T, Hashimoto R, Mori T, Nemoto K, Moriguchi Y, Iida H, Yamada M, Noguchi H, Nakabayashi T, Hori H, Ohmori M, Tsukue R, Anami K, Hirabayashi N, Harada S, Arima K, Saitoh O, Kunugi H. The association between the Val158Met polymorphism of the Catechol-O-methyl transferase gene and morphological abnormalities of the brain in chronic schizophrenia. Brain, 129:399-410, 2006.2 DOI: 10.1093/brain/awh702
  13. Masui T, *Hashimoto R, Kusumi I, Suzuki K, Tanaka T, Nakagawa S, Kunugi H, Koyama T. A possible association between -116C/G single nucleotide polymorphism of XBP1 gene and lithium prophylaxis in bipolar disorder. Int J Neuropsychopharmacol, 9(1):83-88, 2006.2 DOI: 10.1017/S1461145705005523

2005年以前

  1. Kusumi I, Masui T, Kakiuchi C, Suzuki K, Akimoto T, Hashimoto R, Kunugi H, Kato T, Koyama T. Relationship between XBP1 genotype and personality traits assessed by TCI and NEO-FFI. Neurosci Lett, 391(1-2):7-10, 2005.12 DOI: 10.1016/j.neulet.2005.08.023
  2. Arinami T, Ohtsuki T, Ishiguro H, Ujike H, Tanaka Y, Morita Y, Mineta M, Takeichi M, Yamada S, Imamura A, Ohara K, Shibuya H, Ohara K, Suzuki Y, Muratake T, Kaneko N, Someya T, Inada T, Yoshikawa T, Toyota T, Yamada K, Kojima T, Takahashi S, Osamu O, Shinkai T, Nakamura M, Fukuzako H, Hashiguchi T, Niwa SI, Ueno T, Tachikawa H, Hori T, Asada T, Nanko S, Kunugi H, Hashimoto R, Ozaki N, Iwata N, Harano M, Arai H, Ohnuma T, Kusumi I, Koyama T, Yoneda H, Fukumaki Y, Shibata H, Kaneko S, Higuchi H, Yasui-Furukori N, Numachi Y, Itokawa M, Okazaki Y. Japanese Schizophrenia Sib-Pair Linkage Group. Genomewide high-density SNP linkage analysis of 236 Japanese families supports the existence of schizophrenia susceptibility Loci on chromosomes 1p, 14q, and 20p. Am J Hum Genet, 77(6):937-944, 2005.12 DOI: 10.1086/498122
  3. Tadokoro K, Hashimoto R, Tatsumi M, Kosuga A, Kamijima K, Kunugi H. The Gem interacting protein (GMIP) gene is associated with major depressive disorder. Neurogenetics, 6(3):127-133, 2005.9 DOI: 10.1007/s10048-005-0003-3
  4. *Hashimoto R, Okada T, Kato T, Kosuga A, Tatsumi M, Kamijima K, Kunugi H. The breakpoint cluster region (BCR) gene on chromosome 22q11 is associated with bipolar disorder. Biol Psychiatry, 57(10):1097-1102, 2005.5 DOI: 10.1016/j.biopsych.2005.02.019
  5. Miki R, Hattori K, Taguchi Y, Tada M, Isosaka T, Hidaka Y, Hirabayashi T, Hashimoto R, Fukuzako H, Yagi T. Identification and characterization of coding single-nucleotide polymorphisms within human protocadherin-alpha and beta gene clusters. Gene, 349:1-14, 2005.4 DOI: 10.1016/j.gene.2004.11.044
  6. *Hashimoto R, Yoshida M, Ozaki N, Yamanouchi Y, Iwata N, Suzuki T, Kitajima T, Tatsumi M, Kamijima K, Kunugi H. A missense polymorphism (H204R) of a Rho GTPase-activating protein, the chimerin 2 gene, is associated with schizophrenia in men. Schizophr Res, 73(2-3):383-385, 2005.3 DOI: 10.1016/j.schres.2004.01.017
  7. *Hashimoto R, Suzuki T, Iwata N, Yamanouchi Y, Kitajima T, Kosuga A, Tatsumi M, Ozaki N, Kamijima K, Kunugi H. Association study of the frizzled-3 (FZD3) gene with schizophrenia and mood disorders. J Neural Transm, 112(2):303-307, 2005.3 DOI: 10.1007/s00702-004-0264-2
  8. Numakawa T, Yagasaki Y, Ishimoto T, Okada T, Suzuki T, Iwata N, Ozaki N, Taguchi T, Tatsumi M, Kamijima K, Straub RE, Weinberger DR, Kunugi H, *Hashimoto R. Evidence of novel neuronal functions of dysbindin, a susceptibility gene for schizophrenia. Hum Mol Genet, 13(21):2699-2708, 2004.11 DOI: 10.1093/hmg/ddh280
  9. Kusumi I, Masui T, Kakiuchi C, Suzuki K, Akimoto T, Hashimoto R, Kunugi H, Kato T, Koyama T. Lack of association between XBP1 genotype and calcium signaling in the platelets of healthy subjects. Neurosci Lett. 369(1):1-3, 2004.10 DOI: 10.1016/j.neulet.2004.07.003
  10. Numakawa T, Ishimoto T, Suzuki S, Numakawa Y, Adachi N, Matsumoto T, Yokomaku D, Koshimizu H, Fujimori KE, *Hashimoto R, Taguchi T, Kunugi H. Neuronal roles of integrin-associated protein (IAP/ CD47) in developing cortical neurons. J Biol Chem, 279(41):43245-43253, 2004.10 DOI: 10.1074/jbc.M406733200
  11. Tadokoro K, Hashimoto R, Tatsumi M, Kamijima K, Kunugi H. Analysis of Enhancer activity of a dinucleotide repeat polymorphism in the neurotrophin-3 gene and its association with bipolar disorder. Neuropsychobiology, 50(3):206-210, 2004.9 DOI:10.1159/000079971
  12. Kunugi H, Iijima Y, Tatsumi M, Yoshida M, Hashimoto R, Kato T, Sakamoto K, Inada T, Suzuki T, Iwata N, Ozaki N, Yamada K, Yoshikawa T. No association between the Val66Met polymorphism of the brain-derived neurotrophic factor (BDNF) gene and bipolar disorder in Japanese: a multi-center study. Biol Psychiatry, 56(5):376-378, 2004.9 DOI: 10.1016/j.biopsych.2004.06.017
  13. Kunugi H, Hashimoto R, Yoshida M, Tatsumi M, Kamijima K. A missense polymorphism (S205L) of the low-affinity neurotrophin receptor p75NTR gene is associated with depressive disorder and attempted suicide. Am J Med Genet, 129B:44-46, 2004.8 DOI: 10.1002/ajmg.b.30062
  14. Weickert CS, Straub RE, McClintock BW, Matsumoto M, Hashimoto R, Hyde TM, Herman MM, Weinberger DR, Kleinman JE. Human dysbindin (DTNBP1) gene expression in normal brain and in schizophrenic prefrontal cortex and midbrain. Arch Gen Psychiatry, 61:544-555, 2004.6 DOI:10.1001/archpsyc.61.6.544
  15. Hashimoto R, Straub RE, Weickert CS, Hyde TM, Kleinman JE, Weinberger DR. Expression Analysis of Neuregulin-1 in the Dorsolateral Prefrontal Cortex in Schizophrenia. Mol Psychiatry, 9(3):299-307, 2004.3 DOI:10.1038/sj.mp.4001434
  16. *Hashimoto R, Yoshida M, Ozaki N, Yamanouchi Y, Iwata N, Suzuki T, Kitajima T, Tatsumi M, Kamijima K, Kunugi H. Association analysis of the -308G>A promoter polymorphism of the tumor necrosis factor alpha (TNF-α) gene in Japanese patients with schizophrenia. J Neural Transm, 111(2):217-221, 2004.2 DOI: 10.1007/s00702-003-0101-z
  17. Jeong MR, Hashimoto R, Senatorov VV, Fujimaki K, Ren M, Lee MS, Chuang D-M. Valproic acid, a mood stabilizer and anticonvulsant, protects rat cerebral cortical neurons from spontaneous cell death: a role of histone deacetylase inhibition. FEBS Lett, 542(1-3):74-78, 2003.5 DOI: 10.1016/S0014-5793(03)00350-8
  18. Matsumoto N, Nakamura Y, Kashiwagi Y, Hashimoto R, Kudo T, Tanaka T, Shinosaki K,Takeda M. Involvement of Rho-associated kinase in neurite sprouting and amyloid beta production of rat cortical neurons cultured in insulin-free medium. Psychogeriatrics, 3(1):21-28, 2003.5 DOI:10.1046/j.1479-8301.2003.00006.x
  19. Hashimoto R, Senatorov V, Kanai H, Leeds P, Chuang D-M. Lithium Stimulates Progenitor Proliferation in Cultured Brain Neurons. Neuroscience, 117(1):55-61, 2003.3 DOI: 10.1016/S0306-4522(02)00577-8
  20. Hashimoto R, Fujimaki K, Jeong MR, Christ L, Chuang D-M. Lithium-induced Inhibition of Src Tyrosine Kinase in Rat Cerebral Cortical Neurons: A Role in Neuroprotection against N-methyl-D-aspartate Receptor-mediated Excitotoxicity. FEBS Lett, 538(1-3):145-148, 2003.3 DOI: 10.1016/S0014-5793(03)00167-4
  21. Hashimoto R, Takei N, Shimazu K, Christ L, Lu B, Chuang D-M. Lithium Induces Brain-derived Neurotrophic Factor and Activates TrkB in Rodent Cortical Neurons: An Essential Step for Neuroprotection against Glutamate Excitotoxicity. Neuropharmacology, 43:1173-1179, 2002.12 DOI: 10.1016/S0028-3908(02)00217-4
  22. Chuang D-M, Chen RW, Chalecka-Franaszek E, Ren M, Hashimoto R, Senatorov V, Kanai H, Hough C, Hiroi T, Leeds P. Neuroprotective effects of lithium in cultured cells and animal models of diseases. Bipolar disorder, 4:129-136, 2002.4 DOI:10.1034/j.1399-5618.2002.01179.x
  23. Hashimoto R, Hough C, Nakazawa T, Yamamoto T, Chuang D-M, Lithium protection against glutamate excitotoxicity in rat cerebral cortical neurons: involvement of NMDA receptor inhibition possibly by decreasing NR2B tyrosine phosphorylation. J Neurochem, 80:589-597, 2002.2 DOI: 10.1046/j.0022-3042.2001.00728.x
  24. Hashimoto R, Nakamura Y, Imamura K, Nakadate K, Kashiwagi Y, Matsumoto N, Takeda M. Visual stimulation-induced phosphorylation of neurofilament-L in the visual cortex of dark-reared rats. Eur J Neuroscience, 14(8):1237-1245, 2001.10 DOI: 10.1046/j.0953-816x.2001.01747.x
  25. Nakamura Y, Hashimoto R, Amano M, Nagata K, Matsumoto N, Goto T, Fukusho E, Mori H, Kashiwagi Y, Kudo T, Inagaki M, Takeda M. Localized phosphorylation of vimentin by Rho-kinase in neuroblastoma N2a cells. GENES TO CELLS, 5:823-837, 2000.10 DOI: 10.1046/j.1365-2443.2000.00372.x
  26. Hashimoto R, Nakamura Y, Koma, S, Kashiwagi Y, Matsumoto N, Shiosaka S, Takeda M. Phosphorylation of Neurofilament-L during LTD. Neuroreport, 11:2739-2742, 2000.8 DOI: 10.1097/00001756-200008210-00026
  27. Hashimoto R, Nakamura Y, Komai S, Kashiwagi Y, Tamura K, Goto T, Aimoto S, Kaibuchi K, Shiosaka S, Takeda M. Site-specific phosphorylation of neurofilament-L is mediated by calcium/calmodulin dependent protein kinase II in the apical dendrites during long-term potentiation. J Neurochem, 75:373-382, 2000.7 DOI: 10.1046/j.1471-4159.2000.0750373.x
  28. Kudo T, Mima T, Hashimoto R, Morihara T, Tanimukai H, Tujio I, Nakamura Y, Mori K, Takeda M. Tau protein is a potential biological marker for normal pressure hydrocephalus. Psychiatry Clin Neurosci, 54:199-202, 2000.4 DOI:10.1046/j.1440-1819.2000.00658.x
  29. Nakamura Y, Hashimoto R, Kashiwagi Y, Aimoto S, Fukusho E, Matsumoto N, Kudo T, Takeda M. Major phosphorylation site ( Ser-55 ) of neurofilament L by cyclic AMP dependent protein kinase A in rat primary neuronal culture. J Neurochem, 74:949-959, 2000.3 DOI: 10.1046/j.1471-4159.2000.0740949.x
  30. Kametani F, Nakamura Y, Tanaka K, Hashimoto R, Takeda M. Semiquantitative analysis of amyloid beta peptides using a combination of immunoprecipitation and matrix-assisted laser desorption ionization/time-of-flight mass spectrometry. Anal Biochem, 275:262-265, 1999.11 DOI:10.1006/abio.1999.4330
  31. Hashimoto R, Nakamura Y, Tujio I, Tanimukai H, Kudo T, Takeda M. Quantitative analysis of neurofilament proteins in Alzheimer brain by enzyme linked immunosorbent assay system. Psychiatry Clin Neurosci, 53:587-591, 1999.10 DOI:10.1046/j.1440-1819.1999.00610.x
  32. Hashimoto R, Nakamura Y, Kosako H, Amano M, Kaibuchi K, Inagaki M, Takeda M. Distribution of Rho-kinase in the bovine brain. Biochem Biophys Res Commun, 263(2):575-579, 1999.9 DOI:10.1006/bbrc.1999.1409
  33. Nakamura Y, Hashimoto R, Kashiwagi Y, Wada Y, Sakoda S, Miyamae Y, Kudo T, Takeda M. Casein kinase II is responsible for phosphorylation of NF-L at Ser-473. FEBS Lett, 455(1-2):83-86, 1999.7 DOI:10.1016/S0014-5793(99)00832-7
  34. Tanimukai H, Tsujio I, Hashimoto R, Kudo T, Kamino K, Shinozaki K, Takeda M. Presenilin-2 mutation and polymorphism In Japanese Alzheimer disease patients. Clinica Chimica Acta, 283:57-61, 1999.5 DOI:10.1016/S0009-8981(99)00033-9
  35. Kashiwagi Y, Nakamura Y, Miyamae Y, Hashimoto R, Takeda M. Pulse exposure of cultured neurons to aluminum-maltol affected axonal transport system. Neurosci Lett, 252(1): 5-8, 1998.8 DOI:10.1016/S0304-3940(98)00505-9
  36. Hashimoto R, Nakamura Y, Goto H, Wada Y, Sakoda S, Kaibuchi K, Inagaki M, Takeda M. Domain- and site-specific phosphorylation of bovine NF-L by Rho-associated kinase. Biochem Biophys Res Commun, 245:407-411, 1998.4 DOI:10.1006/bbrc.1998.8446
  37. Nakamura Y, Hashimoto R, Kashiwagi Y, Miyamae Y, Shinozaki K, Nishikawa T, Hattori H, Kudo T, Takeda M. Abnormal distribution of neurofilament L in neurons with Alzhimer's disease. Neurosci Lett, 225:201-204, 1997.4 DOI:/10.1016/S0304-3940(97)00223-1

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