精神保健研究所 精神疾患病態研究部。私たちは「脳とこころの科学」の先駆的研究活動を展開しています。

うつ病:ゲノム/生体バイオマーカー/脳神経画像/認知機能/神経生理機能

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  • うつ病:ゲノム/生体バイオマーカー/脳神経画像/認知機能/神経生理機能

うつ病については、ゲノムや生体バイオマーカーの研究を中心に行ってきました。脳神経画像、認知機能、神経生理機能のデータが蓄積しつつありますので、研究を行いたい人は、統合失調症で培ったノウハウを生かして、中心的に研究を進めていただくことができます。

  1. Ohi K, Kikuchi M, Ikeda M, Yamamori H, Yasuda Y, Fujimoto M, Fujino H, Miura K, Fukunaga M, Nakaya A, Iwata N, *Hashimoto R. Polygenetic Components for Schizophrenia, Bipolar Disorder and Rheumatoid Arthritis Predict Risk of Schizophrenia. Schizophr Res, 175:226-229, 2016.8
  2. Yamamori H, Ishima T, Yasuda Y, Fujimoto M, Kudo N, Ohi K, Hashimoto K, Takeda M, Hashimoto R. Assessment of a multi-assay biological diagnostic test for mood disorders in a Japanesepopulation. Neurosci Lett, 612:167-171, 2015.12
  3. Takebayashi M, Hashimoto R, Hisaoka K, Tsuchioka M, Kunugi H. Plasma levels of vascular endothelial growth factor (VEGF) and fibroblast growth factor 2 (FGF-2) in patients with major depressive disorders. J Neural Transm, 117(9):1119-1122, 2010.9
  4. *Hashimoto R, Hashimoto H, Shintani N, Ohi K, Hori H, Saitoh O, Kosuga A, Tatsumi M, Iwata N, Ozaki N, Kamijima K, Baba A, Takeda M, Kunugi H. Possible association between the pituitary adenylate cyclase-activating polypeptide (PACAP) gene and major depressive disorder. Neurosci Lett, 468(3):300-302, 2010.1
  5. Kubota K, Inoue K, Hashimoto R, Kumamoto N, Kosuga A, Tatsumi M, Kamijima K, Kunugi H, Iwata N, Ozaki N, Takeda M, Tohyama M. Tumor necrosis factor receptor-associated protein 1 regulates cell adhesion and synaptic morphology via modulation of N-cadherin expression. J Neurochem, 110(2):496-508, 2009.7
  6. *Hashimoto R, Numakawa T, Ohnishi T, Kumamaru E, Yagasaki Y, Ishimoto T, Mori T, Nemoto K, Adachi N, Izumi A, Chiba S, Noguchi H, Suzuki T, Iwata N, Ozaki N, Taguchi T, Kamiya A, Kosuga A, Tatsumi M, Kamijima K, Weinberger DR, Sawa A, Kunugi H. Impact of the DISC1 Ser704Cys polymorphism on risk for major depression, brain morphology, and ERK signaling. Hum Mol Genet, 15:3024-3033, 2006.10
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