精神保健研究所 精神疾患病態研究部。私たちは「脳とこころの科学」の先駆的研究活動を展開しています。

その他:認知機能/神経生理機能

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  • その他:認知機能/神経生理機能

豊富な脳表現型コンソーシアムの主に健常者のデータを用いて、ヒトにおける認知機能のメカニズムを、主に遺伝子との関連で検討しています。また、他の診療科と連携して、例えば肝機能障害と認知機能の低さの正の相関を、世界で初めて発見して、報告しています。精神科以外の診療科と連携して研究をしたい人や、興味のある遺伝子の認知機能への影響を検討したい人はご連絡ください。

  1. Kamada Y, Hashimoto R, Yamamori H, Yasuda Y, Takehara T, Fujita Y, Hashimoto K, Miyoshi E. Impact of plasma transaminase levels on the peripheral blood glutamate levels and memory functions in healthy subjects. BBA Clin, 5:101-107, 2016.3
  2. Nishizawa D, Ohi K, *Hashimoto R, Yamamori H, Yasuda Y, Fujimoto M, Umeda-Yano S, Takeda M, Ikeda K. Association between genetic polymorphism rs2952768, close to the METTL21A and CREB1 genes, and intellectual ability in healthy subjects. Journal of Addiction Research & Therapy, 5(2):1000178, 2014.6
  3. Yasuda Y, *Hashimoto R, Ohi K, Yamamori H, Fujimoto M, Umeda-Yano S, Fujino H, Horiguchi M, Takeda M, Ichinose H. A functional polymorphism of the GTP cyclohydrolase I gene predicts attention performance. Neurosci Lett, 566:46?49, 2014.3
  4. Toriumi K, Kondo M, Nagai T, Hashimoto R, Ohi K, Song Z, Tanaka J, Mouri A, Koseki T, Yamamori H, Furukawa-Hibi Y, Mamiya T, Fukushima T, Takeda M, Nitta A, Yamada K, Nabeshima T. Deletion of SHATI/NAT8L increases dopamine D1 receptor on the cell surface in the nucleus accumbens, accelerating methamphetamine dependence. Int J Neuropsychopharmacol, 17:443-453, 2014.1
  5. Takahashi H, Iwase M, Yasuda Y, Ohi Y, Fukumoto M, Iike N, Yamamori H, Nakahachi T, Ikezawa K, Azechi M, Canuet L, Ishii R, Kazui H, Hashimoto R, Takeda M. Relationship of Prepulse Inhibition to Temperament and Character in Healthy Japanese subjects. Neurosci Res, 72(2):187-193, 2012.2
  6. Kazui H, Yoshida T, Takaya M, Sugiyama H, Yamamoto D, Kito Y, Wada T, Nomura K, Yasuda Y, Yamamori H, Ohi K, Fukumoto M, Iike N, Iwase M, Morihara T, Tagami S, Shimosegawa E, Hatazawa J, Ikeda Y, Uchida E, Tanaka T, Kudo T, Hashimoto R, Takeda M. Different Characteristics of Cognitive Impairment in Elderly Schizophrenia and Alzheimer’s Disease in the Mild Cognitive Impairment Stage. Dement Geriatr Cogn Disord, 2011:1:20-30, 2011.1
  7. Hayashi N, Kazui H, Kamino K, Tokunaga H, Takaya M, Yokokoji M, Kimura R, Kito Y, Wada T, Nomura K, Sugiyama H, Yamamoto D, Yoshida T, Currais A, Soriano S, Hamasaki T, Yamamoto M, Yasuda Y, Hashimoto R, Tanimukai H, Tagami S, Okochi M, Tanaka T, Kudo T, Morihara T, Takeda M. KIBRA genetic polymorphism influences episodic memory in Alzheimer’s disease, but does not show association with disease in a Japanese cohort. Dement Geriatr Cogn Disord, 30(4):302-308, 2010.10
  8. Takahashi H, Iwase M, Canuet L, Yasuda Y, Ohi K, Fukumoto M, Iike N, Nakahachi T, Ikezawa K, Azechi M, Kurimoto R, Ishii R, Yoshida T, Kazui H, Hashimoto R, Takeda M. Relationship between prepulse inhibition of acoustic startle response and schizotypy in healthy Japanese subjects. Psychophysiology, 47(5):831-837, 2010.9
  9. *Hashimoto R, Noguchi H, Hori H, Nakabayashi T, Suzuki T, Iwata N, Ozaki N, Kosuga A, Tatsumi M, Kamijima K, Harada S, Takeda M, Saitoh O, Kunugi H. A genetic variation in the dysbindin gene (DTNBP1) is associated with memory performance in healthy controls. World J Biol Psychiatry, 11:431-438, 2010.3
  10. Midorikawa A, Hashimoto R, Noguchi H, Saitoh O, Kunugi H, Nakamura K. Impairment of motor dexterity in schizophrenia assessed by a novel finger-movement test. Psychiatry Res, 159:281-289, 2008.6
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