精神保健研究所 精神疾患病態研究部。私たちは「脳とこころの科学」の先駆的研究活動を展開しています。

統合失調症：認知機能

統合失調症の認知機能について、現在の認知機能だけでなく、病前からの認知機能の低下である認知機能障害についての検討も行っています。今後は、社会機能との関連や脳神経画像や眼球運動などの中間表現型との関連についても、検討していきます。また、認知機能の遺伝的背景について、ゲノム解析の成果も多数出ており、特定の遺伝子に興味のある基礎研究者との共同研究も多数行っています。統合失調症の認知機能障害の簡便な測定法を開発しており、全国の精神科医療機関への普及活動も行っています。興味のある方は、ご連絡ください。

  1. Sumiyoshi C, Fujino H, Sumiyoshi T, Yasuda Y, Yamamori H, Ohi K, Fujimoto M, Takeda M, Hashimoto R. Usefulness of the Wechsler Intelligence Scale short form for assessing functional outcomes in patients with schizophrenia. Psychiatry Res, 245:371-378, 2016.11
  2. Prosselkov P, Hashimoto R, Polygalov D, Ohi K, Zhang Qi, McHugh T, Takeda M, Itohara S. Cognitive enophenotypes of modern and extinct hominins associated with NTNG gene paralogs. Biomedical Genetics and Genomics, 1(1): 5-13, 2016.4
  3. Fujino H, Sumiyoshi C, Sumiyoshi T, Ysuda Y, Yamamori H, Ohi K, Fujimoto M, *Hashimoto R, Takeda M, Imura O. Predicting employment status and subjective quality of life in patients with schizophrenia. Schizophrenia Research: Cognition, 3:20-25, 2016. 3
  4. Ohi K, *Hashimoto R, Ikeda M, Yamamori H, Yasuda Y, Fujimoto M, Umeda-Yano S, Fukunaga M, Fujino H, Watanabe Y, Iwase M, Kazui H, Iwata N, Weinberger DR, Takeda M. Glutamate Networks Implicate Cognitive Impairments in Schizophrenia: Genome-Wide Association Studies of 52 Cognitive Phenotypes. Schizophr Bull, 41(4):909-18, 2015.7
  5. Shirai Y, Fujita Y, Hashimoto R, Ohi K, Yamamori H, Yasuda Y, Ishima T, Suganuma H, Ushida Y, Takeda M, Hashimoto K. Dietary intake of sulforaphane-rich broccoli sprout extracts during juvenile and adolescence can prevent phencyclidine-induced cognitive deficits at adulthood. PLoS One, 24;10(6):e0127244, 2015.6
  6. Matsuno H, Ohi K, *Hashimoto R, Yamamori H, Yasuda Y, Fujimoto M, Yano-Umeda S, Saneyoshi T, Takeda M, Hayashi Y. A naturally occurring null variant of the NMDA type glutamate receptor NR3B subunit is a risk factor of schizophrenia. PLoS One, 13;10(3):e0116319, 2015.3
  7. Onaka Y, Shintani N, Nakazawa T, Haba R, Ago Y, Wang H, Kanoh T, Hayata-Takano A, Hirai H, Nagata K, Nakamura M, Hashimoto R, Matsuda T, Waschek J.A., Kasai A, Nagayasu K, Baba A, Hashimoto H. CRTH2, a prostaglandin D2 receptor, mediates depression-related behavior in mice. Behav Brain Res, 284:131-137, 2015.2
  8. Fujino H, Sumiyoshi C, Sumiyoshi T, Yasuda Y, Yamamori H, Ohi K, Fujimoto M, Umeda-Yano S, Higuchi A, Hibi Y, Matsuura Y, *Hashimoto R, Takeda M, Imura O. Performance on the Wechsler Adult Intelligence Scale-III in Japanese patients with schizophrenia. Psychiatry Clin Neurosci, 68(7):534-541, 2014.7
  9. Horiguchi M, Ohi K, *Hashimoto R, Hao Q, Yasuda Y, Yamamori H, Fujimoto M, Umeda-Yano S, Takeda M, Ichinose H. A functional polymorphism (C-824T) of the tyrosine hydroxylase gene affects intelligence quotient in schizophrenia. Psychiatry Clin Neurosci, 68(6):456-62, 2014.6
  10. Dickinson D, Straub RE, Trampush JW, Gao Y, Feng N, Xie B, Shin JH, Lim HK, Ursini G, Bigos KL, Kolachana B, Hashimoto R, Takeda M, Baum GL, Rujescu D, Callicott JH, Hyde TM, Berman KF, Kleinman JE, Weinberger DR. Differential Effects of Common Variants in SCN2A on General Cognitive Ability, brain physiology, and messenger RNA Expression in Schizophrenia Cases and Control Individuals. JAMA Psychiatry, 1;71(6):647-56, 2014.6
  11. Fukumoto M, *Hashimoto R, Ohi K, Yasuda Y, Yamamori H, Umeda-Yano S, Iwase M, Kazui H, Takeda M. Relation between remission status and attention in patients withn schizophrenia. Psychiatry Clin Neurosci, 68(3):234-41, 2014.3
  12. Ohi K, *Hashimoto R, Yasuda Y, Fukumoto M, Yamamori H, Umeda-Yano S, Fujimoto M, Iwase M, Kazui H, Takeda M. Influence of the NRGN gene on intellectual ability in schizophrenia. J Hum Genet, 58(10):700-5, 2013.10
  13. *Hashimoto R, Ikeda M, Ohi K, Yasuda Y, Yamamori H, Fukumoto M, Umeda-Yano S, Dickinson D, Aleksic B, Iwase M, Kazui H, Ozaki N, Weinberger DR, Iwata N, Takeda M. Genome-wide association study of cognitive decline in schizophrenia. Am J Psychiatry, 170(6):683-684, 2013.6
  14. Ohi K, *Hashimoto R, Yasuda Y, Fukumoto M, Nemoto K, Ohnishi T, Yamamori H, Takahashi H, Iike N, Kamino K, Yoshida T, Azechi M, Ikezawa K, Tanimukai H, Tagami S, Morihara T, Okochi M, Tanaka T, Kudo T, Iwase M, Kazui H, Takeda M. The AKT1 gene is associated with attention and brain morphology in schizophrenia. World J Biol Psychiatry, 14(2):100-13, 2013.3
  15. *Hashimoto R, Ohi K, Yasuda Y, Fukumoto M, Yamamori H, Kamino K, Morihara T, Iwase M, Kazui H, Takeda M. The KCNH2 gene is associated with neurocognition and the risk of schizophrenia. World J Biol Psychiatry. 14(2):114-20, 2013.3
  16. Ohi K, *Hashimoto R, Yasuda Y, Fukumoto M, Yamamori H, Iwase M, Kazui H, Takeda M. Personality traits and schizophrenia: evidence from a case-control study and meta-analysis. Psychiatry Res, 198(1):7-11, 2012.6
  17. Wallwork RS, Fortgang R, Hashimoto R, Weinberger DR, Dickinson D. Searching for a consensus five-factor model of the Positive and Negative Syndrome Scale for schizophrenia. Schizophr Res, 137(1-3):246-50, 2012.5
  18. Ohi K, *Hashimoto R, Nakazawa T, Okada T, Yasuda Y, Yamamori H, Fukumoto M, Umeda-Yano S, Iwase M, Kazui H, Yamamoto T, Kano M, Takeda M. The p250GAP Gene is Associated with Risk for Schizophrenia and Schizotypal Personality Traits. PLoS One, 7(4):e35696, 2012.4
  19. Yamamori H, *Hashimoto R, Ohi K, Yasuda Y, Fukumoto M, Kasahara E, Sekiyama A, Umeda-Yano S, Okada T, Iwase M, Kazui H, Ito A, Takeda M. A promoter variant in the Chitinase 3-Like 1 gene is associated with serum YKL-40 level and personality trait. Neurosci Lett, 513(3):204-208, 2012.2
  20. Yasuda Y, *Hashimoto R, Ohi K, Fukumoto M, Umeda-Yano S, Yamamori H, Okochi T, Iwase M, Kazui H, Iwata N, Takeda M. Impact on schizotypal personality trait of a genome-wide supported psychosis variant of the ZNF804A gene. Neurosci let, 495:216-220, 2011.5
  21. Kazui H, Yoshida T, Takaya M, Sugiyama H, Yamamoto D, Kito Y, Wada T, Nomura K, Yasuda Y, Yamamori H, Ohi K, Fukumoto M, Iike N, Iwase M, Morihara T, Tagami S, Shimosegawa E, Hatazawa J, Ikeda Y, Uchida E, Tanaka T, Kudo T, Hashimoto R, Takeda M. Different Characteristics of Cognitive Impairment in Elderly Schizophrenia and Alzheimer’s Disease in the Mild Cognitive Impairment Stage. Dement Geriatr Cogn Disord, 2011:1:20-30, 2011.1
  22. *Hashimoto R, Ohi K, Yasuda Y, Fukumoto M, Iwase M, Iike N, Azechi M, Ikezawa K, Takaya M, Takahashi H, Yamamori H, Okochi T, Tanimukai H, Tagami S, Morihara T, Okochi M, Tanaka T, Kudo T, Kazui H, Iwata N, Takeda M. The Impact of a Genome-Wide Supported Psychosis Variant in the ZNF804A Gene on Memory Function in Schizophrenia. Am J Med Genet B Neuropsychiatr Genet, 153B(8):1459-1464, 2010.12
  23. *Hashimoto R, Noguchi H, Hori H, Ohi K, Yasuda Y, Takeda M, Kunugi H. Association between the dysbindin gene (DTNBP1) and cognitive functions in Japanese subjects. Psychiatry Clin Neurosci, 63(4):550-556, 2009.8
  24. Hori H, Noguchi H, Hashimoto R, Nakabayashi T, Saitoh O, Murray RM, Okabe S, Kunugi H. Personality in schizophrenia assessed with the Temperament and Character Inventory (TCI). Psychiatry Res, 160(2):175-183, 2008.8
  25. Hori H, Noguchi H, Hashimoto R, Saitoh O, Okabe S, Kunugi H. IQ decline and memory impairment in Japanese patients with chronic schizophrenia. Psychiatry Res, 158:251-255, 2008.3
  26. *Hashimoto R, Hashimoto H, Shintani N, Chiba S, Hattori S, Okada T, Nakajima M, Tanaka K, Kawagishi N, Nemoto K, Mori T, Ohnishi T, Noguchi H, Hori H, Suzuki T, Iwata N, Ozaki N, Nakabayashi T, Saitoh O, Kosuga A, Tatsumi M, Kamijima K, Weinberger DR, Kunugi H, Baba A. Pituitary adenylate cyclase-activating polypeptide is associated with schizophrenia. Mol Psychiatry, 12:1026-1032, 2007.12
  27. *Hashimoto R, Noguchi H, Hori H, Ohi K, Yasuda Y, Takeda M, Kunugi H. A possible association between the Val158Met polymorphism of the catechol-O-methyl transferase gene and the personality trait of harm avoidance in Japanese healthy subjects. Neurosci lett, 428(1):17-20, 2007.11
  28. Midorikawa A, Hashimoto R, Noguchi H, Saitoh O, Kunugi H, Nakamura K. Impairment of motor dexterity in schizophrenia assessed by a novel finger-movement test. Psychiatry Res, 159:281-289, 2008.6
  29. Hori H, Noguchi H, Hashimoto R, Nakabayashi T, Omori M, Takahashi S, Tsukue R, Anami K, Hirabayashi N, Harada S, Saitoh O, Iwase M, Kajimoto O, Takeda M, Okabe S, Kunugi H. Antipsychotic medication and cognitive function in schizophrenia. Schizophr Res, 86:138-146, 2006.9
国立精神・神経医療研究センター　精神疾患病態研究部 橋本亮太
国立精神・神経医療研究センター　精神疾患病態研究部 橋本亮太
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