精神保健研究所 精神疾患病態研究部。私たちは「脳とこころの科学」の先駆的研究活動を展開しています。

双極性障害:ゲノム/生体バイオマーカー/死後脳など

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  • 双極性障害:ゲノム/生体バイオマーカー/死後脳など

双極性障害に関しては、リチウムの治療反応性の研究を中心に行ってきました。国際的なリチウム反応性のコンソーシアムであるConLiGenにも参加しており、研究提案を行えば、そのデータを使った解析を行うことができます。脳神経画像、認知機能、神経生理機能のデータの蓄積はまだ十分とは言えませんが、逆に自分のアイデアで研究を進めていきたい人には向いている研究領域です。

  1. Ohi K, Kikuchi M, Ikeda M, Yamamori H, Yasuda Y, Fujimoto M, Fujino H, Miura K, Fukunaga M, Nakaya A, Iwata N, *Hashimoto R. Polygenetic Components for Schizophrenia, Bipolar Disorder and Rheumatoid Arthritis Predict Risk of Schizophrenia. Schizophr Res, 175:226-229, 2016.8
  2. Hou L, (38名中略)Hashimoto R, (124名中40番目)(83名中略)Schulze T.G., Genetic variants associated with response to lithium treatment in bipolar disorder: a genome-wide association study. Lancet, 12;387(10023):1085-93, 2016.3
  3. Yamamori H, Ishima T, Yasuda Y, Fujimoto M, Kudo N, Ohi K, Hashimoto K, Takeda M, Hashimoto R. Assessment of a multi-assay biological diagnostic test for mood disorders in a Japanese population. Neurosci Lett, 612:167-171, 2015.12
  4. Umeda-Yano S, *Hashimoto R, Yamamori H, Wickertd CS, Yasuda Y, Ohi K, Fujimoto M, Ito A, Takeda M. Expression analysis of the genes identified in GWAS of the postmortem brain tissues from patients with schizophrenia. Neurosci Lett, 568:12-16, 2014.3
  5. Seo S, Takayama K, Uno K, Ohi K, Hashimoto R, Nishizawa D, Ikeda K, Miyamoto Y, Ozaki N, Nabeshima T, Nitta A. Functional analysis of deep intronic SNP rs13438494 in intron 24 of PCLO gene. PLoS One, 8(10): e76960, 2013.10
  6. Manchia M, Adli M, Akula N, Ardau R, Aubry J.M., Backlund L, Banzato C, Baune B, Bellivier F, Bengeser S, Biernacka J, Brichant-Petitjean C, Bui E, Calkin C, Cheng A, Chillotti C, Cichon S, Clark S, Czerski P, Dantas C, Zompo M, DePaulo J, Detera-Wadleigh S, Etain B, Falkai P, Frisen L, Frye M, Fullerton J, Gard S, Garnham J, Goes F, Grof P, Gruber O, Hashimoto R, Hauser J, Heilbronner U, Hobann R, Hou L, Jamain S, Kahn J, Kassem L, Kato T, Kelsoe J, Kittel-Schneider S, Kliwicki S, Kuo P, Kusumi I, Laje G, Lavebratt C, Leboyer M, Leckband S, Jaaramillo C, Maj M, Malafosse A, Martinsson L, Masui T, Mitchell P, Mondimore F, Monteleone P, Nallet A, Neuner M, Novak T, O’Donovan C, Osby U, Ozaki N, Perlis R, Pfennig A, Potash J, Reich-Erkelenz D, Reif A, Reininghaus E, Richardson S, Rouleau G, Rybakowski J, Schalling M, Schofield P, Schubert O, Schweizer B, Seemuller F, Grigoroiu-Serbanescu M, Severino G, Seymour L, Slaney C, Smoller J, Squassina A, Stamm T, Steele J, Stopkova P, Tighe S, Tortorella A, Turecki G, Wray N, Wright A, Zandi P, Zilles D, Bauer M, Rietschel M, McMahon F, Schulze T, Alda M. Assessment of Response to Lithium maintenance Treatment in Bipolar Disorder: A Consortium on Lithium Genetics (ConLiGen) Report. PLoS One, 8(6): e65636, 2013.6
  7. Schulze T, Alda M, Adli M, Akula N, Ardau R, Chillotti C, Cichon S, Czerski P, Zompo M, SDetera-Wadleigh S, Grof P, Gruber O, Hashimoto R, Hauser J, Hoban R, Iwata N, Kassem L, Kato T, Kittel-Schneider S, Kliwicki S, Kelsoe J, Kusumi I, Laje G, Leckband S, Manchia M, MacQueen G, Masui T, Ozaki N, Perlis R, Pfennig A, Piccardi P, Richardson S, Rouleau G, Reif A, Rybakowski J, Sasse J, Schumacher J, Severino G, Smoller J, Squassina A, Turecki G, Young T, Yoshikawa T, Bauer M, McMahon F. The International Consortium on Lithium Genetics (ConLiGen): An Initiative by the NIMH and IGSLI to Study the Genetic Basis of Response to Lithium Treatment. Neuropsychobiology, 62(1):72-78, 2010.5
  8. Masui T, *Hashimoto R, Kusumi I, Suzuki K, Tanaka T, Nakagawa S, Suzuki T, Iwata N, Ozaki N, Kato T, Takeda M, Kunugi H, Koyama T. A possible association between missense polymorphism of the Breakpoint Cluster Region gene and lithium prophylaxis in bipolar disorder. Prog Neuropsychopharmacol Biol Psychiatry, 32:204-208, 2008.1
  9. Okada T, Hashimoto R, Numakawa T, Iijima Y, Kosuga A, Tatsumi M, Kamijima K, Kato T, Kunugi H. A complex polymorphic region in the brain-derived neurotrophic factor (BDNF) gene confers susceptibility to bipolar disorder and affects transcriptional activity. Mol Psychiatry, 11:695-703, 2006.7
  10. Masui T, *Hashimoto R, Kusumi I, Suzuki K, Tanaka T, Nakagawa S, Kunugi H, Koyama T. A possible association between -116C/G single nucleotide polymorphism of XBP1 gene and lithium prophylaxis in bipolar disorder. Int J Neuropsychopharmacol, 9(1):83-88, 2006.2
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