精神保健研究所 精神疾患病態研究部。私たちは「脳とこころの科学」の先駆的研究活動を展開しています。

統合失調症：ゲノム

統合失調症のゲノム解析に関しては、いわゆるケースコントロール研究だけでなく、統合失調症の中間表現型のゲノム解析も多数行っています。COCOROをはじめとする国内外の多数の共同研究機関から、サンプルの提供を受けて研究を行うとともに、多数の研究機関にサンプルを提供して共同研究を推進しています。ゲノムデータに付随する中間表現型情報は、日本一の質と量であり、興味のある方は、様々な解析を行うことができます。

  1. Kushima I, Aleksic B, Nakatochi M, Shimamura T, Shiino T, Yoshimi A, Kimura H, Takasaki Y, Wang C, Xing J, Ishizuka K, Oya-Ito T, Nakamura Y, Arioka Y, Maeda T, Yamamoto M, Yoshida M, Noma H, Hamada S, Morikawa M, Uno Y, Okada T, Iidaka T, Iritani S, Yamamoto T, Miyashita M, Kobori A, Arai M, Itokawa M, Cheng MC, Chuang YA, Chen CH, Suzuki M, Takahashi T, Hashimoto R, Yamamori H, Yasuda Y, Watanabe Y, Nunokawa A, Someya T, Ikeda M, Toyota T, Yoshikawa T, Numata S, Ohmori T, Kunimoto S, Mori D, Iwata N, Ozaki N. High-resolution copy number variation analysis of schizophrenia in Japan. Mol Psychiatry, (e-pub ahead of print)
  2. Saito T, Ikeda M, Mushiroda T, Ozeki T, Kondo K, Shimasaki A, Kawase K, Hashimoto S, Yamamori H, Yasuda Y, Fujimoto M, Ohi K, Takeda M, Kamatani Y, Numata S, Ohmori T, Ueno S, Makinodan M, Nishihata Y, Kubota M, Kimura T, Kanahara N, Hashimoto N, Fujita K, Nemoto K, Fukao T, Suwa T, Noda T, Yada Y, Takaki M, Kida N, Otsuru T, Nurakami M, Takahashi A, Kubo M, *Hashimoto R, Iwata N. Pharmacogenomic study of clozapine-induced agranulocytosis/granulocytopenia in a Japanese population. Biol Psychiatry, 80:636-642, 2016.10
  3. Ohi K, Kikuchi M, Ikeda M, Yamamori H, Yasuda Y, Fujimoto M, Fujino H, Miura K, Fukunaga M, Nakaya A, Iwata N, *Hashimoto R. Polygenetic Components for Schizophrenia, Bipolar Disorder and Rheumatoid Arthritis Predict Risk of Schizophrenia. Schizophr Res, 175:226-229, 2016.8
  4. Inoshita M, Numata S, Tajima A, Kinoshita M, Umehara H, Nakataki M, Ikeda M, Maruyama M, Yamamori H, Kanazawa T, Shimodera S, Hashimoto R, Imoto I, Yoneda H, Iwata N, Ohmori T. A significant causal association between C-reactive protein levels and schizophrenia. Sci Rep, 6:26105, 2016.5
  5. Prosselkov P, Hashimoto R, Polygalov D, Ohi K, Zhang Qi, McHugh T, Takeda M, Itohara S. Cognitive enophenotypes of modern and extinct hominins associated with NTNG gene paralogs. Biomedical Genetics and Genomics, 1(1): 5-13, 2016.4
  6. Higashiyama R, Ohnuma T, Takebayashi Y, Hanzawa R, Shibata N, Yamamori H, Yasuda Y, Kushima I, Aleksic B, Kondo K, Ikeda M, Hashimoto R, Iwata N, Ozaki N, Arai H. Association of copy number polymorphisms at the promoter and translated region of COMT with Japanese patients with schizophrenia. Am J Med Genet B Neuropsychiatr Genet, 171(3):447-457, 2016.4
  7. *Nakazawa T, *Hashimoto R, Sakoori K, Sugaya Y, Tanimura A, Hashimotodani Y, Ohi K, Yamamori H, Yasuda Y, Umeda-Yano S, Kiyama Y, Konno K, Inoue T, Yokoyama K, Inoue T, Numata S, Ohnuma T, Iwata N, Ozaki N, Hashimoto H, Watanabe M, Manabe T, Yamamoto T, Takeda M, *Kano M. Emerging Roles of ARHGAP33 in Intracellular Trafficking of TrkB and Pathophysiology of Neuropsychiatric Disorders. Nat Commun, 7:10594, 2016.2
  8. Ohi K, *Hashimoto R, Ikeda M, Yamamori H, Yasuda Y, Fujimoto M, Umeda-Yano S, Fukunaga M, Fujino H, Watanabe Y, Iwase M, Kazui H, Iwata N, Weinberger DR, Takeda M. Glutamate Networks Implicate Cognitive Impairments in Schizophrenia: Genome-Wide Association Studies of 52 Cognitive Phenotypes. Schizophr Bull, 41(4):909-18, 2015.7
  9. Shirai Y, Fujita Y, Hashimoto R, Ohi K, Yamamori H, Yasuda Y, Ishima T, Suganuma H, Ushida Y, Takeda M, Hashimoto K. Dietary intake of sulforaphane-rich broccoli sprout extracts during juvenile and adolescence can prevent phencyclidine-induced cognitive deficits at adulthood. PLoS One, 24;10(6):e0127244, 2015.6
  10. Ohi K, Ursini G, Li M, Shin J.H.,Ye T, Chen Q, Tao R, Kleinman JE., Hyde TM., Hashimoto R, Weinberger DR. DEGS2 polymorphism associated with cognition in schizophrenia is associated with gene expression in brain. Transl Psychiatry, 14;5:e550, 2015.4
  11. Matsuno H, Ohi K, *Hashimoto R, Yamamori H, Yasuda Y, Fujimoto M, Yano-Umeda S, Saneyoshi T, Takeda M, Hayashi Y. A naturally occurring null variant of the NMDA type glutamate receptor NR3B subunit is a risk factor of schizophrenia. PLoS One, 13;10(3):e0116319, 2015.3
  12. Onaka Y, Shintani N, Nakazawa T, Haba R, Ago Y, Wang H, Kanoh T, Hayata-Takano A, Hirai H, Nagata K, Nakamura M, Hashimoto R, Matsuda T, Waschek J.A., Kasai A, Nagayasu K, Baba A, Hashimoto H. CRTH2, a prostaglandin D2 receptor, mediates depression-related behavior in mice. Behav Brain Res, 284:131-137, 2015.2
  13. Ikeda M, Yoshimura R, Hashimoto R, Kondo K, Saito T, Shimasaki A, Ohi K, Tochigi M, Kawamura Y, Nishida N, Miyagawa T, Sasaki T, Tokunaga K, Kasai K, Takeda M, Nakamura J, Ozaki N, Iwata N. Genetic overlap between antipsychotic response and susceptibility to schizophrenia. J Clin Psychopharmacol, 35(1):85-8, 2015.2
  14. Li M, Ohi K, Chen C, He Q, Lu JW, Chen C. Luo XJ, Dong Q, Hashimoto R, Su B. Failure of replicating the association between hippocampal volume and 3 single-nucleotide polymorphisms identified from theEuropean genome-wide association study in Asian populations. Neurobiol Aging, 35(12):2883e.1-2, 2014.12
  15. *Hashimoto R, Ikeda M, Yamashita F, Ohi K, Yamamori H, Yasuda Y, Fujimoto M, Fukunaga M, Nemoto K, Takahashi T, Ochigi M, Onitsuka T, Yamasue H, Matsuo K, Iidaka T, Iwata N, Suzuki M, Takeda M, Kasai K, Ozaki N. Common variants at 1p36 are associated with superior frontal gyrus volume. Transl Psychiatry, 4:e472, 2014.10
  16. Nishi A, Numata S, Tajima A, Kinoshita M, Kikuchi K, Shimodera S, Tomotake M, Ohi K, Hashimoto R, Imoto I, Takeda M, Ohmori T. Meta-analyses of blood homocysteine levels for gender and genetic association studies of the MTHFR C677T polymorphism in schizophrenia. Schizophr Bull, 40(5):1154-63, 2014.9
  17. Ohi K, *Hashimoto R, Ikeda M, Yamashita F, Fukunaga M, Nemoto K, Ohnishi T, Yamamori H, Yasuda Y, Fujimoto M, Umeda-Yano S, Watanabe Y, Iwata N, Weinberger DR, Takeda M. Genetic risk variants of schizophrenia associated with left superior temporal gyrus volume. Cortex, 58C:23-26, 2014.6
  18. Horiguchi M, Ohi K, *Hashimoto R, Hao Q, Yasuda Y, Yamamori H, Fujimoto M, Umeda-Yano S, Takeda M, Ichinose H. A functional polymorphism (C-824T) of the tyrosine hydroxylase gene affects intelligence quotient in schizophrenia. Psychiatry Clin Neurosci, 68(6):456-62, 2014.6
  19. Dickinson D, Straub RE, Trampush JW, Gao Y, Feng N, Xie B, Shin JH, Lim HK, Ursini G, Bigos KL, Kolachana B, Hashimoto R, Takeda M, Baum GL, Rujescu D, Callicott JH, Hyde TM, Berman KF, Kleinman JE, Weinberger DR. Differential Effects of Common Variants in SCN2A on General Cognitive Ability, brain physiology, and messenger RNA Expression in Schizophrenia Cases and Control Individuals. JAMA Psychiatry, 1;71(6):647-56, 2014.6
  20. Watanabe Y, Iijima Y, Egawa J, Nunokawa A, Kaneko N, Arinami T, Ujike H, Inada T, Iwata N, Kunugi H, Itokawa M, Sasaki T, Ozaki N, Hashimoto R, Shibuya M, Igeta H, Someya T. Replication in a Japanese population that a MIR30E gene variation is associated with schizophrenia. Schizophr Res, 150(2-3):596-7, 2013.11
  21. Ohi K, *Hashimoto R, Yasuda Y, Fukumoto M, Yamamori H, Umeda-Yano S, Fujimoto M, Iwase M, Kazui H, Takeda M. Influence of the NRGN gene on intellectual ability in schizophrenia. J Hum Genet, 58(10):700-5, 2013.10
  22. Kanazawa T, Ikeda M, Glatt S.J, Tsutsumi A, Kikuyama H, Kawamura Y, Nishida N, Miyagawa T, Hashimoto R, Takeda M, Sasaki T, Tokunaga K, Koh J, Iwata N, Yoneda H. Genome-Wide Association Study of Atypical Psychosis. Am J Med Genet B Neuropsychiatr Genet, 162(7):679-86, 2013.10
  23. Ohi K, *Hashimoto R, Yamamori H, Yasuda Y, Fujimoto M, Umeda-Yano S, Fukunaga M, Watanabe Y, Iwase M, Kazui H, Takeda M. The impact of the genome-wide supported variant in the cyclin M2 gene on gray matter morphology in schizophrenia. Behav Brain Funct, 9(1):40, 2013.10
  24. Ikeda M, Okahisa Y, Aleksic B, Won M, Kondo N, Naruse N, Aoyama-Uehara K, Sora I, Iyo M, Hashimoto R, Kawamura Y, Ninishida N, Miiyagawa T, Takeda M, Sasaki T, Tokunaga K, Ozaki N, Ujike H, Iwata N. Evidence for shared genetic risk between methamphetamine-induced psychosis and schizophrenia. Neuropsychopharmacology, 38(10):1864-70, 2013.9
  25. Furukawa M, Tochigi M, Otowa T, Arinami T, Inada T, Ujike H, Watanabe Y, Iwata N, Itokawa M, Kunugi H, Hashimoto R, Ozaki N, Kakiuchi C, Kasai K, Sasaki T. An association analysis of the cardiomyopathy-associated 5(CMYA5) gene with schizophrenia in a Japanese population. Psychiatr Genet, 23(4):179-180, 2013.8
  26. *Hashimoto R, Ikeda M, Ohi K, Yasuda Y, Yamamori H, Fukumoto M, Umeda-Yano S, Dickinson D, Aleksic B, Iwase M, Kazui H, Ozaki N, Weinberger DR, Iwata N, Takeda M. Genome-wide association study of cognitive decline in schizophrenia. Am J Psychiatry, 170(6):683-684, 2013.6
  27. Aleksic B., Kushima I, Hashimoto R, Ohi K, Ikeda M, Yoshimi A, Nakamura Y, Ito Y, Okochi T, Fukuo Y, Yasuda Y, Fukumoto M, Yamamori H, Ujike H, Suzuki M, Inada T, Takeda M, Kaibuchi K, Iwata N, Ozaki N. Analysis of the VAV3 as candidate gene for schizophrenia: evidences from voxel based morphometry and mutation screening. Schizophr Bull, 39(3):720-8, 2013.5
  28. Ohi K, *Hashimoto R, Yasuda Y, Fukumoto M, Nemoto K, Ohnishi T, Yamamori H, Takahashi H, Iike N, Kamino K, Yoshida T, Azechi M, Ikezawa K, Tanimukai H, Tagami S, Morihara T, Okochi M, Tanaka T, Kudo T, Iwase M, Kazui H, Takeda M. The AKT1 gene is associated with attention and brain morphology in schizophrenia. World J Biol Psychiatry, 14(2):100-13, 2013.3
  29. *Hashimoto R, Ohi K, Yasuda Y, Fukumoto M, Yamamori H, Kamino K, Morihara T, Iwase M, Kazui H, Takeda M. The KCNH2 gene is associated with neurocognition and the risk of schizophrenia. World J Biol Psychiatry. 14(2):114-20, 2013.3
  30. Kinoshita M, Numata S, Tajima A, Ohi K, Hashimoto R, Shimodera S, Imoto I, Itakura M, Takeda M, Ohmori T. Meta-analysis of association studies between DISC1 missense variants and schizophrenia in Japanese population. Schizophr Res, 141(2-3):271-3, 2012.11
  31. Kitazawa M, Ohnuma T, Takebayashi Y, Shibata N, Baba H, Ohi K, Yasuda Y, Nakamura Y, Aleksic B, Yoshimi A, Okochi T, Ikeda M, Naitoh H, Hashimoto R, Iwata N, Ozaki N, Takeda M, Arai H. No Associations Found between the Genes Situated at 6p22.1, HIST1H2BJ, PRSS16 and PGBD1 in Japanese Patients Diagnosed With Schizophrenia. Am J Med Genet B: Neuropsychiatri Genet, 159B(4):456-64, 2012.6
  32. Ohi K, *Hashimoto R, Yasuda Y, Fukumoto M, Yamamori H, Umeda-Yano S, Okada T, Kamino K, Morihara T, Iwase M, Kazui H, Numata S, Ikeda M, Ohmura T, Iwata N, Ueno S, Ozaki N, Ohmori T, Arai H, Takeda M. Functional genetic variation at the NRGN gene and schizophrenia: evidence from a gene-based case-control study and gene expression analysis. Am J Med Genet B Neuropsychiatr Genet, 159B(4):405-13, 2012.6
  33. Watanabe Y, Egawa J, Iijima Y, Nunokawa A, Kaneko N, Shibuya M, Arinami T, Ujike H, Inada T, Iwata N, Tochigi M, Kunugi H, Itokawa Ma, Ozaki N, Hashimoto R, Someya T. A two-stage case-control association study between the tryptophan hydroxylase 2(TPH2) gene and schizophrenia in a Japanese population. Schizophr Res, 137:264-266, 2012.5
  34. Koide T, Banno M, Aleksic B, Yamashita S, Kikuchi T, Kohmura K, Adachi Y, Kawano N, Kushima I, Nakamura Y, Okada T, Ikeda M, Ohi K, Yasuda Y, Hashimoto R, Inada T, Ujiike H, Iidaka T, Suzuki M, Takeda M, Iwata N, Ozaki N. Common Variants in MAGI2 Gene Are Associated with Increased Risk for Cognitive Impairment in Schizophrenic Patients. PLoS One, 7(5):e36836, 2012.5
  35. Kushima I, Nakamura Y, Aleksic B, Ikeda M, Ito Y, Shiino T, Okochi T, Fukuo Y, Ujike H, Suzuki M, Inada T, Hashimoto R, Takeda M, Kaibuchi K, Iwata N, Ozaki N. Resequencing and Association Analysis of the KALRN and EPHB1 Genes And Their Contribution to Schizophrenia Susceptibility. Schizophr Bull, 38(3):552-560, 2012.5
  36. Ohi K, *Hashimoto R, Nakazawa T, Okada T, Yasuda Y, Yamamori H, Fukumoto M, Umeda-Yano S, Iwase M, Kazui H, Yamamoto T, Kano M, Takeda M. The p250GAP Gene is Associated with Risk for Schizophrenia and Schizotypal Personality Traits. PLoS One, 7(4):e35696, 2012.4
  37. Yamamori H, *Hashimoto R, Ohi K, Yasuda Y, Fukumoto M, Kasahara E, Sekiyama A, Umeda-Yano S, Okada T, Iwase M, Kazui H, Ito A, Takeda M. A promoter variant in the Chitinase 3-Like 1 gene is associated with serum YKL-40 level and personality trait. Neurosci Lett, 513(3):204-208, 2012.2
  38. Ohi K, *Hashimoto R, Yasuda Y, Nemoto K, Ohnishi T, Fukumoto M, Yamamori H, Umeda-Yano S. Okada T, Iwase M, Kazui H, Takeda M. Impact of the Genome Wide Supported NRGN Gene on Anterior Cingulate Morphology in Schizophrenia. PLoS One, 7(1):e29780, 2012.1
  39. Ota M, Fujii T, Nemoto K, Tatsumi M, Moriguchi Y, Hashimoto R, Sato N, Iwata N, Kunugi H. A polymorphism of the ABCA1 gene confers susceptibility to schizophrenia and related brain changes. Prog Neuropsychopharmacol Biol Psychiatry, 35(8):1877-1883, 2011.12
  40. *Hashimoto R, Ohi K, Yasuda Y, Fukumoto M, Yamamori H, Takahashi H, Iwase M, Okochi T, Kazui H, Saitoh O, Tatsumi M, Iwata N, Ozaki N, Kamijima K, Kunugi H, Takeda M. Variants of the RELA gene are associated with schizophrenia and their startle responses. Neuropsychopharmacology, 36(9):1921-1931, 2011.8
  41. *Hashimoto R, Ohi K, Yasuda Y, Fukumoto M, Yamamori H, Kamino K, Morihara T, Iwase M, Kazui H, Numata S, Ikeda M, Ueno S, Ohmori T, Iwata N, Ozaki N, Takeda M. No association between the PCM1 gene and schizophrenia: a multi-center case-control study and a meta-analysis. Schizophr Res, 129:80-84, 2011.6
  42. Yasuda Y, *Hashimoto R, Ohi K, Fukumoto M, Umeda-Yano S, Yamamori H, Okochi T, Iwase M, Kazui H, Iwata N, Takeda M. Impact on schizotypal personality trait of a genome-wide supported psychosis variant of the ZNF804A gene. Neurosci let, 495:216-220, 2011.5
  43. Ohi K, *Hashimoto R, Yasuda Y, Fukumoto M, Yamamori H, Umeda-Yano S, Kamino K, Ikezawa K, Azechi M, Iwase M, Kazui H, Kasai K, Takeda M. The SIGMAR1 gene is associated with a risk of schizophrenia and activation of the prefrontal cortex. Prog Neuropsychopharmacol Biol Psychiatry, 35:1309-1315, 2011.4
  44. Ikeda M, Aleksic B, Kinoshita Y, Okochi T, Kawashima K, Kushima I, Ito Y, Nakamura Y, Kishi T, Okumura T, Fukuo Y, Williams HJ, Hamshere ML, Ivanov D, Inada T, Suzuki M, Hashimoto R, Ujike H, Takeda M, Craddock N, Kaibuchi K, Owen MJ, Ozaki N, O’Donovan MC, Iwata N. Genome-Wide Association Study of Schizophrenia in a Japanese Population. Biol Psychiatry, 69(5):472-478, 2011.3.
  45. *Hashimoto R, Ohi K, Yasuda Y, Fukumoto M, Iwase M, Iike N, Azechi M, Ikezawa K, Takaya M, Takahashi H, Yamamori H, Okochi T, Tanimukai H, Tagami S, Morihara T, Okochi M, Tanaka T, Kudo T, Kazui H, Iwata N, Takeda M. The Impact of a Genome-Wide Supported Psychosis Variant in the ZNF804A Gene on Memory Function in Schizophrenia. Am J Med Genet B Neuropsychiatr Genet, 153B(8):1459-1464, 2010.12
  46. Numata S, Nakataki M, Iga J, Tanahashi T, Nakadoi Y, Ohi K, Hashimoto R, Takeda M, Itakura M, Ueno S, Ohmori T. Association study between the pericentrin (PCNT) gene and schizophrenia. Neuromolecular Med, 12(3):243-247, 2010.9
  47. Koide T, Aleksic B, Ito Y, Usui H, Yoshimi A, Inada T, Suzuki M, Hashimoto R, Takeda M, Iwata N, Ozaki N. A two-stage case-control association study of the dihydropyrimidinase-like 2 gene (DPYSL2) with schizophrenia in Japanese subjects. J Hum Genet, 55(7):469-472, 2010.7
  48. Amagane H, Watanabe Y, Kaneko N, Nunokawa A, Muratake T, Ishiguro H, Arinami T, Ujike H, Inada T, Iwata N, Kunugi H, Sasaki T, Hashimoto R, Itokawa M, Ozaki N, Someya T. Failure to find an association between myosin heavy chain 9, non-muscle (MYH9) and schizophrenia: a three-stage case-control association study. Schizophr Res, 118(1-3):106-112, 2010.5
  49. Ohnuma T, Shibata N, Baba H, Ohi K, Yasuda Y, Nakamura Y, Okochi T, Naitoh H, Hashimoto R, Iwata N, Ozaki N, Takeda M, Arai H. No association between DAO and schizophrenia in a Japanese patient population: A multicenter replication study. Schizophr Res, 118(1-3):300-302, 2010.5
  50. Aleksic B, Kushima I, Ito Y, Nakamura Y, Ujike H, Suzuki M, Inada T, Hashimoto R, Takeda M, Iwata N, Ozaki N. Genetic association study of KREMEN1 and DKK1 and schizophrenia in a Japanese population. Schizophr Res, 118(1-3):113-117, 2010.5
  51. Ikeda M, Tomita Y, Mouri A, Koga M, Okochi T, Yoshimura R, Yamanouchi Y, Kinoshita Y, Hashimoto R, Williams H, Takeda M, Nakamura J, Nabeshima T, Owen M, O’Donovan M, Honda H, Arinami T, Ozaki N, Iwata N. Identification of novel candidate genes for treatment response to risperidone and susceptibility for schizophrenia: integrated analysis among pharmacogenomics, mouse expression and genetic case-control association approaches. Biol Psychiatry, 67(3):263-269, 2010.2
  52. Ohi K, *Hashimoto R, Yasuda Y, Yoshida T, Takahashi H, Iike N, Iwase M, Kamino K, Ishii R, Kazui H, Fukumoto M, Takamura H, Yamamori H, Azechi M, Ikezawa K, Tanimukai H, Tagami S, Morihara T, Okochi M, Yamada K, Numata S, Ikeda M, Tanaka T, Kudo T, Ueno S, Yoshikawa T, Ohmori T, Iwata N, Ozaki N, Takeda M. The Chitinase 3-Like 1 gene and schizophrenia: evidence from a multi-center case-control study and meta-analysis. Schizophr Res, 116:126-132, 2010.2
  53. Nunokawa A, Watanabe Y, Kaneko N, Sugai T, Yazaki S, Arinami T, Ujike H, Inada T, Iwata N, Kunugi H, Sasaki T, Itokawa M, Ozaki N, Hashimoto R, Someya T. The dopamine D3 receptor (DRD3) gene and risk of schizophrenia: case-control studies and an updated meta-analysis. Schizophr Res, 116(1):61-67, 2010.1
  54. *Hashimoto R, Ohi K, Okada T, Yasuda Y, Yamamori H, Hori H, Hikita T, Taya S, Saitoh O, Kosuga A, Tatsumi M, Kamijima K, Kaibuchi K, Takeda M, Kunugi H. Association analysis between schizophrenia and the AP-3 complex genes. Neurosci Res, 65(1):113-115, 2009.9
  55. Ohi K, *Hashimoto R, Yasuda Y, Yamamori H, Hori H, Saitoh O, Tatsumi M, Takeda M, Iwata N, Ozaki N, Kamijima K, Kunugi H. No association between the Bcl2-interacting killer (BIK) gene and schizophrenia. Neurosci Lett, 463(1):60-63, 2009.9
  56. *Hashimoto R, Noguchi H, Hori H, Ohi K, Yasuda Y, Takeda M, Kunugi H. Association between the dysbindin gene (DTNBP1) and cognitive functions in Japanese subjects. Psychiatry Clin Neurosci, 63(4):550-556, 2009.8
  57. Ohi K, *Hashimoto R, Yasuda Y, Yoshida T, Takahashi H, Iike N, Fukumoto M, Takamura H, Iwase M, Kamino K, Ishii R, Kazui H, Sekiyama R, Kitamura Y, Azechi M, Ikezawa K, Kurimoto R, Kamagata E, Tanimukai H, Tagami S, Morihara T, Ogasawara M, Okochi M, Tokunaga H, Numata S, Ikeda M, Ohnuma T, Ueno S, Fukunaga T, Tanaka T, Kudo T, Arai H, Ohmori T, Iwata N, Ozaki N, Takeda M. Association study of the G72 gene with schizophrenia in a Japanese population: a multicenter study. Schizophr Res, 109(1-3), 80-85, 2009.4
  58. Ohi K, *Hashimoto R, Yasuda Y, Kiribayashi M, Iike N, Yoshida T, Azechi M, Ikezawa K, Takahashi H, Morihara T, Ishi R, Tagami S, Iwase M, Okochi M, Kamino K, Kazui H, Tanaka T, Kudo T, Takeda M. TATA Box-Binding Protein gene is associated with risk for schizophrenia, age at onset and prefrontal function. Genes Brain Behav, 8(4):473-480, 2009.1
  59. Kawashima K, Kishi T, Ikeda M, Kitajima T, Yamanouchi Y, Kinoshita Y, Takahashi N, Saito S, Ohi K, Yasuda Y, Hashimoto R, Takeda M, Inada T, Ozaki N, Iwata N. No Association between Tagging SNPs of SNARE Complex Genes (STX1A, VAMP2 and SNAP25) and Schizophrenia in a Japanese Population. Am J Med Genet, 147B(7):1327-1331, 2008.10
  60. Mizuguchi T, Hashimoto R, Itokawa M, Sano A, Shimokawa O, Yoshimura Y, Harada N, Miyake N, Nishimura A, Saitsu H, Sosonkina N, Niikawa N, Kunugi H, Matsumoto N. Microarray comparative genomic hybridization analysis of 59 patients with schizophrenia. J Hum Genet, 53(10):914-919, 2008.8
  61. Numata S, Shu-ichi Ueno S, Iga J, Yamauchi K, Hongwei S, Hashimoto R, Takeda M, Kunugi H, Itakura M, Ohmori T. TGFBR2 Gene expression and genetic association with schizophrenia. J Psychiatr Res, 42(6):425-432, 2008.5
  62. Ikeda M, Takahashi N, Saito S, Aleksic B, Watanabe Y, Nunokawa A, Yamanouchi Y, Kitajima T, Kinoshita Y, Kishi T, Kawashima K, Hashimoto R, Ujike H, Inada T, Someya T, Takeda M, Ozaki N, Iwata N. Failure to replicate the association between NRG1 and schizophrenia using Japanese large-sample. Schizophr Res, 101:1-8, 2008.4
  63. Numata S, Ueno S, Iga J, Nakataki M, Tanahashi T, Itakura M, Sano A, Ohi K, Hashimoto R, Takeda M, Ohmori T. No association between the NDE1 gene and schizophrenia in the Japanese Population. Schizophr Res, 99(1-3):367-369, 2008.2
  64. *Hashimoto R, Hashimoto H, Shintani N, Chiba S, Hattori S, Okada T, Nakajima M, Tanaka K, Kawagishi N, Nemoto K, Mori T, Ohnishi T, Noguchi H, Hori H, Suzuki T, Iwata N, Ozaki N, Nakabayashi T, Saitoh O, Kosuga A, Tatsumi M, Kamijima K, Weinberger DR, Kunugi H, Baba A. Pituitary adenylate cyclase-activating polypeptide is associated with schizophrenia. Mol Psychiatry, 12:1026-1032, 2007.12
  65. *Hashimoto R, Noguchi H, Hori H, Ohi K, Yasuda Y, Takeda M, Kunugi H. A possible association between the Val158Met polymorphism of the catechol-O-methyl transferase gene and the personality trait of harm avoidance in Japanese healthy subjects. Neurosci lett, 428(1):17-20, 2007.11
  66. Kunugi H, Hashimoto R, Okada T, Hori H, Nakabayashi T, Baba A, Kudo K, Ohmori M, Takahashi S, Tsukue R, Anami K, Hirabayashi N, Kosuga A, Tatsumi M, Kamijima K, Asada T, Harada S, Arima K, Saitoh O. Possible association between nonsynonymous polymorphisms of the anaplastic lymphoma kinase (ALK) gene and schizophrenia in a Japanese population. J Neural Transm, 113:1569-1573, 2006.10
  67. Nemoto K, Ohnishi T, Mori T, Moriguchi Y, Hashimoto R, Asada T, Kunugi H. The Val66Met polymorphism of the BDNF gene affects age-related brain morphology. Neurosci Lett, 397(1-2):25-29, 2006.4
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